Development of an LC/MS/MS Method for Simultaneous Detection of 11 Polyphenols in Rat Plasma and Its Pharmacokinetic Application after Oral Administration of Coreopsis tinctoria Extract

Eleven polyphenols, classified as flavonoid glycosides, flavonoid aglycones, and phenolic acids, are important bioactive components in the capitula of Coreopsis tinctoria (CCT). Nevertheless, their full pharmacokinetic profiles have not been demonstrated simultaneously. Therefore, a liquid chromatog...

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Veröffentlicht in:	Chemistry & biodiversity 2023-01, Vol.20 (1), p.e202200574-n/a
Hauptverfasser:	Han, Haixia, Ma, Rui, Xie, Aidi, Gao, Juanjuan, Wang, Zhen, Zhao, Yi, Pang, Huanming, Zhang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitrile Administration, Oral Aglycones Analytical chemistry Animals Biological activity biological sample analysis Chromatography, High Pressure Liquid Chromatography, Liquid - methods Coreopsis Coreopsis tinctoria Correlation coefficient Correlation coefficients Drugs, Chinese Herbal - chemistry Ethanol Flavone glycosides Flavonoids Flavonoids - chemistry Formic acid Glycosides Glycosides - chemistry LC/MS/MS Liquid chromatography Mass spectrometry Mass spectroscopy multi-component pharmacokinetics Oral administration Pharmacokinetics Pharmacology Phenolic acids Phenols Plasma levels Polyphenols Rats Selectivity Tandem Mass Spectrometry - methods
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