Convergent synthesis of the [5-7-6-3] tetracyclic core of premyrsinane diterpenes

The [5-7-6-3] tetracyclic core of premyrsinane diterpenes was convergently synthesized via the stereoselective three-component coupling of a 2-propenyl unit, an enone, and an aldehyde, followed by the relay ring-closing metathesis with conformation control of the substrate to construct the 7-membered ring. The [5-7-6-3] tetracyclic core of premyrsinane diterpenes was synthesized via three-component coupling and relay ring-closing metathesis.