Development of recombinant adenovirus vector herpes zoster vaccine production process using perfusion strategy with tangential flow filtration system

BACKGROUND Herpes zoster (HZ) causes painful skin and nerve lesions, and its most frequent complication is postherpetic neuralgia. Currently, vaccination is recommended to decrease the incidence of HZ, and cost‐effective vaccine production strategies are required to produce low‐cost vaccines. Perfus...

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Veröffentlicht in:	Journal of chemical technology and biotechnology (1986) 2023-02, Vol.98 (2), p.526-536
Hauptverfasser:	Sun, Yang, Feng, Kai, Nie, Jianqi, Huang, Lingling, Liu, Yupeng, Bai, Zhonghu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Bioreactors Cell culture Cell density Cultivation Design of experiments Design optimization Filtration Flasks Glutamine Herpes zoster herpes zoster vaccine Mammalian cells Multiplicity of infection Neuralgia Nutrition Parameter robustness Perfusion perfusion cultivation process optimization Process parameters recombinant adenovirus vector Robustness Skin diseases TFF system Vaccines Viruses
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