Development of squamous cell carcinoma in the setting of chronic discoid lupus erythematosus may be associated with plasmacytoid dendritic cell inflammation
Discoid lupus erythematosus (DLE) is the most common type of cutaneous lupus and is clinically characterized by alopecia, depigmentation, and scars on sun‐exposed skin. Squamous cell carcinoma is a potential long‐term complication. The most important risk factor for squamous cell carcinoma developme...
Gespeichert in:
| Veröffentlicht in: | Journal of cutaneous pathology 2023-01, Vol.50 (1), p.19-23 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 23 |
|---|---|
| container_issue | 1 |
| container_start_page | 19 |
| container_title | Journal of cutaneous pathology |
| container_volume | 50 |
| creator | Ju, Teresa Ingrasci, Giuseppe Diaz‐Perez, Julio A. Obayomi, Aderonke Yosipovitch, Gil |
| description | Discoid lupus erythematosus (DLE) is the most common type of cutaneous lupus and is clinically characterized by alopecia, depigmentation, and scars on sun‐exposed skin. Squamous cell carcinoma is a potential long‐term complication. The most important risk factor for squamous cell carcinoma development in people with dark skin is chronic scarring and inflammation, such as those seen in long‐standing discoid plaques. African Americans who develop squamous cell carcinoma in the setting of chronic scarring and inflammation have a greater risk of metastasis and recurrence compared to sun‐induced squamous cell carcinoma seen in whites. Despite this, the pathogenesis of squamous cell carcinoma development in chronic DLE is not fully understood. Herein, we describe a case of an African American patient who developed squamous cell carcinoma on a long‐standing discoid plaque. Analysis of the lesion revealed a null type pattern of p53 protein expression and abundant CD123+ plasmacytoid dendritic cells, as potential drivers of oncogenesis and inflammation, respectively. Dermatologists should be aware of the increased risk of squamous cell carcinoma development within long‐standing discoid plaques for a prompt early diagnosis and active long‐term surveillance. |
| doi_str_mv | 10.1111/cup.14304 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2759016066</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2759016066</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2504-e7018340421681397d89ffad0eefdd1b03eda63d51aa840453c96a817f6494013</originalsourceid><addsrcrecordid>eNp1kcFO3DAQhq2KCrbAoS9QWeLUQ2AcJ05yrLaFIiHRA5wjrz3pGsV2sJ2ivAsPi5el3JiLNdI338jzE_KVwTnLdaHm6ZxVHKpPZMUEQAG1gAOyAg68EF3bHJEvMT4AMNGK-pAc8borS96wFXn-if9w9JNFl6gfaHycpfVzpArHkSoZlHHeSmocTVukEVMy7u-OVNvgnVFUm6i80XScpzyGYcmclcnH3Fm50A1SGaNXRibU9MmkLZ1GGa1US9rNaXQ6mJRNryuNG0Zps8B4d0I-D3KMePr2HpP7y19369_Fze3V9frHTaHKGqoCG2Atr6Aq8_8Y7xrddsMgNSAOWrMNcNRScF0zKduM1Vx1QrasGUTVVcD4MTnbe6fgH2eMqX_wc3B5ZV82dZfPBkJk6vueUsHHGHDop2CsDEvPoN_l0Occ-tccMvvtzThvLOp38v_hM3CxB57MiMvHpn59_2evfAHE8pUA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2759016066</pqid></control><display><type>article</type><title>Development of squamous cell carcinoma in the setting of chronic discoid lupus erythematosus may be associated with plasmacytoid dendritic cell inflammation</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Ju, Teresa ; Ingrasci, Giuseppe ; Diaz‐Perez, Julio A. ; Obayomi, Aderonke ; Yosipovitch, Gil</creator><creatorcontrib>Ju, Teresa ; Ingrasci, Giuseppe ; Diaz‐Perez, Julio A. ; Obayomi, Aderonke ; Yosipovitch, Gil</creatorcontrib><description>Discoid lupus erythematosus (DLE) is the most common type of cutaneous lupus and is clinically characterized by alopecia, depigmentation, and scars on sun‐exposed skin. Squamous cell carcinoma is a potential long‐term complication. The most important risk factor for squamous cell carcinoma development in people with dark skin is chronic scarring and inflammation, such as those seen in long‐standing discoid plaques. African Americans who develop squamous cell carcinoma in the setting of chronic scarring and inflammation have a greater risk of metastasis and recurrence compared to sun‐induced squamous cell carcinoma seen in whites. Despite this, the pathogenesis of squamous cell carcinoma development in chronic DLE is not fully understood. Herein, we describe a case of an African American patient who developed squamous cell carcinoma on a long‐standing discoid plaque. Analysis of the lesion revealed a null type pattern of p53 protein expression and abundant CD123+ plasmacytoid dendritic cells, as potential drivers of oncogenesis and inflammation, respectively. Dermatologists should be aware of the increased risk of squamous cell carcinoma development within long‐standing discoid plaques for a prompt early diagnosis and active long‐term surveillance.</description><identifier>ISSN: 0303-6987</identifier><identifier>EISSN: 1600-0560</identifier><identifier>DOI: 10.1111/cup.14304</identifier><identifier>PMID: 35922371</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>African American ; Alopecia ; Cancer ; Carcinoma, Squamous Cell - pathology ; CD123 antigen ; Cicatrix - pathology ; cutaneous lupus erythematosus ; Dendritic cells ; Dendritic Cells - pathology ; Discoid lupus erythematosus ; Humans ; Inflammation ; Inflammation - pathology ; Lupus ; Lupus Erythematosus, Discoid - complications ; Lupus Erythematosus, Discoid - pathology ; malignancy ; Metastases ; p53 Protein ; Plaques ; Risk factors ; Skin Neoplasms - pathology ; Squamous cell carcinoma ; Tumorigenesis</subject><ispartof>Journal of cutaneous pathology, 2023-01, Vol.50 (1), p.19-23</ispartof><rights>2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2504-e7018340421681397d89ffad0eefdd1b03eda63d51aa840453c96a817f6494013</citedby><cites>FETCH-LOGICAL-c2504-e7018340421681397d89ffad0eefdd1b03eda63d51aa840453c96a817f6494013</cites><orcidid>0000-0002-3239-6121 ; 0000-0001-8166-7314</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcup.14304$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcup.14304$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35922371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ju, Teresa</creatorcontrib><creatorcontrib>Ingrasci, Giuseppe</creatorcontrib><creatorcontrib>Diaz‐Perez, Julio A.</creatorcontrib><creatorcontrib>Obayomi, Aderonke</creatorcontrib><creatorcontrib>Yosipovitch, Gil</creatorcontrib><title>Development of squamous cell carcinoma in the setting of chronic discoid lupus erythematosus may be associated with plasmacytoid dendritic cell inflammation</title><title>Journal of cutaneous pathology</title><addtitle>J Cutan Pathol</addtitle><description>Discoid lupus erythematosus (DLE) is the most common type of cutaneous lupus and is clinically characterized by alopecia, depigmentation, and scars on sun‐exposed skin. Squamous cell carcinoma is a potential long‐term complication. The most important risk factor for squamous cell carcinoma development in people with dark skin is chronic scarring and inflammation, such as those seen in long‐standing discoid plaques. African Americans who develop squamous cell carcinoma in the setting of chronic scarring and inflammation have a greater risk of metastasis and recurrence compared to sun‐induced squamous cell carcinoma seen in whites. Despite this, the pathogenesis of squamous cell carcinoma development in chronic DLE is not fully understood. Herein, we describe a case of an African American patient who developed squamous cell carcinoma on a long‐standing discoid plaque. Analysis of the lesion revealed a null type pattern of p53 protein expression and abundant CD123+ plasmacytoid dendritic cells, as potential drivers of oncogenesis and inflammation, respectively. Dermatologists should be aware of the increased risk of squamous cell carcinoma development within long‐standing discoid plaques for a prompt early diagnosis and active long‐term surveillance.</description><subject>African American</subject><subject>Alopecia</subject><subject>Cancer</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>CD123 antigen</subject><subject>Cicatrix - pathology</subject><subject>cutaneous lupus erythematosus</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - pathology</subject><subject>Discoid lupus erythematosus</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - pathology</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Discoid - complications</subject><subject>Lupus Erythematosus, Discoid - pathology</subject><subject>malignancy</subject><subject>Metastases</subject><subject>p53 Protein</subject><subject>Plaques</subject><subject>Risk factors</subject><subject>Skin Neoplasms - pathology</subject><subject>Squamous cell carcinoma</subject><subject>Tumorigenesis</subject><issn>0303-6987</issn><issn>1600-0560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFO3DAQhq2KCrbAoS9QWeLUQ2AcJ05yrLaFIiHRA5wjrz3pGsV2sJ2ivAsPi5el3JiLNdI338jzE_KVwTnLdaHm6ZxVHKpPZMUEQAG1gAOyAg68EF3bHJEvMT4AMNGK-pAc8borS96wFXn-if9w9JNFl6gfaHycpfVzpArHkSoZlHHeSmocTVukEVMy7u-OVNvgnVFUm6i80XScpzyGYcmclcnH3Fm50A1SGaNXRibU9MmkLZ1GGa1US9rNaXQ6mJRNryuNG0Zps8B4d0I-D3KMePr2HpP7y19369_Fze3V9frHTaHKGqoCG2Atr6Aq8_8Y7xrddsMgNSAOWrMNcNRScF0zKduM1Vx1QrasGUTVVcD4MTnbe6fgH2eMqX_wc3B5ZV82dZfPBkJk6vueUsHHGHDop2CsDEvPoN_l0Occ-tccMvvtzThvLOp38v_hM3CxB57MiMvHpn59_2evfAHE8pUA</recordid><startdate>202301</startdate><enddate>202301</enddate><creator>Ju, Teresa</creator><creator>Ingrasci, Giuseppe</creator><creator>Diaz‐Perez, Julio A.</creator><creator>Obayomi, Aderonke</creator><creator>Yosipovitch, Gil</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><orcidid>https://orcid.org/0000-0002-3239-6121</orcidid><orcidid>https://orcid.org/0000-0001-8166-7314</orcidid></search><sort><creationdate>202301</creationdate><title>Development of squamous cell carcinoma in the setting of chronic discoid lupus erythematosus may be associated with plasmacytoid dendritic cell inflammation</title><author>Ju, Teresa ; Ingrasci, Giuseppe ; Diaz‐Perez, Julio A. ; Obayomi, Aderonke ; Yosipovitch, Gil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2504-e7018340421681397d89ffad0eefdd1b03eda63d51aa840453c96a817f6494013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>African American</topic><topic>Alopecia</topic><topic>Cancer</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>CD123 antigen</topic><topic>Cicatrix - pathology</topic><topic>cutaneous lupus erythematosus</topic><topic>Dendritic cells</topic><topic>Dendritic Cells - pathology</topic><topic>Discoid lupus erythematosus</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - pathology</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Discoid - complications</topic><topic>Lupus Erythematosus, Discoid - pathology</topic><topic>malignancy</topic><topic>Metastases</topic><topic>p53 Protein</topic><topic>Plaques</topic><topic>Risk factors</topic><topic>Skin Neoplasms - pathology</topic><topic>Squamous cell carcinoma</topic><topic>Tumorigenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ju, Teresa</creatorcontrib><creatorcontrib>Ingrasci, Giuseppe</creatorcontrib><creatorcontrib>Diaz‐Perez, Julio A.</creatorcontrib><creatorcontrib>Obayomi, Aderonke</creatorcontrib><creatorcontrib>Yosipovitch, Gil</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of cutaneous pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ju, Teresa</au><au>Ingrasci, Giuseppe</au><au>Diaz‐Perez, Julio A.</au><au>Obayomi, Aderonke</au><au>Yosipovitch, Gil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of squamous cell carcinoma in the setting of chronic discoid lupus erythematosus may be associated with plasmacytoid dendritic cell inflammation</atitle><jtitle>Journal of cutaneous pathology</jtitle><addtitle>J Cutan Pathol</addtitle><date>2023-01</date><risdate>2023</risdate><volume>50</volume><issue>1</issue><spage>19</spage><epage>23</epage><pages>19-23</pages><issn>0303-6987</issn><eissn>1600-0560</eissn><abstract>Discoid lupus erythematosus (DLE) is the most common type of cutaneous lupus and is clinically characterized by alopecia, depigmentation, and scars on sun‐exposed skin. Squamous cell carcinoma is a potential long‐term complication. The most important risk factor for squamous cell carcinoma development in people with dark skin is chronic scarring and inflammation, such as those seen in long‐standing discoid plaques. African Americans who develop squamous cell carcinoma in the setting of chronic scarring and inflammation have a greater risk of metastasis and recurrence compared to sun‐induced squamous cell carcinoma seen in whites. Despite this, the pathogenesis of squamous cell carcinoma development in chronic DLE is not fully understood. Herein, we describe a case of an African American patient who developed squamous cell carcinoma on a long‐standing discoid plaque. Analysis of the lesion revealed a null type pattern of p53 protein expression and abundant CD123+ plasmacytoid dendritic cells, as potential drivers of oncogenesis and inflammation, respectively. Dermatologists should be aware of the increased risk of squamous cell carcinoma development within long‐standing discoid plaques for a prompt early diagnosis and active long‐term surveillance.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>35922371</pmid><doi>10.1111/cup.14304</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-3239-6121</orcidid><orcidid>https://orcid.org/0000-0001-8166-7314</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0303-6987 |
| ispartof | Journal of cutaneous pathology, 2023-01, Vol.50 (1), p.19-23 |
| issn | 0303-6987 1600-0560 |
| language | eng |
| recordid | cdi_proquest_journals_2759016066 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | African American Alopecia Cancer Carcinoma, Squamous Cell - pathology CD123 antigen Cicatrix - pathology cutaneous lupus erythematosus Dendritic cells Dendritic Cells - pathology Discoid lupus erythematosus Humans Inflammation Inflammation - pathology Lupus Lupus Erythematosus, Discoid - complications Lupus Erythematosus, Discoid - pathology malignancy Metastases p53 Protein Plaques Risk factors Skin Neoplasms - pathology Squamous cell carcinoma Tumorigenesis |
| title | Development of squamous cell carcinoma in the setting of chronic discoid lupus erythematosus may be associated with plasmacytoid dendritic cell inflammation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T23%3A13%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20of%20squamous%20cell%20carcinoma%20in%20the%20setting%20of%20chronic%20discoid%20lupus%20erythematosus%20may%20be%20associated%20with%20plasmacytoid%20dendritic%20cell%20inflammation&rft.jtitle=Journal%20of%20cutaneous%20pathology&rft.au=Ju,%20Teresa&rft.date=2023-01&rft.volume=50&rft.issue=1&rft.spage=19&rft.epage=23&rft.pages=19-23&rft.issn=0303-6987&rft.eissn=1600-0560&rft_id=info:doi/10.1111/cup.14304&rft_dat=%3Cproquest_cross%3E2759016066%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2759016066&rft_id=info:pmid/35922371&rfr_iscdi=true |