Radon exposure and risk of neurodegenerative diseases among male miners in Ontario, Canada: A cohort study
Background Environmental radon has been examined as a risk factor for neurodegenerative diseases in a small number of previous studies, but the findings have been inconsistent. This study aims to investigate the association between occupational radon exposure and neurodegenerative disease in a cohor...
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| Veröffentlicht in: | American journal of industrial medicine 2023-02, Vol.66 (2), p.132-141 |
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| creator | Zeng, Xiaoke Berriault, Colin Arrandale, Victoria H. DeBono, Nathan L. Harris, M. Anne Demers, Paul A. |
| description | Background
Environmental radon has been examined as a risk factor for neurodegenerative diseases in a small number of previous studies, but the findings have been inconsistent. This study aims to investigate the association between occupational radon exposure and neurodegenerative disease in a cohort of male miners with work experience in multiple ore types in Ontario, Canada.
Methods
Radon exposure (1915–1988) was assessed using two job‐exposure matrices (JEM) constructed from using historical records for 34,536 Ontario male miners. Neurodegenerative outcomes were ascertained between 1992 and 2018. Poisson regression models were used to estimate incidence rate ratios (RR) and 95% confidence intervals (CI) between cumulative radon exposure in working level months (WLM) and each neurodegenerative outcome.
Results
Levels of cumulative radon exposure showed variability among cohort members with a mean of 7.5 WLM (standard deviation 24.4). Miners in uranium mines or underground jobs had higher levels and more variability in exposure than workers in non‐uranium work or surface jobs. Compared to the reference group (radon 1–5 WLM and >5–10 WLM, respectively, but not among higher exposed workers (>10 WLM).
Conclusion
This study did not observe a positive monotonic dose–response relationship between cumulative radon exposure and Alzheimer's or Parkinson's disease in Ontario mining workers. There was no association observed with motor neuron disease. |
| doi_str_mv | 10.1002/ajim.23449 |
| format | Article |
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Environmental radon has been examined as a risk factor for neurodegenerative diseases in a small number of previous studies, but the findings have been inconsistent. This study aims to investigate the association between occupational radon exposure and neurodegenerative disease in a cohort of male miners with work experience in multiple ore types in Ontario, Canada.
Methods
Radon exposure (1915–1988) was assessed using two job‐exposure matrices (JEM) constructed from using historical records for 34,536 Ontario male miners. Neurodegenerative outcomes were ascertained between 1992 and 2018. Poisson regression models were used to estimate incidence rate ratios (RR) and 95% confidence intervals (CI) between cumulative radon exposure in working level months (WLM) and each neurodegenerative outcome.
Results
Levels of cumulative radon exposure showed variability among cohort members with a mean of 7.5 WLM (standard deviation 24.4). Miners in uranium mines or underground jobs had higher levels and more variability in exposure than workers in non‐uranium work or surface jobs. Compared to the reference group (radon < 1 WLM), increased rates of Alzheimer's (RR 1.23, 95% CI 1.05–1.45) and Parkinson's disease (RR 1.43, 95% CI 1.08–1.89) were observed among workers with >1–5 WLM and >5–10 WLM, respectively, but not among higher exposed workers (>10 WLM).
Conclusion
This study did not observe a positive monotonic dose–response relationship between cumulative radon exposure and Alzheimer's or Parkinson's disease in Ontario mining workers. There was no association observed with motor neuron disease.</description><identifier>ISSN: 0271-3586</identifier><identifier>EISSN: 1097-0274</identifier><identifier>DOI: 10.1002/ajim.23449</identifier><identifier>PMID: 36495187</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Alzheimer Disease - complications ; Alzheimer's disease ; brain ; Cohort analysis ; Cohort Studies ; Employment ; Exposure ; Humans ; Lung Neoplasms - epidemiology ; Male ; Males ; metal mining ; Miners ; Motor neuron diseases ; Movement disorders ; Neoplasms, Radiation-Induced ; neurodegeneration ; Neurodegenerative diseases ; Neurodegenerative Diseases - epidemiology ; Neurodegenerative Diseases - etiology ; Occupational Diseases - epidemiology ; Occupational Diseases - etiology ; occupational epidemiology ; Occupational exposure ; Occupational Exposure - adverse effects ; Ontario - epidemiology ; Parkinson Disease ; Parkinson's disease ; Radon ; Radon - adverse effects ; radon daughters ; radon progeny ; Regression analysis ; Regression models ; Risk analysis ; Risk factors ; Statistical analysis ; Underground mines ; Uranium</subject><ispartof>American journal of industrial medicine, 2023-02, Vol.66 (2), p.132-141</ispartof><rights>2022 Wiley Periodicals LLC.</rights><rights>2023 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3579-eb29aadc51ab04b94d9c10818a5c54cffc2247c731502d965f9ba943ceef4b2c3</citedby><cites>FETCH-LOGICAL-c3579-eb29aadc51ab04b94d9c10818a5c54cffc2247c731502d965f9ba943ceef4b2c3</cites><orcidid>0000-0002-9056-4533</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajim.23449$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajim.23449$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36495187$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zeng, Xiaoke</creatorcontrib><creatorcontrib>Berriault, Colin</creatorcontrib><creatorcontrib>Arrandale, Victoria H.</creatorcontrib><creatorcontrib>DeBono, Nathan L.</creatorcontrib><creatorcontrib>Harris, M. Anne</creatorcontrib><creatorcontrib>Demers, Paul A.</creatorcontrib><title>Radon exposure and risk of neurodegenerative diseases among male miners in Ontario, Canada: A cohort study</title><title>American journal of industrial medicine</title><addtitle>Am J Ind Med</addtitle><description>Background
Environmental radon has been examined as a risk factor for neurodegenerative diseases in a small number of previous studies, but the findings have been inconsistent. This study aims to investigate the association between occupational radon exposure and neurodegenerative disease in a cohort of male miners with work experience in multiple ore types in Ontario, Canada.
Methods
Radon exposure (1915–1988) was assessed using two job‐exposure matrices (JEM) constructed from using historical records for 34,536 Ontario male miners. Neurodegenerative outcomes were ascertained between 1992 and 2018. Poisson regression models were used to estimate incidence rate ratios (RR) and 95% confidence intervals (CI) between cumulative radon exposure in working level months (WLM) and each neurodegenerative outcome.
Results
Levels of cumulative radon exposure showed variability among cohort members with a mean of 7.5 WLM (standard deviation 24.4). Miners in uranium mines or underground jobs had higher levels and more variability in exposure than workers in non‐uranium work or surface jobs. Compared to the reference group (radon < 1 WLM), increased rates of Alzheimer's (RR 1.23, 95% CI 1.05–1.45) and Parkinson's disease (RR 1.43, 95% CI 1.08–1.89) were observed among workers with >1–5 WLM and >5–10 WLM, respectively, but not among higher exposed workers (>10 WLM).
Conclusion
This study did not observe a positive monotonic dose–response relationship between cumulative radon exposure and Alzheimer's or Parkinson's disease in Ontario mining workers. There was no association observed with motor neuron disease.</description><subject>Alzheimer Disease - complications</subject><subject>Alzheimer's disease</subject><subject>brain</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Employment</subject><subject>Exposure</subject><subject>Humans</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Male</subject><subject>Males</subject><subject>metal mining</subject><subject>Miners</subject><subject>Motor neuron diseases</subject><subject>Movement disorders</subject><subject>Neoplasms, Radiation-Induced</subject><subject>neurodegeneration</subject><subject>Neurodegenerative diseases</subject><subject>Neurodegenerative Diseases - epidemiology</subject><subject>Neurodegenerative Diseases - etiology</subject><subject>Occupational Diseases - epidemiology</subject><subject>Occupational Diseases - etiology</subject><subject>occupational epidemiology</subject><subject>Occupational exposure</subject><subject>Occupational Exposure - adverse effects</subject><subject>Ontario - epidemiology</subject><subject>Parkinson Disease</subject><subject>Parkinson's disease</subject><subject>Radon</subject><subject>Radon - adverse effects</subject><subject>radon daughters</subject><subject>radon progeny</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Statistical analysis</subject><subject>Underground mines</subject><subject>Uranium</subject><issn>0271-3586</issn><issn>1097-0274</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1u1DAURi1ERaeFDQ-ALLGrmsF27CRmNxr1Z6qiSgjW0Y19Uxwm9mAnpfP2pM2UZVff4h6dKx1CPnK25IyJL9C5filyKfUbsuBMlxkTpXxLFtPwLFdVcUxOUuoY41wW8h05zgupFa_KBem-gw2e4uMupDEiBW9pdOk3DS31OMZg8R49RhjcA1LrEkLCRKEP_p72sEXau-mcqPP0zg8QXTina_Bg4StdURN-hTjQNIx2_54ctbBN-OGwp-Tn5cWP9XV2e3e1Wa9uM5OrUmfYCA1gjeLQMNloabXhrOIVKKOkaVsjhCxNmXPFhNWFanUDWuYGsZWNMPkp-Tx7dzH8GTENdRfG6KeXtSgLUXBeajVRZzNlYkgpYlvvoush7mvO6qes9VPW-jnrBH86KMemR_sffek4AXwG_rot7l9R1aubzbdZ-g8djYNM</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Zeng, Xiaoke</creator><creator>Berriault, Colin</creator><creator>Arrandale, Victoria H.</creator><creator>DeBono, Nathan L.</creator><creator>Harris, M. Anne</creator><creator>Demers, Paul A.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U7</scope><scope>C1K</scope><orcidid>https://orcid.org/0000-0002-9056-4533</orcidid></search><sort><creationdate>202302</creationdate><title>Radon exposure and risk of neurodegenerative diseases among male miners in Ontario, Canada: A cohort study</title><author>Zeng, Xiaoke ; Berriault, Colin ; Arrandale, Victoria H. ; DeBono, Nathan L. ; Harris, M. Anne ; Demers, Paul A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3579-eb29aadc51ab04b94d9c10818a5c54cffc2247c731502d965f9ba943ceef4b2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alzheimer Disease - complications</topic><topic>Alzheimer's disease</topic><topic>brain</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Employment</topic><topic>Exposure</topic><topic>Humans</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Male</topic><topic>Males</topic><topic>metal mining</topic><topic>Miners</topic><topic>Motor neuron diseases</topic><topic>Movement disorders</topic><topic>Neoplasms, Radiation-Induced</topic><topic>neurodegeneration</topic><topic>Neurodegenerative diseases</topic><topic>Neurodegenerative Diseases - epidemiology</topic><topic>Neurodegenerative Diseases - etiology</topic><topic>Occupational Diseases - epidemiology</topic><topic>Occupational Diseases - etiology</topic><topic>occupational epidemiology</topic><topic>Occupational exposure</topic><topic>Occupational Exposure - adverse effects</topic><topic>Ontario - epidemiology</topic><topic>Parkinson Disease</topic><topic>Parkinson's disease</topic><topic>Radon</topic><topic>Radon - adverse effects</topic><topic>radon daughters</topic><topic>radon progeny</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Statistical analysis</topic><topic>Underground mines</topic><topic>Uranium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zeng, Xiaoke</creatorcontrib><creatorcontrib>Berriault, Colin</creatorcontrib><creatorcontrib>Arrandale, Victoria H.</creatorcontrib><creatorcontrib>DeBono, Nathan L.</creatorcontrib><creatorcontrib>Harris, M. Anne</creatorcontrib><creatorcontrib>Demers, Paul A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>American journal of industrial medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeng, Xiaoke</au><au>Berriault, Colin</au><au>Arrandale, Victoria H.</au><au>DeBono, Nathan L.</au><au>Harris, M. Anne</au><au>Demers, Paul A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radon exposure and risk of neurodegenerative diseases among male miners in Ontario, Canada: A cohort study</atitle><jtitle>American journal of industrial medicine</jtitle><addtitle>Am J Ind Med</addtitle><date>2023-02</date><risdate>2023</risdate><volume>66</volume><issue>2</issue><spage>132</spage><epage>141</epage><pages>132-141</pages><issn>0271-3586</issn><eissn>1097-0274</eissn><abstract>Background
Environmental radon has been examined as a risk factor for neurodegenerative diseases in a small number of previous studies, but the findings have been inconsistent. This study aims to investigate the association between occupational radon exposure and neurodegenerative disease in a cohort of male miners with work experience in multiple ore types in Ontario, Canada.
Methods
Radon exposure (1915–1988) was assessed using two job‐exposure matrices (JEM) constructed from using historical records for 34,536 Ontario male miners. Neurodegenerative outcomes were ascertained between 1992 and 2018. Poisson regression models were used to estimate incidence rate ratios (RR) and 95% confidence intervals (CI) between cumulative radon exposure in working level months (WLM) and each neurodegenerative outcome.
Results
Levels of cumulative radon exposure showed variability among cohort members with a mean of 7.5 WLM (standard deviation 24.4). Miners in uranium mines or underground jobs had higher levels and more variability in exposure than workers in non‐uranium work or surface jobs. Compared to the reference group (radon < 1 WLM), increased rates of Alzheimer's (RR 1.23, 95% CI 1.05–1.45) and Parkinson's disease (RR 1.43, 95% CI 1.08–1.89) were observed among workers with >1–5 WLM and >5–10 WLM, respectively, but not among higher exposed workers (>10 WLM).
Conclusion
This study did not observe a positive monotonic dose–response relationship between cumulative radon exposure and Alzheimer's or Parkinson's disease in Ontario mining workers. There was no association observed with motor neuron disease.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36495187</pmid><doi>10.1002/ajim.23449</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9056-4533</orcidid></addata></record> |
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| ispartof | American journal of industrial medicine, 2023-02, Vol.66 (2), p.132-141 |
| issn | 0271-3586 1097-0274 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Alzheimer Disease - complications Alzheimer's disease brain Cohort analysis Cohort Studies Employment Exposure Humans Lung Neoplasms - epidemiology Male Males metal mining Miners Motor neuron diseases Movement disorders Neoplasms, Radiation-Induced neurodegeneration Neurodegenerative diseases Neurodegenerative Diseases - epidemiology Neurodegenerative Diseases - etiology Occupational Diseases - epidemiology Occupational Diseases - etiology occupational epidemiology Occupational exposure Occupational Exposure - adverse effects Ontario - epidemiology Parkinson Disease Parkinson's disease Radon Radon - adverse effects radon daughters radon progeny Regression analysis Regression models Risk analysis Risk factors Statistical analysis Underground mines Uranium |
| title | Radon exposure and risk of neurodegenerative diseases among male miners in Ontario, Canada: A cohort study |
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