A surface acoustic wave-assisted micromixer with active temperature control
Microfluidic mixing is a critical issue in the lab-on-a-chip system, which has been applied in various biomedical research. Recently, acoustic wave-based active micromixers have been applied to increase the mixing efficiency via acoustic streaming. However, along with the acoustic streaming, the aco...
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| Veröffentlicht in: | Sensors and actuators. A. Physical. 2022-10, Vol.346, p.113833, Article 113833 |
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| container_title | Sensors and actuators. A. Physical. |
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| creator | Bai, Cheng Zhou, Wen Yu, Shifeng Zheng, Tengfei Wang, Chaohui |
| description | Microfluidic mixing is a critical issue in the lab-on-a-chip system, which has been applied in various biomedical research. Recently, acoustic wave-based active micromixers have been applied to increase the mixing efficiency via acoustic streaming. However, along with the acoustic streaming, the acoustic thermal effect will generate additional heat to increase the temperature of the microfluid. In this work, we present an integrated thermal control unit applied to a surface acoustic wave (SAW)-assisted micromixer to address this problem. A metal microwire as the thermal resistance sensor is fabricated under the microchannel to measure the temperature in different conditions, together with the Peltier cooler beneath allowing the active temperature control of the microfluid. For characterization, neutralization reaction and alkaline phosphatase assay were successfully conducted on this device. It shows the integrated thermal control unit applied to a SAW-assisted micromixer is highly effective in temperature-sensitive biomedical research.
[Display omitted]
•A novel SAW-assisted micromixer was developed to control the fluid temperature.•The thermal effect of SAW has been investigated through the temperature sensor.•Neutralization reaction and ALP assay were successfully conducted on this device. |
| doi_str_mv | 10.1016/j.sna.2022.113833 |
| format | Article |
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[Display omitted]
•A novel SAW-assisted micromixer was developed to control the fluid temperature.•The thermal effect of SAW has been investigated through the temperature sensor.•Neutralization reaction and ALP assay were successfully conducted on this device.</description><identifier>ISSN: 0924-4247</identifier><identifier>EISSN: 1873-3069</identifier><identifier>DOI: 10.1016/j.sna.2022.113833</identifier><language>eng</language><publisher>Lausanne: Elsevier B.V</publisher><subject>Acoustic streaming ; Active control ; Alkaline phosphatase ; Control ; Enzymatic reaction ; Microchannels ; Microfluidics ; Micromixer ; Sensors ; Surface acoustic waves ; Temperature control ; Temperature effects ; Thermal resistance</subject><ispartof>Sensors and actuators. A. Physical., 2022-10, Vol.346, p.113833, Article 113833</ispartof><rights>2022 Elsevier B.V.</rights><rights>Copyright Elsevier BV Oct 16, 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c325t-6e588916609984dea6839f9f06e9c7653b0a5252bdc2013304f309ce6c1e915f3</citedby><cites>FETCH-LOGICAL-c325t-6e588916609984dea6839f9f06e9c7653b0a5252bdc2013304f309ce6c1e915f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.sna.2022.113833$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Bai, Cheng</creatorcontrib><creatorcontrib>Zhou, Wen</creatorcontrib><creatorcontrib>Yu, Shifeng</creatorcontrib><creatorcontrib>Zheng, Tengfei</creatorcontrib><creatorcontrib>Wang, Chaohui</creatorcontrib><title>A surface acoustic wave-assisted micromixer with active temperature control</title><title>Sensors and actuators. A. Physical.</title><description>Microfluidic mixing is a critical issue in the lab-on-a-chip system, which has been applied in various biomedical research. Recently, acoustic wave-based active micromixers have been applied to increase the mixing efficiency via acoustic streaming. However, along with the acoustic streaming, the acoustic thermal effect will generate additional heat to increase the temperature of the microfluid. In this work, we present an integrated thermal control unit applied to a surface acoustic wave (SAW)-assisted micromixer to address this problem. A metal microwire as the thermal resistance sensor is fabricated under the microchannel to measure the temperature in different conditions, together with the Peltier cooler beneath allowing the active temperature control of the microfluid. For characterization, neutralization reaction and alkaline phosphatase assay were successfully conducted on this device. It shows the integrated thermal control unit applied to a SAW-assisted micromixer is highly effective in temperature-sensitive biomedical research.
[Display omitted]
•A novel SAW-assisted micromixer was developed to control the fluid temperature.•The thermal effect of SAW has been investigated through the temperature sensor.•Neutralization reaction and ALP assay were successfully conducted on this device.</description><subject>Acoustic streaming</subject><subject>Active control</subject><subject>Alkaline phosphatase</subject><subject>Control</subject><subject>Enzymatic reaction</subject><subject>Microchannels</subject><subject>Microfluidics</subject><subject>Micromixer</subject><subject>Sensors</subject><subject>Surface acoustic waves</subject><subject>Temperature control</subject><subject>Temperature effects</subject><subject>Thermal resistance</subject><issn>0924-4247</issn><issn>1873-3069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0EEuXxAewisU4Y27ETi1VV8RKV2MDacp2JcNQkxXZa-HtchTWr2Zx75-oQckOhoEDlXVeEwRQMGCso5TXnJ2RB64rnHKQ6JQtQrMxLVlbn5CKEDgA4r6oFeV1mYfKtsZgZO04hOpsdzB5zE4ILEZusd9aPvftGnx1c_ExYdHvMIvY79CZOHjM7DtGP2yty1pptwOu_e0k-Hh_eV8_5-u3pZbVc55YzEXOJoq4VlRKUqssGjay5alULEpWtpOAbMIIJtmksA8o5lC0HZVFaioqKll-S27l358evCUPU3Tj5Ib3UrJJJgVBCJIrOVJofgsdW77zrjf_RFPTRme50cqaPzvTsLGXu5wym-XuHXgfrcLDYOI826mZ0_6R_AbUHc7I</recordid><startdate>20221016</startdate><enddate>20221016</enddate><creator>Bai, Cheng</creator><creator>Zhou, Wen</creator><creator>Yu, Shifeng</creator><creator>Zheng, Tengfei</creator><creator>Wang, Chaohui</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7TB</scope><scope>7U5</scope><scope>8FD</scope><scope>FR3</scope><scope>L7M</scope></search><sort><creationdate>20221016</creationdate><title>A surface acoustic wave-assisted micromixer with active temperature control</title><author>Bai, Cheng ; Zhou, Wen ; Yu, Shifeng ; Zheng, Tengfei ; Wang, Chaohui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c325t-6e588916609984dea6839f9f06e9c7653b0a5252bdc2013304f309ce6c1e915f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acoustic streaming</topic><topic>Active control</topic><topic>Alkaline phosphatase</topic><topic>Control</topic><topic>Enzymatic reaction</topic><topic>Microchannels</topic><topic>Microfluidics</topic><topic>Micromixer</topic><topic>Sensors</topic><topic>Surface acoustic waves</topic><topic>Temperature control</topic><topic>Temperature effects</topic><topic>Thermal resistance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bai, Cheng</creatorcontrib><creatorcontrib>Zhou, Wen</creatorcontrib><creatorcontrib>Yu, Shifeng</creatorcontrib><creatorcontrib>Zheng, Tengfei</creatorcontrib><creatorcontrib>Wang, Chaohui</creatorcontrib><collection>CrossRef</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Sensors and actuators. A. Physical.</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bai, Cheng</au><au>Zhou, Wen</au><au>Yu, Shifeng</au><au>Zheng, Tengfei</au><au>Wang, Chaohui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A surface acoustic wave-assisted micromixer with active temperature control</atitle><jtitle>Sensors and actuators. A. Physical.</jtitle><date>2022-10-16</date><risdate>2022</risdate><volume>346</volume><spage>113833</spage><pages>113833-</pages><artnum>113833</artnum><issn>0924-4247</issn><eissn>1873-3069</eissn><abstract>Microfluidic mixing is a critical issue in the lab-on-a-chip system, which has been applied in various biomedical research. Recently, acoustic wave-based active micromixers have been applied to increase the mixing efficiency via acoustic streaming. However, along with the acoustic streaming, the acoustic thermal effect will generate additional heat to increase the temperature of the microfluid. In this work, we present an integrated thermal control unit applied to a surface acoustic wave (SAW)-assisted micromixer to address this problem. A metal microwire as the thermal resistance sensor is fabricated under the microchannel to measure the temperature in different conditions, together with the Peltier cooler beneath allowing the active temperature control of the microfluid. For characterization, neutralization reaction and alkaline phosphatase assay were successfully conducted on this device. It shows the integrated thermal control unit applied to a SAW-assisted micromixer is highly effective in temperature-sensitive biomedical research.
[Display omitted]
•A novel SAW-assisted micromixer was developed to control the fluid temperature.•The thermal effect of SAW has been investigated through the temperature sensor.•Neutralization reaction and ALP assay were successfully conducted on this device.</abstract><cop>Lausanne</cop><pub>Elsevier B.V</pub><doi>10.1016/j.sna.2022.113833</doi></addata></record> |
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| ispartof | Sensors and actuators. A. Physical., 2022-10, Vol.346, p.113833, Article 113833 |
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| language | eng |
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| source | Access via ScienceDirect (Elsevier) |
| subjects | Acoustic streaming Active control Alkaline phosphatase Control Enzymatic reaction Microchannels Microfluidics Micromixer Sensors Surface acoustic waves Temperature control Temperature effects Thermal resistance |
| title | A surface acoustic wave-assisted micromixer with active temperature control |
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