Secondary Metabolites from the Coral-Derived Fungus Aspergillus terreus SCSIO41404 with Pancreatic Lipase Inhibitory Activities
Ten secondary metabolites were isolated from cultures of the marine coral-derived fungus Aspergillus terreus SCSIO41404. The compounds were identified as monacolin K (1), methyl ester of lactone ring-opened monacolin K (2), asperterreusine C (3), 4-hydroxybenzaldehyde (4), 4-hydroxy-3-(3-methylbut-2...
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| Veröffentlicht in: | Records of natural products 2022-11, Vol.16 (6), p.639-644 |
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| creator | Zhou, Xuefeng Peng, Bo Peng, Qingyun Yang, Bin She, Jianglian |
| description | Ten secondary metabolites were isolated from cultures of the marine coral-derived fungus Aspergillus terreus SCSIO41404. The compounds were identified as monacolin K (1), methyl ester of lactone ring-opened monacolin K (2), asperterreusine C (3), 4-hydroxybenzaldehyde (4), 4-hydroxy-3-(3-methylbut-2-en-1-yl) benzaldehyde (5), kojic acid (6), p-hydroxyphenylacetic acid methyl ester (7), o-hydroxyphenylacetic acid methyl ester (8), N-(2-hydroxyphenyl)-acetamide (9), and (S)-methyl 2-acetamido-3-phenylpropanoate (10), by comparing the spectroscopic data with the reported literature values. They were evaluated for their cytotoxic, antibacterial, and enzyme (pancreatic lipase and acetylcholinesterase) inhibitory activities. Monacolin K (1) and its derivative (2) were revealed with obvious pancreatic lipase (PL) inhibitory effects. The in silico molecular docking with PL protein was further performed to understand the binding effects, and it is suggested that the ring opening of the monacolin K facilitates for the PL inhibitory activities. |
| doi_str_mv | 10.25135/rnp.312.22.01.2314 |
| format | Article |
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The compounds were identified as monacolin K (1), methyl ester of lactone ring-opened monacolin K (2), asperterreusine C (3), 4-hydroxybenzaldehyde (4), 4-hydroxy-3-(3-methylbut-2-en-1-yl) benzaldehyde (5), kojic acid (6), p-hydroxyphenylacetic acid methyl ester (7), o-hydroxyphenylacetic acid methyl ester (8), N-(2-hydroxyphenyl)-acetamide (9), and (S)-methyl 2-acetamido-3-phenylpropanoate (10), by comparing the spectroscopic data with the reported literature values. They were evaluated for their cytotoxic, antibacterial, and enzyme (pancreatic lipase and acetylcholinesterase) inhibitory activities. Monacolin K (1) and its derivative (2) were revealed with obvious pancreatic lipase (PL) inhibitory effects. The in silico molecular docking with PL protein was further performed to understand the binding effects, and it is suggested that the ring opening of the monacolin K facilitates for the PL inhibitory activities.</description><identifier>ISSN: 1307-6167</identifier><identifier>EISSN: 1307-6167</identifier><identifier>DOI: 10.25135/rnp.312.22.01.2314</identifier><language>eng</language><publisher>Gebze: ACG Publications</publisher><subject>Acids ; Chromatography ; Cytotoxicity ; Enzymes ; Fungi ; Geochemistry ; Hydrogen bonds ; Laboratories ; Metabolites ; Microorganisms ; Natural products ; Proteins ; Staphylococcus infections</subject><ispartof>Records of natural products, 2022-11, Vol.16 (6), p.639-644</ispartof><rights>2022. 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The compounds were identified as monacolin K (1), methyl ester of lactone ring-opened monacolin K (2), asperterreusine C (3), 4-hydroxybenzaldehyde (4), 4-hydroxy-3-(3-methylbut-2-en-1-yl) benzaldehyde (5), kojic acid (6), p-hydroxyphenylacetic acid methyl ester (7), o-hydroxyphenylacetic acid methyl ester (8), N-(2-hydroxyphenyl)-acetamide (9), and (S)-methyl 2-acetamido-3-phenylpropanoate (10), by comparing the spectroscopic data with the reported literature values. They were evaluated for their cytotoxic, antibacterial, and enzyme (pancreatic lipase and acetylcholinesterase) inhibitory activities. Monacolin K (1) and its derivative (2) were revealed with obvious pancreatic lipase (PL) inhibitory effects. The in silico molecular docking with PL protein was further performed to understand the binding effects, and it is suggested that the ring opening of the monacolin K facilitates for the PL inhibitory activities.</description><subject>Acids</subject><subject>Chromatography</subject><subject>Cytotoxicity</subject><subject>Enzymes</subject><subject>Fungi</subject><subject>Geochemistry</subject><subject>Hydrogen bonds</subject><subject>Laboratories</subject><subject>Metabolites</subject><subject>Microorganisms</subject><subject>Natural products</subject><subject>Proteins</subject><subject>Staphylococcus infections</subject><issn>1307-6167</issn><issn>1307-6167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpNkDtPwzAYRSMEEqXwC1gsMSf4kdrJWIVXpaIiFWbLcb60rtI42E4RE38dQxmY7hmu7pVOklwTnNEZYbNb1w8ZIzSjNMMko4zkJ8mEMCxSTrg4_cfnyYX3O4w5K0Q-Sb7WoG3fKPeJniGo2nYmgEets3sUtoAq61SX3oEzB2jQw9hvRo_mfgC3MV0XOYBzEHNdrRernOQ4Rx8mbNGL6rUDFYxGSzMoD2jRb01tgo1Xcx3MwQQD_jI5a1Xn4eovp8nbw_1r9ZQuV4-Lar5MNaM0pFAoVjSkLQUuW1aouhW1VrrRFFOMgQvBiZ61JSZ1gRkIXeZlUTS4FUQpLhibJjfH3cHZ9xF8kDs7uj5eSio4y0tacB5b7NjSznrvoJWDM_soRxIsf03LaFpG05JSiYn8Mc2-ATbHcyw</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Zhou, Xuefeng</creator><creator>Peng, Bo</creator><creator>Peng, Qingyun</creator><creator>Yang, Bin</creator><creator>She, Jianglian</creator><general>ACG Publications</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7WY</scope><scope>7XB</scope><scope>883</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FRNLG</scope><scope>K60</scope><scope>K6~</scope><scope>M0F</scope><scope>PIMPY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>20221101</creationdate><title>Secondary Metabolites from the Coral-Derived Fungus Aspergillus terreus SCSIO41404 with Pancreatic Lipase Inhibitory Activities</title><author>Zhou, Xuefeng ; 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The compounds were identified as monacolin K (1), methyl ester of lactone ring-opened monacolin K (2), asperterreusine C (3), 4-hydroxybenzaldehyde (4), 4-hydroxy-3-(3-methylbut-2-en-1-yl) benzaldehyde (5), kojic acid (6), p-hydroxyphenylacetic acid methyl ester (7), o-hydroxyphenylacetic acid methyl ester (8), N-(2-hydroxyphenyl)-acetamide (9), and (S)-methyl 2-acetamido-3-phenylpropanoate (10), by comparing the spectroscopic data with the reported literature values. They were evaluated for their cytotoxic, antibacterial, and enzyme (pancreatic lipase and acetylcholinesterase) inhibitory activities. Monacolin K (1) and its derivative (2) were revealed with obvious pancreatic lipase (PL) inhibitory effects. 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| subjects | Acids Chromatography Cytotoxicity Enzymes Fungi Geochemistry Hydrogen bonds Laboratories Metabolites Microorganisms Natural products Proteins Staphylococcus infections |
| title | Secondary Metabolites from the Coral-Derived Fungus Aspergillus terreus SCSIO41404 with Pancreatic Lipase Inhibitory Activities |
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