First Pediatric Case of Clinically-Diagnosed Penicillin G-Induced Hemorrhagic Cystitis
Hemorrhagic cystitis is a diffuse inflammatory disease of the urinary bladder associated with macrohematuria. Several cases of hemorrhagic cystitis caused by penicillin G have been reported in adults but not children. Here we describe the first pediatric case of clinically-diagnosed penicillin G-ind...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2022-12, Vol.14 (12), p.e32246 |
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| creator | Hayashi, Ryo Urushihara, Yasuko Ishido, Hirotaka Iwamoto, Yoichi Korematsu, Seigo Masutani, Satoshi |
| description | Hemorrhagic cystitis is a diffuse inflammatory disease of the urinary bladder associated with macrohematuria. Several cases of hemorrhagic cystitis caused by penicillin G have been reported in adults but not children. Here we describe the first pediatric case of clinically-diagnosed penicillin G-induced hemorrhagic cystitis. The patient was a 9-year-old boy with a ventricular septal defect, chromosomal abnormalities, and infective endocarditis caused by
. After approximately four weeks of penicillin G administration, he had a culture-negative major hemorrhage with a clot. The hematuria resolved one week after penicillin G discontinuation, and a drug lymphocyte stimulation test for penicillin G was positive. In conclusion, penicillin G can also induce hemorrhagic cystitis in children. When large doses of penicillin G are used for long periods in adults or children, the patient should be monitored for hemorrhagic cystitis. |
| doi_str_mv | 10.7759/cureus.32246 |
| format | Article |
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. After approximately four weeks of penicillin G administration, he had a culture-negative major hemorrhage with a clot. The hematuria resolved one week after penicillin G discontinuation, and a drug lymphocyte stimulation test for penicillin G was positive. In conclusion, penicillin G can also induce hemorrhagic cystitis in children. When large doses of penicillin G are used for long periods in adults or children, the patient should be monitored for hemorrhagic cystitis.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.32246</identifier><identifier>PMID: 36620836</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Adults ; Antibiotics ; Bacterial infections ; Bladder ; Blood ; Case reports ; Disease prevention ; Endocarditis ; Hematuria ; Immunology ; Infections ; Laboratories ; Medical diagnosis ; Patients ; Pediatrics ; Penicillin ; Proteins ; Radiation ; Viral infections</subject><ispartof>Curēus (Palo Alto, CA), 2022-12, Vol.14 (12), p.e32246</ispartof><rights>Copyright © 2022, Hayashi et al.</rights><rights>Copyright © 2022, Hayashi et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c277t-2c799cc6f812432b828c9a8ed2a588b7506e8bea61d97f9e11736393e98f67043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36620836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hayashi, Ryo</creatorcontrib><creatorcontrib>Urushihara, Yasuko</creatorcontrib><creatorcontrib>Ishido, Hirotaka</creatorcontrib><creatorcontrib>Iwamoto, Yoichi</creatorcontrib><creatorcontrib>Korematsu, Seigo</creatorcontrib><creatorcontrib>Masutani, Satoshi</creatorcontrib><title>First Pediatric Case of Clinically-Diagnosed Penicillin G-Induced Hemorrhagic Cystitis</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Hemorrhagic cystitis is a diffuse inflammatory disease of the urinary bladder associated with macrohematuria. Several cases of hemorrhagic cystitis caused by penicillin G have been reported in adults but not children. Here we describe the first pediatric case of clinically-diagnosed penicillin G-induced hemorrhagic cystitis. The patient was a 9-year-old boy with a ventricular septal defect, chromosomal abnormalities, and infective endocarditis caused by
. After approximately four weeks of penicillin G administration, he had a culture-negative major hemorrhage with a clot. The hematuria resolved one week after penicillin G discontinuation, and a drug lymphocyte stimulation test for penicillin G was positive. In conclusion, penicillin G can also induce hemorrhagic cystitis in children. When large doses of penicillin G are used for long periods in adults or children, the patient should be monitored for hemorrhagic cystitis.</description><subject>Adults</subject><subject>Antibiotics</subject><subject>Bacterial infections</subject><subject>Bladder</subject><subject>Blood</subject><subject>Case reports</subject><subject>Disease prevention</subject><subject>Endocarditis</subject><subject>Hematuria</subject><subject>Immunology</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Medical diagnosis</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Penicillin</subject><subject>Proteins</subject><subject>Radiation</subject><subject>Viral infections</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpNkEtPwzAQhC0EolXpjTOKxJUUP1I_jijQh1QJDsDVcpxNcZUmxU4O_fd1aUGcdjX77Yw0CN0SPBFiqh5t76EPE0Zpxi_QkBIuU0lkdvlvH6BxCBuMMcGCYoGv0YBxTrFkfIg-Z86HLnmD0pnOO5vkJkDSVkleu8ZZU9f79NmZddMGKCMWNVfHUzJPl03Z2yguYNt6_2XWx-996Fznwg26qkwdYHyeI_Qxe3nPF-nqdb7Mn1appUJ0KbVCKWt5JQnNGC0klVYZCSU1UykLMcUcZAGGk1KJSgEhgnGmGChZcYEzNkL3J9-db797CJ3etL1vYqSOAUdTzkSkHk6U9W0IHiq9825r_F4TrI896lOP-qfHiN-dTftiC-Uf_NsaOwBBgm4G</recordid><startdate>20221206</startdate><enddate>20221206</enddate><creator>Hayashi, Ryo</creator><creator>Urushihara, Yasuko</creator><creator>Ishido, Hirotaka</creator><creator>Iwamoto, Yoichi</creator><creator>Korematsu, Seigo</creator><creator>Masutani, Satoshi</creator><general>Cureus Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20221206</creationdate><title>First Pediatric Case of Clinically-Diagnosed Penicillin G-Induced Hemorrhagic Cystitis</title><author>Hayashi, Ryo ; 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Several cases of hemorrhagic cystitis caused by penicillin G have been reported in adults but not children. Here we describe the first pediatric case of clinically-diagnosed penicillin G-induced hemorrhagic cystitis. The patient was a 9-year-old boy with a ventricular septal defect, chromosomal abnormalities, and infective endocarditis caused by
. After approximately four weeks of penicillin G administration, he had a culture-negative major hemorrhage with a clot. The hematuria resolved one week after penicillin G discontinuation, and a drug lymphocyte stimulation test for penicillin G was positive. In conclusion, penicillin G can also induce hemorrhagic cystitis in children. When large doses of penicillin G are used for long periods in adults or children, the patient should be monitored for hemorrhagic cystitis.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>36620836</pmid><doi>10.7759/cureus.32246</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adults Antibiotics Bacterial infections Bladder Blood Case reports Disease prevention Endocarditis Hematuria Immunology Infections Laboratories Medical diagnosis Patients Pediatrics Penicillin Proteins Radiation Viral infections |
| title | First Pediatric Case of Clinically-Diagnosed Penicillin G-Induced Hemorrhagic Cystitis |
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