Transient hypogammaglobulinaemia of the young in a Thoroughbred yearling
Summary A 12‐month‐old Thoroughbred colt was presented for chronic recurrent respiratory disease characterised by persistent nasal discharge, intermittent pyrexia and coughing of several months' duration. These episodes were responsive to empirical antimicrobial therapy but returned once therap...
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| Veröffentlicht in: | Equine veterinary education 2023-02, Vol.35 (2), p.e86-e90 |
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| container_title | Equine veterinary education |
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| creator | Cock, Gemma Felippe, M. Julia B. Blair, Armon DeNotta, Sally |
| description | Summary
A 12‐month‐old Thoroughbred colt was presented for chronic recurrent respiratory disease characterised by persistent nasal discharge, intermittent pyrexia and coughing of several months' duration. These episodes were responsive to empirical antimicrobial therapy but returned once therapy was discontinued. History, physical examination and initial diagnostics were suggestive of bacterial pneumonia and possible underlying immunodeficiency. Serum immunoglobulin analysis and peripheral blood lymphocyte phenotyping revealed low serum IgG and IgM concentrations. In this 12‐month‐old colt, low serum IgG concentration was the most diagnostic parameter and supported a presumptive diagnosis of transient hypogammaglobulinaemia of the young. The colt responded favourably to repeated treatment with antimicrobials for bacterial pneumonia, and serial immunologic testing over the following months showed gradual increase in serum IgG and IgM concentrations, supporting the diagnosis of delayed development of humoral immunity in this patient. |
| doi_str_mv | 10.1111/eve.13624 |
| format | Article |
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A 12‐month‐old Thoroughbred colt was presented for chronic recurrent respiratory disease characterised by persistent nasal discharge, intermittent pyrexia and coughing of several months' duration. These episodes were responsive to empirical antimicrobial therapy but returned once therapy was discontinued. History, physical examination and initial diagnostics were suggestive of bacterial pneumonia and possible underlying immunodeficiency. Serum immunoglobulin analysis and peripheral blood lymphocyte phenotyping revealed low serum IgG and IgM concentrations. In this 12‐month‐old colt, low serum IgG concentration was the most diagnostic parameter and supported a presumptive diagnosis of transient hypogammaglobulinaemia of the young. The colt responded favourably to repeated treatment with antimicrobials for bacterial pneumonia, and serial immunologic testing over the following months showed gradual increase in serum IgG and IgM concentrations, supporting the diagnosis of delayed development of humoral immunity in this patient.</description><identifier>ISSN: 0957-7734</identifier><identifier>EISSN: 2042-3292</identifier><identifier>DOI: 10.1111/eve.13624</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>Antiinfectives and antibacterials ; Antimicrobial agents ; Diagnosis ; diagnostic ; Empirical analysis ; equine immunology ; Fever ; horse ; Humoral immunity ; Immunodeficiency ; Immunoglobulin G ; Immunoglobulin M ; Lymphocytes ; Peripheral blood ; Phenotyping ; Pneumonia ; Respiratory diseases</subject><ispartof>Equine veterinary education, 2023-02, Vol.35 (2), p.e86-e90</ispartof><rights>2022 EVJ Ltd</rights><rights>Copyright © 2023 EVJ Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2974-3444345ce34673c31594d35340aaf2ddb7c2a43b9b3fab35c98e555869bf75d93</citedby><cites>FETCH-LOGICAL-c2974-3444345ce34673c31594d35340aaf2ddb7c2a43b9b3fab35c98e555869bf75d93</cites><orcidid>0000-0002-2186-2422</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Feve.13624$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Feve.13624$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Cock, Gemma</creatorcontrib><creatorcontrib>Felippe, M. Julia B.</creatorcontrib><creatorcontrib>Blair, Armon</creatorcontrib><creatorcontrib>DeNotta, Sally</creatorcontrib><title>Transient hypogammaglobulinaemia of the young in a Thoroughbred yearling</title><title>Equine veterinary education</title><description>Summary
A 12‐month‐old Thoroughbred colt was presented for chronic recurrent respiratory disease characterised by persistent nasal discharge, intermittent pyrexia and coughing of several months' duration. These episodes were responsive to empirical antimicrobial therapy but returned once therapy was discontinued. History, physical examination and initial diagnostics were suggestive of bacterial pneumonia and possible underlying immunodeficiency. Serum immunoglobulin analysis and peripheral blood lymphocyte phenotyping revealed low serum IgG and IgM concentrations. In this 12‐month‐old colt, low serum IgG concentration was the most diagnostic parameter and supported a presumptive diagnosis of transient hypogammaglobulinaemia of the young. The colt responded favourably to repeated treatment with antimicrobials for bacterial pneumonia, and serial immunologic testing over the following months showed gradual increase in serum IgG and IgM concentrations, supporting the diagnosis of delayed development of humoral immunity in this patient.</description><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial agents</subject><subject>Diagnosis</subject><subject>diagnostic</subject><subject>Empirical analysis</subject><subject>equine immunology</subject><subject>Fever</subject><subject>horse</subject><subject>Humoral immunity</subject><subject>Immunodeficiency</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin M</subject><subject>Lymphocytes</subject><subject>Peripheral blood</subject><subject>Phenotyping</subject><subject>Pneumonia</subject><subject>Respiratory diseases</subject><issn>0957-7734</issn><issn>2042-3292</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp10D1PwzAQBmALgUQpDPwDS0wMaR2fHccjqkKLVImlsFp24nxUSVzsBpR_TyCs3HLL895JL0L3MVnF06ztp13FkFB2gRaUMBoBlfQSLYjkIhIC2DW6CeFICGeCigXaHbzuQ2P7M67Hk6t01-mqdWZom17brtHYlfhcWzy6oa9w02OND7Xzbqhq422BR6v9ZKtbdFXqNti7v71Eb8_ZYbOL9q_bl83TPsqpFCwCxhgwnltgiYAcYi5ZARwY0bqkRWFETjUDIw2U2gDPZWo552kiTSl4IWGJHua7J-8-BhvO6ugG308vFRUJIUmapOmkHmeVexeCt6U6-abTflQxUT9Fqako9VvUZNez_WpaO_4PVfaezYlvsn5pog</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Cock, Gemma</creator><creator>Felippe, M. Julia B.</creator><creator>Blair, Armon</creator><creator>DeNotta, Sally</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><orcidid>https://orcid.org/0000-0002-2186-2422</orcidid></search><sort><creationdate>202302</creationdate><title>Transient hypogammaglobulinaemia of the young in a Thoroughbred yearling</title><author>Cock, Gemma ; Felippe, M. Julia B. ; Blair, Armon ; DeNotta, Sally</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2974-3444345ce34673c31594d35340aaf2ddb7c2a43b9b3fab35c98e555869bf75d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial agents</topic><topic>Diagnosis</topic><topic>diagnostic</topic><topic>Empirical analysis</topic><topic>equine immunology</topic><topic>Fever</topic><topic>horse</topic><topic>Humoral immunity</topic><topic>Immunodeficiency</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin M</topic><topic>Lymphocytes</topic><topic>Peripheral blood</topic><topic>Phenotyping</topic><topic>Pneumonia</topic><topic>Respiratory diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cock, Gemma</creatorcontrib><creatorcontrib>Felippe, M. Julia B.</creatorcontrib><creatorcontrib>Blair, Armon</creatorcontrib><creatorcontrib>DeNotta, Sally</creatorcontrib><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><jtitle>Equine veterinary education</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cock, Gemma</au><au>Felippe, M. Julia B.</au><au>Blair, Armon</au><au>DeNotta, Sally</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transient hypogammaglobulinaemia of the young in a Thoroughbred yearling</atitle><jtitle>Equine veterinary education</jtitle><date>2023-02</date><risdate>2023</risdate><volume>35</volume><issue>2</issue><spage>e86</spage><epage>e90</epage><pages>e86-e90</pages><issn>0957-7734</issn><eissn>2042-3292</eissn><abstract>Summary
A 12‐month‐old Thoroughbred colt was presented for chronic recurrent respiratory disease characterised by persistent nasal discharge, intermittent pyrexia and coughing of several months' duration. These episodes were responsive to empirical antimicrobial therapy but returned once therapy was discontinued. History, physical examination and initial diagnostics were suggestive of bacterial pneumonia and possible underlying immunodeficiency. Serum immunoglobulin analysis and peripheral blood lymphocyte phenotyping revealed low serum IgG and IgM concentrations. In this 12‐month‐old colt, low serum IgG concentration was the most diagnostic parameter and supported a presumptive diagnosis of transient hypogammaglobulinaemia of the young. The colt responded favourably to repeated treatment with antimicrobials for bacterial pneumonia, and serial immunologic testing over the following months showed gradual increase in serum IgG and IgM concentrations, supporting the diagnosis of delayed development of humoral immunity in this patient.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/eve.13624</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-2186-2422</orcidid></addata></record> |
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| ispartof | Equine veterinary education, 2023-02, Vol.35 (2), p.e86-e90 |
| issn | 0957-7734 2042-3292 |
| language | eng |
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| source | Wiley Journals |
| subjects | Antiinfectives and antibacterials Antimicrobial agents Diagnosis diagnostic Empirical analysis equine immunology Fever horse Humoral immunity Immunodeficiency Immunoglobulin G Immunoglobulin M Lymphocytes Peripheral blood Phenotyping Pneumonia Respiratory diseases |
| title | Transient hypogammaglobulinaemia of the young in a Thoroughbred yearling |
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