Functional Peptides from One-bead One-compound High-throughput Screening Technique
C ombinatorial chemistry provides a cost-effective method for the rapid discovery of new functional peptides. One-bead one-compound(OBOC) high-throughput screening technique offers a lot of structurally diverse peptides to be rapidly synthesized and screened for binding to a target of interest. The...
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| Veröffentlicht in: | Chemical research in Chinese universities 2023-02, Vol.39 (1), p.83-91 |
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| creator | Yan, Yaqiong Wang, Lei Wang, Hao |
| description | C
ombinatorial chemistry provides a cost-effective method for the rapid discovery of new functional peptides. One-bead one-compound(OBOC) high-throughput screening technique offers a lot of structurally diverse peptides to be rapidly synthesized and screened for binding to a target of interest. The OBOC peptide library screening involves three main steps: library construction, positive beads separation, and peptide sequencing. This review mainly summarizes some special technique tips during functional peptide screening and potential future directions of the OBOC high-throughput screening technique. |
| doi_str_mv | 10.1007/s40242-023-2356-2 |
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ombinatorial chemistry provides a cost-effective method for the rapid discovery of new functional peptides. One-bead one-compound(OBOC) high-throughput screening technique offers a lot of structurally diverse peptides to be rapidly synthesized and screened for binding to a target of interest. The OBOC peptide library screening involves three main steps: library construction, positive beads separation, and peptide sequencing. This review mainly summarizes some special technique tips during functional peptide screening and potential future directions of the OBOC high-throughput screening technique.</description><identifier>ISSN: 1005-9040</identifier><identifier>EISSN: 2210-3171</identifier><identifier>DOI: 10.1007/s40242-023-2356-2</identifier><language>eng</language><publisher>Changchun: Jilin University and The Editorial Department of Chemical Research in Chinese Universities</publisher><subject>Analytical Chemistry ; Beads ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Combinatorial analysis ; Combinatorial chemistry ; Inorganic Chemistry ; Libraries ; Organic Chemistry ; Peptides ; Physical Chemistry ; Review ; Screening</subject><ispartof>Chemical research in Chinese universities, 2023-02, Vol.39 (1), p.83-91</ispartof><rights>Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2023</rights><rights>Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2023.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-4b25512d39416408ee999951a7ce7df5bf013de1933962119488de1b8d653a543</citedby><cites>FETCH-LOGICAL-c316t-4b25512d39416408ee999951a7ce7df5bf013de1933962119488de1b8d653a543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40242-023-2356-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40242-023-2356-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Yan, Yaqiong</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Wang, Hao</creatorcontrib><title>Functional Peptides from One-bead One-compound High-throughput Screening Technique</title><title>Chemical research in Chinese universities</title><addtitle>Chem. Res. Chin. Univ</addtitle><description>C
ombinatorial chemistry provides a cost-effective method for the rapid discovery of new functional peptides. One-bead one-compound(OBOC) high-throughput screening technique offers a lot of structurally diverse peptides to be rapidly synthesized and screened for binding to a target of interest. The OBOC peptide library screening involves three main steps: library construction, positive beads separation, and peptide sequencing. This review mainly summarizes some special technique tips during functional peptide screening and potential future directions of the OBOC high-throughput screening technique.</description><subject>Analytical Chemistry</subject><subject>Beads</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Combinatorial analysis</subject><subject>Combinatorial chemistry</subject><subject>Inorganic Chemistry</subject><subject>Libraries</subject><subject>Organic Chemistry</subject><subject>Peptides</subject><subject>Physical Chemistry</subject><subject>Review</subject><subject>Screening</subject><issn>1005-9040</issn><issn>2210-3171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1UMlOwzAQtRBIlMIHcIvE2eDxluSIKkqRKhVBOVtZJkvV2sFODvw9LkXixBxmkd57M_MIuQV2D4ylD0EyLjllXFAulKb8jMw4B0YFpHBOZhGkaM4kuyRXIewYE7nWckbelpOtxt7ZYp-84jD2NYak8e6QbCzSEov6p6ncYXCTrZNV33Z07Lyb2m6YxuS98oi2t22yxaqz_eeE1-SiKfYBb37rnHwsn7aLFV1vnl8Wj2taCdAjlSVXCngtcglasgwxj6GgSCtM60aVDQNRI-QinsoBcpllcSyzWitRKCnm5O6kO3gX14bR7Nzk4yPB8FSnSqcaVETBCVV5F4LHxgy-PxT-ywAzR-vMyToTrTNH62KaE37ihIi1Lfo_5f9J3wt4b-o</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Yan, Yaqiong</creator><creator>Wang, Lei</creator><creator>Wang, Hao</creator><general>Jilin University and The Editorial Department of Chemical Research in Chinese Universities</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20230201</creationdate><title>Functional Peptides from One-bead One-compound High-throughput Screening Technique</title><author>Yan, Yaqiong ; Wang, Lei ; Wang, Hao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-4b25512d39416408ee999951a7ce7df5bf013de1933962119488de1b8d653a543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Analytical Chemistry</topic><topic>Beads</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Combinatorial analysis</topic><topic>Combinatorial chemistry</topic><topic>Inorganic Chemistry</topic><topic>Libraries</topic><topic>Organic Chemistry</topic><topic>Peptides</topic><topic>Physical Chemistry</topic><topic>Review</topic><topic>Screening</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yan, Yaqiong</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Wang, Hao</creatorcontrib><collection>CrossRef</collection><jtitle>Chemical research in Chinese universities</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan, Yaqiong</au><au>Wang, Lei</au><au>Wang, Hao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional Peptides from One-bead One-compound High-throughput Screening Technique</atitle><jtitle>Chemical research in Chinese universities</jtitle><stitle>Chem. Res. Chin. Univ</stitle><date>2023-02-01</date><risdate>2023</risdate><volume>39</volume><issue>1</issue><spage>83</spage><epage>91</epage><pages>83-91</pages><issn>1005-9040</issn><eissn>2210-3171</eissn><abstract>C
ombinatorial chemistry provides a cost-effective method for the rapid discovery of new functional peptides. One-bead one-compound(OBOC) high-throughput screening technique offers a lot of structurally diverse peptides to be rapidly synthesized and screened for binding to a target of interest. The OBOC peptide library screening involves three main steps: library construction, positive beads separation, and peptide sequencing. This review mainly summarizes some special technique tips during functional peptide screening and potential future directions of the OBOC high-throughput screening technique.</abstract><cop>Changchun</cop><pub>Jilin University and The Editorial Department of Chemical Research in Chinese Universities</pub><doi>10.1007/s40242-023-2356-2</doi><tpages>9</tpages></addata></record> |
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| subjects | Analytical Chemistry Beads Chemistry Chemistry and Materials Science Chemistry/Food Science Combinatorial analysis Combinatorial chemistry Inorganic Chemistry Libraries Organic Chemistry Peptides Physical Chemistry Review Screening |
| title | Functional Peptides from One-bead One-compound High-throughput Screening Technique |
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