Biomarker‐Responsive Nanosystems for Chronic Disease Theranostics
Chronic diseases claim millions of lives every year, and it is of great significance to explore and develop advanced drugs to improve the cure rate of chronic diseases. Nanotheranostics are innovative strategies that enable the integration of diagnostic and therapeutic properties into a single nanos...
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| Veröffentlicht in: | Advanced functional materials 2023-01, Vol.33 (2), p.n/a |
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| creator | Fu, Qinrui Yu, Leilei Wang, Yin Li, Peifeng Song, Jibin |
| description | Chronic diseases claim millions of lives every year, and it is of great significance to explore and develop advanced drugs to improve the cure rate of chronic diseases. Nanotheranostics are innovative strategies that enable the integration of diagnostic and therapeutic properties into a single nanosystem. Despite great success in nanotheranostics, their applications of nanotheranostics in nanomedicine are still in their infancy. This is because each disease has its corresponding characteristic pathological microenvironment, which motivates the development of endogenous biomarker‐responsive nanosystems to meet the requirements of diagnosis and treatment. Herein, recent progress is presented in biomarker‐responsive nanosystems and their biomedical applications. First, biomarker‐responsive nanosystems are classified into eight subsections according to the type of chronic diseases, including tumors, cardiovascular diseases, neurological diseases, Wilson's diseases, chronic liver diseases, chronic kidney diseases, diabetes mellitus, and rheumatoid arthritis. In the following, a variety of intriguing applications of biomarkers‐responsive nanosystems are briefly elaborated, such as biosensing, diagnosis, therapy, combined theranostics, and early evaluation of therapy effect, etc. Finally, the challenges and future directions from research to clinical translation of these responsive nanosystems are also presented.
In this review, the biomarker‐responsive nanomaterials are summarized and reviewed for biomedical applications in various chronic diseases, including cancer, cardiovascular diseases, neurological diseases, Wilson's disease, chronic liver diseases, chronic kidney diseases, diabetes mellitus, and rheumatoid arthritis. |
| doi_str_mv | 10.1002/adfm.202206300 |
| format | Article |
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In this review, the biomarker‐responsive nanomaterials are summarized and reviewed for biomedical applications in various chronic diseases, including cancer, cardiovascular diseases, neurological diseases, Wilson's disease, chronic liver diseases, chronic kidney diseases, diabetes mellitus, and rheumatoid arthritis.</description><subject>Arthritis</subject><subject>Biomarkers</subject><subject>Biomedical materials</subject><subject>chronic diseases</subject><subject>Chronic illnesses</subject><subject>Diabetes mellitus</subject><subject>Diagnosis</subject><subject>Kidney diseases</subject><subject>Materials science</subject><subject>nanomaterials</subject><subject>Neurological diseases</subject><subject>pathological microenvironments</subject><subject>theranostics</subject><issn>1616-301X</issn><issn>1616-3028</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqFkMFOAjEQhhujiYhePW_ieXHasi094iJqgpoYTLw1y-5sKMIWO6Dh5iP4jD6JJRg8mkwyc_j-mfl_xs45dDiAuCyqetERIAQoCXDAWlxxlUoQvcP9zF-O2QnRDIBrLbstll85vyjCK4bvz68npKVvyL1j8lA0nja0wgUltQ9JPg2-cWUycIQFYTKeYtgiK1fSKTuqiznh2W9vs-fh9Ti_TUePN3d5f5SWkmtIdVUixvekFEbqrEIlFRpt6qxnQMpKakDd1VhmxqiCd_UEY1UTjhWPnrhss4vd3mXwb2uklZ35dWjiSSu0Er1McyMi1dlRZfBEAWu7DC5a3FgOdhuU3QZl90FFgdkJPtwcN__Qtj8Y3v9pfwAplWzu</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Fu, Qinrui</creator><creator>Yu, Leilei</creator><creator>Wang, Yin</creator><creator>Li, Peifeng</creator><creator>Song, Jibin</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0003-4771-5006</orcidid></search><sort><creationdate>20230101</creationdate><title>Biomarker‐Responsive Nanosystems for Chronic Disease Theranostics</title><author>Fu, Qinrui ; Yu, Leilei ; Wang, Yin ; Li, Peifeng ; Song, Jibin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3170-7dcee0223329375de636e979f589033d370e747ec5996a147be7bedb1ed120613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Arthritis</topic><topic>Biomarkers</topic><topic>Biomedical materials</topic><topic>chronic diseases</topic><topic>Chronic illnesses</topic><topic>Diabetes mellitus</topic><topic>Diagnosis</topic><topic>Kidney diseases</topic><topic>Materials science</topic><topic>nanomaterials</topic><topic>Neurological diseases</topic><topic>pathological microenvironments</topic><topic>theranostics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fu, Qinrui</creatorcontrib><creatorcontrib>Yu, Leilei</creatorcontrib><creatorcontrib>Wang, Yin</creatorcontrib><creatorcontrib>Li, Peifeng</creatorcontrib><creatorcontrib>Song, Jibin</creatorcontrib><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Advanced functional materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fu, Qinrui</au><au>Yu, Leilei</au><au>Wang, Yin</au><au>Li, Peifeng</au><au>Song, Jibin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomarker‐Responsive Nanosystems for Chronic Disease Theranostics</atitle><jtitle>Advanced functional materials</jtitle><date>2023-01-01</date><risdate>2023</risdate><volume>33</volume><issue>2</issue><epage>n/a</epage><issn>1616-301X</issn><eissn>1616-3028</eissn><abstract>Chronic diseases claim millions of lives every year, and it is of great significance to explore and develop advanced drugs to improve the cure rate of chronic diseases. 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In the following, a variety of intriguing applications of biomarkers‐responsive nanosystems are briefly elaborated, such as biosensing, diagnosis, therapy, combined theranostics, and early evaluation of therapy effect, etc. Finally, the challenges and future directions from research to clinical translation of these responsive nanosystems are also presented.
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| subjects | Arthritis Biomarkers Biomedical materials chronic diseases Chronic illnesses Diabetes mellitus Diagnosis Kidney diseases Materials science nanomaterials Neurological diseases pathological microenvironments theranostics |
| title | Biomarker‐Responsive Nanosystems for Chronic Disease Theranostics |
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