A Novel and Simple Synthesis of Ethers of Hydroxypyridines with Hexafluoropropan-2-ol via Diazotization of Aminopyridines and Aminoquinolines Under Acid-Free Conditions

A Novel and Simple Synthesis of Ethers of Hydroxypyridines with Hexafluoropropan-2-ol via Diazotization of Aminopyridines and Aminoquinolines Under Acid-Free Conditions

Herein, we report the first example of diazotization of aminopyridines and aminoquinolines with t -BuONO in hexafluoropropan-2-ol in the absence of acids or other initiators. For aminopyridines, this reaction is the first general route toward 2-, 3-, and 4-[(1,1,1,3,3,3-hexafluoropropan-2-yl)oxy]pyr...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2022-12, Vol.58 (12), p.721-726
Hauptverfasser: Filimonov, Victor D., Sanzhiev, Aldar N., Gulyaev, Roman O., Krasnokutskaya, Elena A., Bondarev, Alexander A.
Format: Artikel
Sprache:eng
Schlagworte:
Aminoquinolines
Chemistry
Chemistry and Materials Science
Ethers
Organic Chemistry
Pharmacy
Pyridine
Pyridines
Quinoline
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Zusammenfassung:Herein, we report the first example of diazotization of aminopyridines and aminoquinolines with t -BuONO in hexafluoropropan-2-ol in the absence of acids or other initiators. For aminopyridines, this reaction is the first general route toward 2-, 3-, and 4-[(1,1,1,3,3,3-hexafluoropropan-2-yl)oxy]pyridines.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-023-03148-4