Association of xenobiotic-metabolizing genes polymorphisms with cervical cancer risk in the Tunisian population
Background Host genetic characteristics and environmental factors interactions may play a crucial role in cervical carcinogenesis. We investigated the impact of functional genetic variants of four xenobiotic-metabolizing genes ( AhR , CYP1A1 , GSTM1 , and GSTT1 ) on cervical cancer development in Tu...
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| Veröffentlicht in: | Molecular biology reports 2023-02, Vol.50 (2), p.949-959 |
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| description | Background
Host genetic characteristics and environmental factors interactions may play a crucial role in cervical carcinogenesis. We investigated the impact of functional genetic variants of four xenobiotic-metabolizing genes (
AhR
,
CYP1A1
,
GSTM1
, and
GSTT1
) on cervical cancer development in Tunisian women.
Methods
The
AhR
gene polymorphism was analyzed using the tetra-primer ARMS-PCR, whereas the
CYP1A1
polymorphism genotypes were identified by PCR-RFLP. A multiplex ligation-dependent polymerase chain reaction approach was applied for the analysis of
GSTM1
and
GSTT1
polymorphisms.
Results
The homozygous A/A genotype of the
AhR
gene (rs2066853) and the heterozygous T/C genotype of the
CYP1A1
SNP (
CYP1A1-MspI
) appeared to be associated with an increased risk of cervical tumorigenesis (OR
a
= 2.81; OR
a
= 5.52, respectively). Furthermore, a significantly increased risk of cervical cancer was associated with the
GSTT1
null genotype (OR
a
= 2.65). However, the null
GSTM1
genotype showed any significant association with the risk of cervical cancer compared to the wild genotype (OR
a
= 1.18;
p
= 0.784). Considering the combined effect, we noted a significantly higher association with cancer risk for individuals with at least two high-risk genotypes of CYP1A1/GSTT1 (OR
a
= 4.2), individuals with at least two high-risk genotypes of CYP1A1/GSTT1/AhR (OR
a
= 11.3) and individuals with at least two high-risk genotypes of CYP1A1/GSTM1/GSTT1/AhR exploitation low-risk genotype as a reference.
Conclusion
This study indicated that the single-gene contribution and the combined effect of xenobiotic-metabolizing gene polymorphisms (
AhR
,
CYP1A1-MspI
,
GSTM1
, and
GSTT1
) may have a considerable association with increased cervical cancer risk. |
| doi_str_mv | 10.1007/s11033-022-07945-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2771188532</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2771188532</sourcerecordid><originalsourceid>FETCH-LOGICAL-c305t-81a41cb80ed9f555a25bb09784f3ce06761e44c292ef7df834a960eb96421c5a3</originalsourceid><addsrcrecordid>eNp9kEtP3DAQx62qCJbHF-CALPVsOn4nR4RKQULqBc6W43V2TRM7tZOW7aevYaG99TQjzf-h-SF0TuGSAujPhVLgnABjBHQrJFEf0IpKzYlodfMRrYADJaKR9Agdl_IEAIJqeYiOuOJaSa5WKF2Vklywc0gRpx4_-5i6kObgyOhn26Uh_A5xgzc--oKnNOzGlKdtKGPBv8K8xc7nn8HZATsb645zKN9xiHjeevywxFCCjdU3LcNrxyk66O1Q_NnbPEGPN18erm_J_bevd9dX98RxkDNpqBXUdQ34ddtLKS2TXQf1K9Fz50FpRb0QjrXM93rdN1zYVoHvWiUYddLyE_Rpnzvl9GPxZTZPacmxVhqmNaVNIzmrKrZXuZxKyb43Uw6jzTtDwbwwNnvGpjI2r4yNqqaLt-ilG_36r-UdahXwvaDUU9z4_K_7P7F_AMEyiTY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2771188532</pqid></control><display><type>article</type><title>Association of xenobiotic-metabolizing genes polymorphisms with cervical cancer risk in the Tunisian population</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Helaoui, Ahlem ; Sfar, Sana ; Boudhiba, Najet ; Dehghanian, Fariba ; Dehbashi, Moein ; Bouchahda, Haifa ; Hojati, Zohreh ; Kenani, Abderraouf</creator><creatorcontrib>Helaoui, Ahlem ; Sfar, Sana ; Boudhiba, Najet ; Dehghanian, Fariba ; Dehbashi, Moein ; Bouchahda, Haifa ; Hojati, Zohreh ; Kenani, Abderraouf</creatorcontrib><description>Background
Host genetic characteristics and environmental factors interactions may play a crucial role in cervical carcinogenesis. We investigated the impact of functional genetic variants of four xenobiotic-metabolizing genes (
AhR
,
CYP1A1
,
GSTM1
, and
GSTT1
) on cervical cancer development in Tunisian women.
Methods
The
AhR
gene polymorphism was analyzed using the tetra-primer ARMS-PCR, whereas the
CYP1A1
polymorphism genotypes were identified by PCR-RFLP. A multiplex ligation-dependent polymerase chain reaction approach was applied for the analysis of
GSTM1
and
GSTT1
polymorphisms.
Results
The homozygous A/A genotype of the
AhR
gene (rs2066853) and the heterozygous T/C genotype of the
CYP1A1
SNP (
CYP1A1-MspI
) appeared to be associated with an increased risk of cervical tumorigenesis (OR
a
= 2.81; OR
a
= 5.52, respectively). Furthermore, a significantly increased risk of cervical cancer was associated with the
GSTT1
null genotype (OR
a
= 2.65). However, the null
GSTM1
genotype showed any significant association with the risk of cervical cancer compared to the wild genotype (OR
a
= 1.18;
p
= 0.784). Considering the combined effect, we noted a significantly higher association with cancer risk for individuals with at least two high-risk genotypes of CYP1A1/GSTT1 (OR
a
= 4.2), individuals with at least two high-risk genotypes of CYP1A1/GSTT1/AhR (OR
a
= 11.3) and individuals with at least two high-risk genotypes of CYP1A1/GSTM1/GSTT1/AhR exploitation low-risk genotype as a reference.
Conclusion
This study indicated that the single-gene contribution and the combined effect of xenobiotic-metabolizing gene polymorphisms (
AhR
,
CYP1A1-MspI
,
GSTM1
, and
GSTT1
) may have a considerable association with increased cervical cancer risk.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-022-07945-6</identifier><identifier>PMID: 36376536</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>AhR gene ; Animal Anatomy ; Animal Biochemistry ; Biomedical and Life Sciences ; Carcinogenesis ; Case-Control Studies ; Cervical cancer ; Cytochrome P-450 CYP1A1 - genetics ; Cytochrome P450 ; Environmental factors ; Female ; Gene polymorphism ; Genes ; Genetic diversity ; Genetic Predisposition to Disease ; Genotype ; Genotype & phenotype ; Glutathione Transferase - genetics ; GSTM1 protein ; GSTT1 protein ; Histology ; Humans ; Life Sciences ; Morphology ; Original Article ; Polymerase chain reaction ; Polymorphism ; Polymorphism, Genetic ; Population genetics ; Restriction fragment length polymorphism ; Risk Factors ; Single-nucleotide polymorphism ; Tumorigenesis ; Uterine Cervical Neoplasms - genetics ; Xenobiotics</subject><ispartof>Molecular biology reports, 2023-02, Vol.50 (2), p.949-959</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer Nature B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-81a41cb80ed9f555a25bb09784f3ce06761e44c292ef7df834a960eb96421c5a3</citedby><cites>FETCH-LOGICAL-c305t-81a41cb80ed9f555a25bb09784f3ce06761e44c292ef7df834a960eb96421c5a3</cites><orcidid>0000-0002-1647-5495</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-022-07945-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-022-07945-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36376536$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Helaoui, Ahlem</creatorcontrib><creatorcontrib>Sfar, Sana</creatorcontrib><creatorcontrib>Boudhiba, Najet</creatorcontrib><creatorcontrib>Dehghanian, Fariba</creatorcontrib><creatorcontrib>Dehbashi, Moein</creatorcontrib><creatorcontrib>Bouchahda, Haifa</creatorcontrib><creatorcontrib>Hojati, Zohreh</creatorcontrib><creatorcontrib>Kenani, Abderraouf</creatorcontrib><title>Association of xenobiotic-metabolizing genes polymorphisms with cervical cancer risk in the Tunisian population</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>Background
Host genetic characteristics and environmental factors interactions may play a crucial role in cervical carcinogenesis. We investigated the impact of functional genetic variants of four xenobiotic-metabolizing genes (
AhR
,
CYP1A1
,
GSTM1
, and
GSTT1
) on cervical cancer development in Tunisian women.
Methods
The
AhR
gene polymorphism was analyzed using the tetra-primer ARMS-PCR, whereas the
CYP1A1
polymorphism genotypes were identified by PCR-RFLP. A multiplex ligation-dependent polymerase chain reaction approach was applied for the analysis of
GSTM1
and
GSTT1
polymorphisms.
Results
The homozygous A/A genotype of the
AhR
gene (rs2066853) and the heterozygous T/C genotype of the
CYP1A1
SNP (
CYP1A1-MspI
) appeared to be associated with an increased risk of cervical tumorigenesis (OR
a
= 2.81; OR
a
= 5.52, respectively). Furthermore, a significantly increased risk of cervical cancer was associated with the
GSTT1
null genotype (OR
a
= 2.65). However, the null
GSTM1
genotype showed any significant association with the risk of cervical cancer compared to the wild genotype (OR
a
= 1.18;
p
= 0.784). Considering the combined effect, we noted a significantly higher association with cancer risk for individuals with at least two high-risk genotypes of CYP1A1/GSTT1 (OR
a
= 4.2), individuals with at least two high-risk genotypes of CYP1A1/GSTT1/AhR (OR
a
= 11.3) and individuals with at least two high-risk genotypes of CYP1A1/GSTM1/GSTT1/AhR exploitation low-risk genotype as a reference.
Conclusion
This study indicated that the single-gene contribution and the combined effect of xenobiotic-metabolizing gene polymorphisms (
AhR
,
CYP1A1-MspI
,
GSTM1
, and
GSTT1
) may have a considerable association with increased cervical cancer risk.</description><subject>AhR gene</subject><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Carcinogenesis</subject><subject>Case-Control Studies</subject><subject>Cervical cancer</subject><subject>Cytochrome P-450 CYP1A1 - genetics</subject><subject>Cytochrome P450</subject><subject>Environmental factors</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genetic diversity</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Glutathione Transferase - genetics</subject><subject>GSTM1 protein</subject><subject>GSTT1 protein</subject><subject>Histology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Morphology</subject><subject>Original Article</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Population genetics</subject><subject>Restriction fragment length polymorphism</subject><subject>Risk Factors</subject><subject>Single-nucleotide polymorphism</subject><subject>Tumorigenesis</subject><subject>Uterine Cervical Neoplasms - genetics</subject><subject>Xenobiotics</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kEtP3DAQx62qCJbHF-CALPVsOn4nR4RKQULqBc6W43V2TRM7tZOW7aevYaG99TQjzf-h-SF0TuGSAujPhVLgnABjBHQrJFEf0IpKzYlodfMRrYADJaKR9Agdl_IEAIJqeYiOuOJaSa5WKF2Vklywc0gRpx4_-5i6kObgyOhn26Uh_A5xgzc--oKnNOzGlKdtKGPBv8K8xc7nn8HZATsb645zKN9xiHjeevywxFCCjdU3LcNrxyk66O1Q_NnbPEGPN18erm_J_bevd9dX98RxkDNpqBXUdQ34ddtLKS2TXQf1K9Fz50FpRb0QjrXM93rdN1zYVoHvWiUYddLyE_Rpnzvl9GPxZTZPacmxVhqmNaVNIzmrKrZXuZxKyb43Uw6jzTtDwbwwNnvGpjI2r4yNqqaLt-ilG_36r-UdahXwvaDUU9z4_K_7P7F_AMEyiTY</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Helaoui, Ahlem</creator><creator>Sfar, Sana</creator><creator>Boudhiba, Najet</creator><creator>Dehghanian, Fariba</creator><creator>Dehbashi, Moein</creator><creator>Bouchahda, Haifa</creator><creator>Hojati, Zohreh</creator><creator>Kenani, Abderraouf</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0002-1647-5495</orcidid></search><sort><creationdate>20230201</creationdate><title>Association of xenobiotic-metabolizing genes polymorphisms with cervical cancer risk in the Tunisian population</title><author>Helaoui, Ahlem ; Sfar, Sana ; Boudhiba, Najet ; Dehghanian, Fariba ; Dehbashi, Moein ; Bouchahda, Haifa ; Hojati, Zohreh ; Kenani, Abderraouf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-81a41cb80ed9f555a25bb09784f3ce06761e44c292ef7df834a960eb96421c5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>AhR gene</topic><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Carcinogenesis</topic><topic>Case-Control Studies</topic><topic>Cervical cancer</topic><topic>Cytochrome P-450 CYP1A1 - genetics</topic><topic>Cytochrome P450</topic><topic>Environmental factors</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Genes</topic><topic>Genetic diversity</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Glutathione Transferase - genetics</topic><topic>GSTM1 protein</topic><topic>GSTT1 protein</topic><topic>Histology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Morphology</topic><topic>Original Article</topic><topic>Polymerase chain reaction</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Population genetics</topic><topic>Restriction fragment length polymorphism</topic><topic>Risk Factors</topic><topic>Single-nucleotide polymorphism</topic><topic>Tumorigenesis</topic><topic>Uterine Cervical Neoplasms - genetics</topic><topic>Xenobiotics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Helaoui, Ahlem</creatorcontrib><creatorcontrib>Sfar, Sana</creatorcontrib><creatorcontrib>Boudhiba, Najet</creatorcontrib><creatorcontrib>Dehghanian, Fariba</creatorcontrib><creatorcontrib>Dehbashi, Moein</creatorcontrib><creatorcontrib>Bouchahda, Haifa</creatorcontrib><creatorcontrib>Hojati, Zohreh</creatorcontrib><creatorcontrib>Kenani, Abderraouf</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Helaoui, Ahlem</au><au>Sfar, Sana</au><au>Boudhiba, Najet</au><au>Dehghanian, Fariba</au><au>Dehbashi, Moein</au><au>Bouchahda, Haifa</au><au>Hojati, Zohreh</au><au>Kenani, Abderraouf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of xenobiotic-metabolizing genes polymorphisms with cervical cancer risk in the Tunisian population</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2023-02-01</date><risdate>2023</risdate><volume>50</volume><issue>2</issue><spage>949</spage><epage>959</epage><pages>949-959</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>Background
Host genetic characteristics and environmental factors interactions may play a crucial role in cervical carcinogenesis. We investigated the impact of functional genetic variants of four xenobiotic-metabolizing genes (
AhR
,
CYP1A1
,
GSTM1
, and
GSTT1
) on cervical cancer development in Tunisian women.
Methods
The
AhR
gene polymorphism was analyzed using the tetra-primer ARMS-PCR, whereas the
CYP1A1
polymorphism genotypes were identified by PCR-RFLP. A multiplex ligation-dependent polymerase chain reaction approach was applied for the analysis of
GSTM1
and
GSTT1
polymorphisms.
Results
The homozygous A/A genotype of the
AhR
gene (rs2066853) and the heterozygous T/C genotype of the
CYP1A1
SNP (
CYP1A1-MspI
) appeared to be associated with an increased risk of cervical tumorigenesis (OR
a
= 2.81; OR
a
= 5.52, respectively). Furthermore, a significantly increased risk of cervical cancer was associated with the
GSTT1
null genotype (OR
a
= 2.65). However, the null
GSTM1
genotype showed any significant association with the risk of cervical cancer compared to the wild genotype (OR
a
= 1.18;
p
= 0.784). Considering the combined effect, we noted a significantly higher association with cancer risk for individuals with at least two high-risk genotypes of CYP1A1/GSTT1 (OR
a
= 4.2), individuals with at least two high-risk genotypes of CYP1A1/GSTT1/AhR (OR
a
= 11.3) and individuals with at least two high-risk genotypes of CYP1A1/GSTM1/GSTT1/AhR exploitation low-risk genotype as a reference.
Conclusion
This study indicated that the single-gene contribution and the combined effect of xenobiotic-metabolizing gene polymorphisms (
AhR
,
CYP1A1-MspI
,
GSTM1
, and
GSTT1
) may have a considerable association with increased cervical cancer risk.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>36376536</pmid><doi>10.1007/s11033-022-07945-6</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-1647-5495</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Molecular biology reports, 2023-02, Vol.50 (2), p.949-959 |
| issn | 0301-4851 1573-4978 |
| language | eng |
| recordid | cdi_proquest_journals_2771188532 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | AhR gene Animal Anatomy Animal Biochemistry Biomedical and Life Sciences Carcinogenesis Case-Control Studies Cervical cancer Cytochrome P-450 CYP1A1 - genetics Cytochrome P450 Environmental factors Female Gene polymorphism Genes Genetic diversity Genetic Predisposition to Disease Genotype Genotype & phenotype Glutathione Transferase - genetics GSTM1 protein GSTT1 protein Histology Humans Life Sciences Morphology Original Article Polymerase chain reaction Polymorphism Polymorphism, Genetic Population genetics Restriction fragment length polymorphism Risk Factors Single-nucleotide polymorphism Tumorigenesis Uterine Cervical Neoplasms - genetics Xenobiotics |
| title | Association of xenobiotic-metabolizing genes polymorphisms with cervical cancer risk in the Tunisian population |
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