Combined-modality treatment for locally advanced cervical cancer in a woman with Bloom-like syndrome: A case report and review of the literature
We report the case of a 46-year-old woman with Bloom-like syndrome affected with locally advanced cervical cancer. She was treated with induction chemotherapy and radical radiation therapy concurrent with chemotherapy (carboplatin and paclitaxel). She was able to complete treatment, but grade III to...
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| Veröffentlicht in: | Strahlentherapie und Onkologie 2023, Vol.199 (1), p.102-105 |
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| container_title | Strahlentherapie und Onkologie |
| container_volume | 199 |
| creator | Ben Dhia, Syrine Berthou, Hugo Warcoin, Mathilde Rodrigues, Manuel Noret, Aurélien Beddok, Arnaud Weber, Nina Stoppa Lyonnet, Dominique Scher, Nathaniel |
| description | We report the case of a 46-year-old woman with Bloom-like syndrome affected with locally advanced cervical cancer. She was treated with induction chemotherapy and radical radiation therapy concurrent with chemotherapy (carboplatin and paclitaxel). She was able to complete treatment, but grade III toxicities were observed. The limited relevant literature is presented. We conclude that the management of patients with DNA repair deficiency is challenging for the team in charge because of the potentially high sensitivity to treatment and the lack of clear recommendations in the literature. The main objective remains to deliver the optimal treatment while reducing toxicities. |
| doi_str_mv | 10.1007/s00066-022-01981-8 |
| format | Article |
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| ispartof | Strahlentherapie und Onkologie, 2023, Vol.199 (1), p.102-105 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Anemia Antineoplastic Combined Chemotherapy Protocols - therapeutic use Breast cancer Cancer Cancer therapies Carboplatin - therapeutic use Case reports Case Study Cervical cancer Chemotherapy Combined Modality Therapy DNA repair Female Genetic disorders Humans Leukemia Literature reviews Lymphoma Mammography Medicine Medicine & Public Health Middle Aged Oncology Paclitaxel - therapeutic use Patients Proteins Radiation therapy Radiotherapy Squamous cell carcinoma Surgery Uterine Cervical Neoplasms - radiotherapy |
| title | Combined-modality treatment for locally advanced cervical cancer in a woman with Bloom-like syndrome: A case report and review of the literature |
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