Design of diastereomeric salt resolution via multicomponent system characterization: a case study with hydrate formation

Diastereomeric salt crystallization is a convenient method to resolve chiral drug substances when other separation methods like preferential crystallization and solid-state deracemization cannot be applied directly. This is the case of the antiepileptic pregabalin, which is a racemate-forming compou...

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Veröffentlicht in:	CrystEngComm 2023-01, Vol.25 (4), p.641-652
Hauptverfasser:	Bosits, Miklós H., Bereczki, Laura, Bombicz, Petra, Szalay, Zsófia, Pataki, Hajnalka, Demeter, Ádám
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystallization Enantiomers Phase diagrams Process parameters Quaternary systems Selectivity Solubility Tartaric acid Thermodynamic models
Online-Zugang:	Volltext
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