Chitosan based hybrid hydrogels for drug delivery: Preparation, biodegradation, thermal, and mechanical properties
In the present paper, biodegradable hybrid hydrogels were prepared by using chitosan as a natural polymer and polyurethane containing azomethine as a synthetic polymer for the drug delivery application for 5‐fluorouracil. The fabricated hydrogels were characterized via FT‐IR and SEM analysis. Beside...
Gespeichert in:
| Veröffentlicht in: | Polymers for advanced technologies 2023-02, Vol.34 (2), p.779-788 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 788 |
|---|---|
| container_issue | 2 |
| container_start_page | 779 |
| container_title | Polymers for advanced technologies |
| container_volume | 34 |
| creator | Kamaci, Musa Kaya, Ismet |
| description | In the present paper, biodegradable hybrid hydrogels were prepared by using chitosan as a natural polymer and polyurethane containing azomethine as a synthetic polymer for the drug delivery application for 5‐fluorouracil. The fabricated hydrogels were characterized via FT‐IR and SEM analysis. Besides, the thermal, mechanical, and wettability properties, water uptake, biodegradation, protein absorption, drug loading, and release behaviors of the hybrid hydrogels were studied. The obtained results indicated that the fabricated hybrid hydrogels have exhibited good mechanical, hydrophilic, water uptake, and biodegradation behaviors. The hybrid hydrogels also showed 50% drug release amounts and they could be a good candidate for the controlled delivery of 5‐FU due to these properties. |
| doi_str_mv | 10.1002/pat.5930 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2760016017</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2760016017</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2230-11896123c76575c9ece173320d71abbc9707bc11a8f7a2ffeae9be014f22bad83</originalsourceid><addsrcrecordid>eNp1kE9Lw0AQxRdRsFbBj7DgxYOpu5smm3grxX9QsId6DpPdSbMlTeJsquTbm9hePb0Z3o_34DF2K8VMCqEeW-hmURqKMzaRIk0DGSXyfLznKtByri_Zlfc7IQYv1RNGy9J1jYea5-DR8rLPyY1iqdli5XnRELd02HKLlftG6p_4mrAFgs419QPPXWNxS2BPf1ci7aF64FBbvkdTQu0MVLylpkXqHPprdlFA5fHmpFP2-fK8Wb4Fq4_X9-ViFRilQhFImaSxVKHRcaQjk6JBqcNQCasl5LlJtdC5kRKSQoMqCgRMcxRyXiiVg03CKbs75g7VXwf0XbZrDlQPlZnSsRAyFkPglN0fKUON94RF1pLbA_WZFNm4aDYsmo2LDmhwRH9chf2_XLZebP74XwLHeOM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2760016017</pqid></control><display><type>article</type><title>Chitosan based hybrid hydrogels for drug delivery: Preparation, biodegradation, thermal, and mechanical properties</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kamaci, Musa ; Kaya, Ismet</creator><creatorcontrib>Kamaci, Musa ; Kaya, Ismet</creatorcontrib><description>In the present paper, biodegradable hybrid hydrogels were prepared by using chitosan as a natural polymer and polyurethane containing azomethine as a synthetic polymer for the drug delivery application for 5‐fluorouracil. The fabricated hydrogels were characterized via FT‐IR and SEM analysis. Besides, the thermal, mechanical, and wettability properties, water uptake, biodegradation, protein absorption, drug loading, and release behaviors of the hybrid hydrogels were studied. The obtained results indicated that the fabricated hybrid hydrogels have exhibited good mechanical, hydrophilic, water uptake, and biodegradation behaviors. The hybrid hydrogels also showed 50% drug release amounts and they could be a good candidate for the controlled delivery of 5‐FU due to these properties.</description><identifier>ISSN: 1042-7147</identifier><identifier>EISSN: 1099-1581</identifier><identifier>DOI: 10.1002/pat.5930</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Biodegradability ; Biodegradation ; Chitosan ; drug delivery ; hybrid hydrogel ; Hydrogels ; Mechanical properties ; Natural polymers ; polyurethane ; Polyurethane resins ; Wettability</subject><ispartof>Polymers for advanced technologies, 2023-02, Vol.34 (2), p.779-788</ispartof><rights>2022 John Wiley & Sons Ltd.</rights><rights>2023 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2230-11896123c76575c9ece173320d71abbc9707bc11a8f7a2ffeae9be014f22bad83</citedby><cites>FETCH-LOGICAL-c2230-11896123c76575c9ece173320d71abbc9707bc11a8f7a2ffeae9be014f22bad83</cites><orcidid>0000-0002-9813-2962 ; 0000-0001-5865-7687</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpat.5930$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpat.5930$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Kamaci, Musa</creatorcontrib><creatorcontrib>Kaya, Ismet</creatorcontrib><title>Chitosan based hybrid hydrogels for drug delivery: Preparation, biodegradation, thermal, and mechanical properties</title><title>Polymers for advanced technologies</title><description>In the present paper, biodegradable hybrid hydrogels were prepared by using chitosan as a natural polymer and polyurethane containing azomethine as a synthetic polymer for the drug delivery application for 5‐fluorouracil. The fabricated hydrogels were characterized via FT‐IR and SEM analysis. Besides, the thermal, mechanical, and wettability properties, water uptake, biodegradation, protein absorption, drug loading, and release behaviors of the hybrid hydrogels were studied. The obtained results indicated that the fabricated hybrid hydrogels have exhibited good mechanical, hydrophilic, water uptake, and biodegradation behaviors. The hybrid hydrogels also showed 50% drug release amounts and they could be a good candidate for the controlled delivery of 5‐FU due to these properties.</description><subject>Biodegradability</subject><subject>Biodegradation</subject><subject>Chitosan</subject><subject>drug delivery</subject><subject>hybrid hydrogel</subject><subject>Hydrogels</subject><subject>Mechanical properties</subject><subject>Natural polymers</subject><subject>polyurethane</subject><subject>Polyurethane resins</subject><subject>Wettability</subject><issn>1042-7147</issn><issn>1099-1581</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kE9Lw0AQxRdRsFbBj7DgxYOpu5smm3grxX9QsId6DpPdSbMlTeJsquTbm9hePb0Z3o_34DF2K8VMCqEeW-hmURqKMzaRIk0DGSXyfLznKtByri_Zlfc7IQYv1RNGy9J1jYea5-DR8rLPyY1iqdli5XnRELd02HKLlftG6p_4mrAFgs419QPPXWNxS2BPf1ci7aF64FBbvkdTQu0MVLylpkXqHPprdlFA5fHmpFP2-fK8Wb4Fq4_X9-ViFRilQhFImaSxVKHRcaQjk6JBqcNQCasl5LlJtdC5kRKSQoMqCgRMcxRyXiiVg03CKbs75g7VXwf0XbZrDlQPlZnSsRAyFkPglN0fKUON94RF1pLbA_WZFNm4aDYsmo2LDmhwRH9chf2_XLZebP74XwLHeOM</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Kamaci, Musa</creator><creator>Kaya, Ismet</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0002-9813-2962</orcidid><orcidid>https://orcid.org/0000-0001-5865-7687</orcidid></search><sort><creationdate>202302</creationdate><title>Chitosan based hybrid hydrogels for drug delivery: Preparation, biodegradation, thermal, and mechanical properties</title><author>Kamaci, Musa ; Kaya, Ismet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2230-11896123c76575c9ece173320d71abbc9707bc11a8f7a2ffeae9be014f22bad83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biodegradability</topic><topic>Biodegradation</topic><topic>Chitosan</topic><topic>drug delivery</topic><topic>hybrid hydrogel</topic><topic>Hydrogels</topic><topic>Mechanical properties</topic><topic>Natural polymers</topic><topic>polyurethane</topic><topic>Polyurethane resins</topic><topic>Wettability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamaci, Musa</creatorcontrib><creatorcontrib>Kaya, Ismet</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Polymers for advanced technologies</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamaci, Musa</au><au>Kaya, Ismet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chitosan based hybrid hydrogels for drug delivery: Preparation, biodegradation, thermal, and mechanical properties</atitle><jtitle>Polymers for advanced technologies</jtitle><date>2023-02</date><risdate>2023</risdate><volume>34</volume><issue>2</issue><spage>779</spage><epage>788</epage><pages>779-788</pages><issn>1042-7147</issn><eissn>1099-1581</eissn><abstract>In the present paper, biodegradable hybrid hydrogels were prepared by using chitosan as a natural polymer and polyurethane containing azomethine as a synthetic polymer for the drug delivery application for 5‐fluorouracil. The fabricated hydrogels were characterized via FT‐IR and SEM analysis. Besides, the thermal, mechanical, and wettability properties, water uptake, biodegradation, protein absorption, drug loading, and release behaviors of the hybrid hydrogels were studied. The obtained results indicated that the fabricated hybrid hydrogels have exhibited good mechanical, hydrophilic, water uptake, and biodegradation behaviors. The hybrid hydrogels also showed 50% drug release amounts and they could be a good candidate for the controlled delivery of 5‐FU due to these properties.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/pat.5930</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9813-2962</orcidid><orcidid>https://orcid.org/0000-0001-5865-7687</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1042-7147 |
| ispartof | Polymers for advanced technologies, 2023-02, Vol.34 (2), p.779-788 |
| issn | 1042-7147 1099-1581 |
| language | eng |
| recordid | cdi_proquest_journals_2760016017 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Biodegradability Biodegradation Chitosan drug delivery hybrid hydrogel Hydrogels Mechanical properties Natural polymers polyurethane Polyurethane resins Wettability |
| title | Chitosan based hybrid hydrogels for drug delivery: Preparation, biodegradation, thermal, and mechanical properties |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T05%3A03%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chitosan%20based%20hybrid%20hydrogels%20for%20drug%20delivery:%20Preparation,%20biodegradation,%20thermal,%20and%20mechanical%20properties&rft.jtitle=Polymers%20for%20advanced%20technologies&rft.au=Kamaci,%20Musa&rft.date=2023-02&rft.volume=34&rft.issue=2&rft.spage=779&rft.epage=788&rft.pages=779-788&rft.issn=1042-7147&rft.eissn=1099-1581&rft_id=info:doi/10.1002/pat.5930&rft_dat=%3Cproquest_cross%3E2760016017%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2760016017&rft_id=info:pmid/&rfr_iscdi=true |