Acetaminophen-Induced Nephrotoxicity: Suppression of Apoptosis and Endoplasmic Reticulum Stress Using Boric Acid

Acetaminophen (APAP) is one of the popular and safe pain medications worldwide. However, due its wide availability, it is frequently implicated in intentional or unintentional overdoses where it can cause severe liver injury and even acute liver failure. Boron is a bioactive trace element, found nat...

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Veröffentlicht in:	Biological trace element research 2023-01, Vol.201 (1), p.242-249
Hauptverfasser:	Çoban, Funda Karabağ, İnce, Sinan, Demirel, Hasan Hüseyin, İslam, İzzet, Aytuğ, Hande
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - metabolism Acetaminophen - toxicity Acetylcysteine Acetylcysteine - pharmacology Acids Analgesics Animals Apoptosis Bcl-2 protein Bcl-x protein Biochemistry Biocompatibility Biomedical and Life Sciences Biotechnology Boric acid Boron Boron - pharmacology Carboxymethyl cellulose Cellulose Creatine Cysteine Damage Endoplasmic reticulum Endoplasmic Reticulum Stress Gene expression Interleukin 18 Kidney Diseases - chemically induced Kidneys Life Sciences Liver Liver diseases Methylcellulose NF-κB protein Nitric-oxide synthase Nutrition Oncology Overdose p53 Protein Paracetamol Phosphates Prophylaxis Rats Toxicity Trace elements Variance analysis
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