Follicular fluid biomarkers for prediction of human IVF outcome in women with poor ovarian response
Background The aim of controlled ovarian stimulation is to achieve an optimal number of mature oocytes to obtain good-quality embryos. High follicular fluid (FF) concentrations of FSH, hCG, and LH promote oocyte maturation and are associated with a higher probability of fertilization. LH concentrati...
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| Veröffentlicht in: | Middle East Fertility Society Journal 2023-12, Vol.28 (1), p.2-11, Article 2 |
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| creator | Barroso-Villa, Gerardo Valdespin-Fierro, Carlos Weiser-Smeke, Ariane-Estrella Machargo-Gordillo, Ana-Paula Flores-Pliego, Arturo Palma-Lara, Icela Oehninger, Sergio |
| description | Background
The aim of controlled ovarian stimulation is to achieve an optimal number of mature oocytes to obtain good-quality embryos. High follicular fluid (FF) concentrations of FSH, hCG, and LH promote oocyte maturation and are associated with a higher probability of fertilization. LH concentrations in FF are consistently higher in follicles that will lead to a successful IVF outcome. The levels of some of these FF biomarkers may vary among different ovarian stimulation schemes; however, the effects of corifollitropin alfa, recombinant FSH (rFSH), LH (rLH), and highly purified urinary menotropins uhMG on these biomarkers are still unknown. The objective of this study was to characterize the profile of FF biomarkers (leptin, vascular endothelial growth factor (VEGF), metalloproteinases (MMPs), and NO2−/NO3−) according to three different protocols of controlled ovarian stimulation (COS) in poor ovarian responders (POR) and to evaluate the association between these profiles and clinical outcomes. Three groups of POR patients were examined according to the protocols used.
Results
Group C showed significant higher levels in all biomarkers (
p
< 0001). FF samples from Group B had the lowest levels of VEGF and Pro-MMP-9. Group A showed the lowest concentration of pro-MMP-2. The VEGF level and number of captured oocytes were positively correlated in Group C (
r
= 0.534,
p
= 0.01). MMP-9 and fertilization rate were negatively correlated in Group C (
r
= −0.476,
p
= 0.02). We found negative correlations between proMMP-2 and serum estradiol levels on the day of rhCG administration.
Conclusion
We found significant variations in the biomarker concentrations between the different controlled ovarian stimulation schemes used in POR patients. These differences can be potentially explained by the nature and composition of the gonadotropins. Our results support the hypothesis that some of these molecules should be thoroughly investigated as noninvasive predictors of egg quality. |
| doi_str_mv | 10.1186/s43043-023-00128-8 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_proquest_journals_2767700054</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A734296081</galeid><doaj_id>oai_doaj_org_article_9555fb6883004792bd95c6f6982529f7</doaj_id><sourcerecordid>A734296081</sourcerecordid><originalsourceid>FETCH-LOGICAL-c377t-b641271ee5dc081160c2f794a513603ca296876d017c6349d2225c49651c3c423</originalsourceid><addsrcrecordid>eNp9UU2LFDEUbETBdfUPeAp47vXlOzkui6MDC17Ua8ikk9mM3f3GpFvx3xu3xVUQCckLj6qiiuq6lxSuKDXqdRUcBO-BtQuUmd486i4YWOg5k_TxH_-n3bNaTwDcMA4XXdjhOOawjr6QNK55IIeMky-fY6kkYSHnEocclowzwUTu1snPZP9pR3BdAk6R5Jl8a7O9ebkjZ2wU_OpLbrAS6xnnGp93T5Ifa3zxa152H3dvPty862_fv93fXN_2gWu99AclKNM0RjkEMJQqCCxpK7ykXAEPnllltBqA6qC4sANjTAZhlaSBB8H4ZbffdAf0J3cuueX47tBnd7_AcnS-LDmM0VkpZTooYziA0JYdBiuDSsoaJplNumm92rTOBb-ssS7uhGuZm33HtNIaAKR4QB19E81zwqX4MOUa3LXmohluQRrq6h-odoY45YBzTLnt_yKwjRAK1lpi-h2GgvvZt9v6dq1vd9-3M43EN1Jt4PkYy4Pj_7B-AAnBqcI</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2767700054</pqid></control><display><type>article</type><title>Follicular fluid biomarkers for prediction of human IVF outcome in women with poor ovarian response</title><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>Alma/SFX Local Collection</source><creator>Barroso-Villa, Gerardo ; Valdespin-Fierro, Carlos ; Weiser-Smeke, Ariane-Estrella ; Machargo-Gordillo, Ana-Paula ; Flores-Pliego, Arturo ; Palma-Lara, Icela ; Oehninger, Sergio</creator><creatorcontrib>Barroso-Villa, Gerardo ; Valdespin-Fierro, Carlos ; Weiser-Smeke, Ariane-Estrella ; Machargo-Gordillo, Ana-Paula ; Flores-Pliego, Arturo ; Palma-Lara, Icela ; Oehninger, Sergio</creatorcontrib><description>Background
The aim of controlled ovarian stimulation is to achieve an optimal number of mature oocytes to obtain good-quality embryos. High follicular fluid (FF) concentrations of FSH, hCG, and LH promote oocyte maturation and are associated with a higher probability of fertilization. LH concentrations in FF are consistently higher in follicles that will lead to a successful IVF outcome. The levels of some of these FF biomarkers may vary among different ovarian stimulation schemes; however, the effects of corifollitropin alfa, recombinant FSH (rFSH), LH (rLH), and highly purified urinary menotropins uhMG on these biomarkers are still unknown. The objective of this study was to characterize the profile of FF biomarkers (leptin, vascular endothelial growth factor (VEGF), metalloproteinases (MMPs), and NO2−/NO3−) according to three different protocols of controlled ovarian stimulation (COS) in poor ovarian responders (POR) and to evaluate the association between these profiles and clinical outcomes. Three groups of POR patients were examined according to the protocols used.
Results
Group C showed significant higher levels in all biomarkers (
p
< 0001). FF samples from Group B had the lowest levels of VEGF and Pro-MMP-9. Group A showed the lowest concentration of pro-MMP-2. The VEGF level and number of captured oocytes were positively correlated in Group C (
r
= 0.534,
p
= 0.01). MMP-9 and fertilization rate were negatively correlated in Group C (
r
= −0.476,
p
= 0.02). We found negative correlations between proMMP-2 and serum estradiol levels on the day of rhCG administration.
Conclusion
We found significant variations in the biomarker concentrations between the different controlled ovarian stimulation schemes used in POR patients. These differences can be potentially explained by the nature and composition of the gonadotropins. Our results support the hypothesis that some of these molecules should be thoroughly investigated as noninvasive predictors of egg quality.</description><identifier>ISSN: 2090-3251</identifier><identifier>ISSN: 1110-5690</identifier><identifier>EISSN: 2090-3251</identifier><identifier>DOI: 10.1186/s43043-023-00128-8</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biological markers ; Biomarkers ; Clinical outcomes ; Embryos ; Fertilization in vitro ; Follicular fluid ; Gonadotropin ; In vitro fertilization ; IVF ; Leptin ; Medicine ; Medicine & Public Health ; Nitrogen oxide ; Ovaries ; Patients ; Pharmaceutical industry ; Poor ovarian responders ; POSEIDON criteria ; Pregnancy ; Vascular endothelial growth factor ; Women</subject><ispartof>Middle East Fertility Society Journal, 2023-12, Vol.28 (1), p.2-11, Article 2</ispartof><rights>The Author(s) 2023</rights><rights>COPYRIGHT 2023 Springer</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c377t-b641271ee5dc081160c2f794a513603ca296876d017c6349d2225c49651c3c423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>Barroso-Villa, Gerardo</creatorcontrib><creatorcontrib>Valdespin-Fierro, Carlos</creatorcontrib><creatorcontrib>Weiser-Smeke, Ariane-Estrella</creatorcontrib><creatorcontrib>Machargo-Gordillo, Ana-Paula</creatorcontrib><creatorcontrib>Flores-Pliego, Arturo</creatorcontrib><creatorcontrib>Palma-Lara, Icela</creatorcontrib><creatorcontrib>Oehninger, Sergio</creatorcontrib><title>Follicular fluid biomarkers for prediction of human IVF outcome in women with poor ovarian response</title><title>Middle East Fertility Society Journal</title><addtitle>Middle East Fertil Soc J</addtitle><description>Background
The aim of controlled ovarian stimulation is to achieve an optimal number of mature oocytes to obtain good-quality embryos. High follicular fluid (FF) concentrations of FSH, hCG, and LH promote oocyte maturation and are associated with a higher probability of fertilization. LH concentrations in FF are consistently higher in follicles that will lead to a successful IVF outcome. The levels of some of these FF biomarkers may vary among different ovarian stimulation schemes; however, the effects of corifollitropin alfa, recombinant FSH (rFSH), LH (rLH), and highly purified urinary menotropins uhMG on these biomarkers are still unknown. The objective of this study was to characterize the profile of FF biomarkers (leptin, vascular endothelial growth factor (VEGF), metalloproteinases (MMPs), and NO2−/NO3−) according to three different protocols of controlled ovarian stimulation (COS) in poor ovarian responders (POR) and to evaluate the association between these profiles and clinical outcomes. Three groups of POR patients were examined according to the protocols used.
Results
Group C showed significant higher levels in all biomarkers (
p
< 0001). FF samples from Group B had the lowest levels of VEGF and Pro-MMP-9. Group A showed the lowest concentration of pro-MMP-2. The VEGF level and number of captured oocytes were positively correlated in Group C (
r
= 0.534,
p
= 0.01). MMP-9 and fertilization rate were negatively correlated in Group C (
r
= −0.476,
p
= 0.02). We found negative correlations between proMMP-2 and serum estradiol levels on the day of rhCG administration.
Conclusion
We found significant variations in the biomarker concentrations between the different controlled ovarian stimulation schemes used in POR patients. These differences can be potentially explained by the nature and composition of the gonadotropins. Our results support the hypothesis that some of these molecules should be thoroughly investigated as noninvasive predictors of egg quality.</description><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Clinical outcomes</subject><subject>Embryos</subject><subject>Fertilization in vitro</subject><subject>Follicular fluid</subject><subject>Gonadotropin</subject><subject>In vitro fertilization</subject><subject>IVF</subject><subject>Leptin</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nitrogen oxide</subject><subject>Ovaries</subject><subject>Patients</subject><subject>Pharmaceutical industry</subject><subject>Poor ovarian responders</subject><subject>POSEIDON criteria</subject><subject>Pregnancy</subject><subject>Vascular endothelial growth factor</subject><subject>Women</subject><issn>2090-3251</issn><issn>1110-5690</issn><issn>2090-3251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNp9UU2LFDEUbETBdfUPeAp47vXlOzkui6MDC17Ua8ikk9mM3f3GpFvx3xu3xVUQCckLj6qiiuq6lxSuKDXqdRUcBO-BtQuUmd486i4YWOg5k_TxH_-n3bNaTwDcMA4XXdjhOOawjr6QNK55IIeMky-fY6kkYSHnEocclowzwUTu1snPZP9pR3BdAk6R5Jl8a7O9ebkjZ2wU_OpLbrAS6xnnGp93T5Ifa3zxa152H3dvPty862_fv93fXN_2gWu99AclKNM0RjkEMJQqCCxpK7ykXAEPnllltBqA6qC4sANjTAZhlaSBB8H4ZbffdAf0J3cuueX47tBnd7_AcnS-LDmM0VkpZTooYziA0JYdBiuDSsoaJplNumm92rTOBb-ssS7uhGuZm33HtNIaAKR4QB19E81zwqX4MOUa3LXmohluQRrq6h-odoY45YBzTLnt_yKwjRAK1lpi-h2GgvvZt9v6dq1vd9-3M43EN1Jt4PkYy4Pj_7B-AAnBqcI</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Barroso-Villa, Gerardo</creator><creator>Valdespin-Fierro, Carlos</creator><creator>Weiser-Smeke, Ariane-Estrella</creator><creator>Machargo-Gordillo, Ana-Paula</creator><creator>Flores-Pliego, Arturo</creator><creator>Palma-Lara, Icela</creator><creator>Oehninger, Sergio</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>DOA</scope></search><sort><creationdate>20231201</creationdate><title>Follicular fluid biomarkers for prediction of human IVF outcome in women with poor ovarian response</title><author>Barroso-Villa, Gerardo ; Valdespin-Fierro, Carlos ; Weiser-Smeke, Ariane-Estrella ; Machargo-Gordillo, Ana-Paula ; Flores-Pliego, Arturo ; Palma-Lara, Icela ; Oehninger, Sergio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-b641271ee5dc081160c2f794a513603ca296876d017c6349d2225c49651c3c423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Clinical outcomes</topic><topic>Embryos</topic><topic>Fertilization in vitro</topic><topic>Follicular fluid</topic><topic>Gonadotropin</topic><topic>In vitro fertilization</topic><topic>IVF</topic><topic>Leptin</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nitrogen oxide</topic><topic>Ovaries</topic><topic>Patients</topic><topic>Pharmaceutical industry</topic><topic>Poor ovarian responders</topic><topic>POSEIDON criteria</topic><topic>Pregnancy</topic><topic>Vascular endothelial growth factor</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barroso-Villa, Gerardo</creatorcontrib><creatorcontrib>Valdespin-Fierro, Carlos</creatorcontrib><creatorcontrib>Weiser-Smeke, Ariane-Estrella</creatorcontrib><creatorcontrib>Machargo-Gordillo, Ana-Paula</creatorcontrib><creatorcontrib>Flores-Pliego, Arturo</creatorcontrib><creatorcontrib>Palma-Lara, Icela</creatorcontrib><creatorcontrib>Oehninger, Sergio</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Middle East Fertility Society Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barroso-Villa, Gerardo</au><au>Valdespin-Fierro, Carlos</au><au>Weiser-Smeke, Ariane-Estrella</au><au>Machargo-Gordillo, Ana-Paula</au><au>Flores-Pliego, Arturo</au><au>Palma-Lara, Icela</au><au>Oehninger, Sergio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Follicular fluid biomarkers for prediction of human IVF outcome in women with poor ovarian response</atitle><jtitle>Middle East Fertility Society Journal</jtitle><stitle>Middle East Fertil Soc J</stitle><date>2023-12-01</date><risdate>2023</risdate><volume>28</volume><issue>1</issue><spage>2</spage><epage>11</epage><pages>2-11</pages><artnum>2</artnum><issn>2090-3251</issn><issn>1110-5690</issn><eissn>2090-3251</eissn><abstract>Background
The aim of controlled ovarian stimulation is to achieve an optimal number of mature oocytes to obtain good-quality embryos. High follicular fluid (FF) concentrations of FSH, hCG, and LH promote oocyte maturation and are associated with a higher probability of fertilization. LH concentrations in FF are consistently higher in follicles that will lead to a successful IVF outcome. The levels of some of these FF biomarkers may vary among different ovarian stimulation schemes; however, the effects of corifollitropin alfa, recombinant FSH (rFSH), LH (rLH), and highly purified urinary menotropins uhMG on these biomarkers are still unknown. The objective of this study was to characterize the profile of FF biomarkers (leptin, vascular endothelial growth factor (VEGF), metalloproteinases (MMPs), and NO2−/NO3−) according to three different protocols of controlled ovarian stimulation (COS) in poor ovarian responders (POR) and to evaluate the association between these profiles and clinical outcomes. Three groups of POR patients were examined according to the protocols used.
Results
Group C showed significant higher levels in all biomarkers (
p
< 0001). FF samples from Group B had the lowest levels of VEGF and Pro-MMP-9. Group A showed the lowest concentration of pro-MMP-2. The VEGF level and number of captured oocytes were positively correlated in Group C (
r
= 0.534,
p
= 0.01). MMP-9 and fertilization rate were negatively correlated in Group C (
r
= −0.476,
p
= 0.02). We found negative correlations between proMMP-2 and serum estradiol levels on the day of rhCG administration.
Conclusion
We found significant variations in the biomarker concentrations between the different controlled ovarian stimulation schemes used in POR patients. These differences can be potentially explained by the nature and composition of the gonadotropins. Our results support the hypothesis that some of these molecules should be thoroughly investigated as noninvasive predictors of egg quality.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43043-023-00128-8</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological markers Biomarkers Clinical outcomes Embryos Fertilization in vitro Follicular fluid Gonadotropin In vitro fertilization IVF Leptin Medicine Medicine & Public Health Nitrogen oxide Ovaries Patients Pharmaceutical industry Poor ovarian responders POSEIDON criteria Pregnancy Vascular endothelial growth factor Women |
| title | Follicular fluid biomarkers for prediction of human IVF outcome in women with poor ovarian response |
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