Solvent-free synthesis, molecular simulation and cytotoxicity of 1,4-benzodiazepine-2,5-diones

he reaction of anthranilic acid with proline or pipecolinic methyl ester hydrochloride in presence of 1,1’-Carbonyldiimidazole (CDI) on oil bath heating under solvent-free condition afforded 1,4-benzodiazepine-2,5-dione (BZD) derivatives in moderate to good yields. Operational simplicity, absence of...

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Veröffentlicht in:	Organic communications 2022-04, Vol.15 (2), p.204-211
Hauptverfasser:	Shabeer, Timiri Khudus, Khaja Mohideen, Abbas, Mohammed Mustaque, Kasim, Salim Meeran, Ismail, Subramani, Annadurai, Jamal Ahamed, V. S., Thajudeen, Habeebullah
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Anthranilic acid Benzodiazepines Carbonyls Chemical synthesis Chemistry Chlorine compounds Chromatography Cytotoxicity Diketones Kinases Melanoma Molecular docking Ovaries Reagents Receptors Simulation Skin cancer Solvents Toxicity Tumor cell lines Vascular endothelial growth factor Vascular endothelial growth factor receptors
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