A pan‑cancer analysis of RCC2 and its interaction with HMGA2 protein in an in vitro model of colorectal cancer cells
Regulator of chromosome condensation 2 (RCC2) is highly involved in the development of tumor malignancies. The underlying mechanisms remain to be elucidated. The present study aimed to explore the role of RCC2 in the development of tumor malignancies and explore the underlying mechanisms in colorect...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2022-12, Vol.24 (6), Article 725 |
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| creator | Gu, Guiyuan Wang, Yuhong Shen, Yucheng Ma, Yan Yang, Hongli Huang, Shan Hu, Lin |
| description | Regulator of chromosome condensation 2 (RCC2) is highly involved in the development of tumor malignancies. The underlying mechanisms remain to be elucidated. The present study aimed to explore the role of RCC2 in the development of tumor malignancies and explore the underlying mechanisms in colorectal cancer (CRC). RCC2 expression and survival analysis were performed in human pan-cancer. The results of searching its mRNA expression in The Cancer Genome Atlas (TCGA) database showed that RCC2 was highly expressed in different types of cancer. High RCC2 expression levels were significantly correlated with poor survival outcomes by the Kaplan-Meier analysis in the TCGA database. Immunohistochemistry revealed that RCC2 was higher expressed in 36 CRC tissues than in adjacent normal tissues. Co-immunoprecipitation revealed that RCC2 bound to high mobility group A2 (HMGA2). Ectopic expression of RCC2 promoted cell proliferation, migration and invasion, whereas knockdown of HMGA2 exerted the opposite effects. Collectively, the data provided a novel biomarker of RCC2 in various types of cancer. High RCC2 expression levels were correlated with poor prognosis in different types of cancer. In addition, RCC2 may combine with HMGA2 to promote CRC malignancy. |
| doi_str_mv | 10.3892/etm.2022.11661 |
| format | Article |
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The underlying mechanisms remain to be elucidated. The present study aimed to explore the role of RCC2 in the development of tumor malignancies and explore the underlying mechanisms in colorectal cancer (CRC). RCC2 expression and survival analysis were performed in human pan-cancer. The results of searching its mRNA expression in The Cancer Genome Atlas (TCGA) database showed that RCC2 was highly expressed in different types of cancer. High RCC2 expression levels were significantly correlated with poor survival outcomes by the Kaplan-Meier analysis in the TCGA database. Immunohistochemistry revealed that RCC2 was higher expressed in 36 CRC tissues than in adjacent normal tissues. Co-immunoprecipitation revealed that RCC2 bound to high mobility group A2 (HMGA2). Ectopic expression of RCC2 promoted cell proliferation, migration and invasion, whereas knockdown of HMGA2 exerted the opposite effects. Collectively, the data provided a novel biomarker of RCC2 in various types of cancer. High RCC2 expression levels were correlated with poor prognosis in different types of cancer. In addition, RCC2 may combine with HMGA2 to promote CRC malignancy.</description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2022.11661</identifier><language>eng</language><publisher>Athens: Spandidos Publications</publisher><subject>Antibodies ; Biotechnology ; Care and treatment ; Cell growth ; Colorectal cancer ; Datasets ; Development and progression ; Digestive system ; Endometrial cancer ; Gene expression ; Genetic aspects ; Health aspects ; Liver cancer ; Medical prognosis ; Mesothelioma ; Metastasis ; Prostate cancer ; Proteins ; Sarcoma ; Transcription factors ; Tumorigenesis ; Tumors</subject><ispartof>Experimental and therapeutic medicine, 2022-12, Vol.24 (6), Article 725</ispartof><rights>COPYRIGHT 2022 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2022</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-32d3f61fbb9b0fffcca19b002138aa31199128ca077de073a93f9e69b26ebcf03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids></links><search><creatorcontrib>Gu, Guiyuan</creatorcontrib><creatorcontrib>Wang, Yuhong</creatorcontrib><creatorcontrib>Shen, Yucheng</creatorcontrib><creatorcontrib>Ma, Yan</creatorcontrib><creatorcontrib>Yang, Hongli</creatorcontrib><creatorcontrib>Huang, Shan</creatorcontrib><creatorcontrib>Hu, Lin</creatorcontrib><title>A pan‑cancer analysis of RCC2 and its interaction with HMGA2 protein in an in vitro model of colorectal cancer cells</title><title>Experimental and therapeutic medicine</title><description>Regulator of chromosome condensation 2 (RCC2) is highly involved in the development of tumor malignancies. The underlying mechanisms remain to be elucidated. The present study aimed to explore the role of RCC2 in the development of tumor malignancies and explore the underlying mechanisms in colorectal cancer (CRC). RCC2 expression and survival analysis were performed in human pan-cancer. The results of searching its mRNA expression in The Cancer Genome Atlas (TCGA) database showed that RCC2 was highly expressed in different types of cancer. High RCC2 expression levels were significantly correlated with poor survival outcomes by the Kaplan-Meier analysis in the TCGA database. Immunohistochemistry revealed that RCC2 was higher expressed in 36 CRC tissues than in adjacent normal tissues. Co-immunoprecipitation revealed that RCC2 bound to high mobility group A2 (HMGA2). Ectopic expression of RCC2 promoted cell proliferation, migration and invasion, whereas knockdown of HMGA2 exerted the opposite effects. Collectively, the data provided a novel biomarker of RCC2 in various types of cancer. High RCC2 expression levels were correlated with poor prognosis in different types of cancer. In addition, RCC2 may combine with HMGA2 to promote CRC malignancy.</description><subject>Antibodies</subject><subject>Biotechnology</subject><subject>Care and treatment</subject><subject>Cell growth</subject><subject>Colorectal cancer</subject><subject>Datasets</subject><subject>Development and progression</subject><subject>Digestive system</subject><subject>Endometrial cancer</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Liver cancer</subject><subject>Medical prognosis</subject><subject>Mesothelioma</subject><subject>Metastasis</subject><subject>Prostate cancer</subject><subject>Proteins</subject><subject>Sarcoma</subject><subject>Transcription factors</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptUc1KAzEQXkTBUnv1HPC8NT_ubnJcFm2FiiB6DtlsoinZTU1SS2--gm_gs_goPompFrx0BmaGmW_--LLsHMEpoQxfqthPMcR4ilBZoqNshCqGcwRRcbyPIaPoNJuEsIRJihJRWoyyTQ1WYvh-_5BikMoDMQi7DSYAp8FD0-CU6ICJAZghKi9kNG4AGxNfwPxuVmOw8i4qM6RyQib79flmonegd52yuyHSWeeVjMKC_QqprA1n2YkWNqjJ3o-zp5vrx2aeL-5nt029yCUhVcwJ7ogukW5b1kKttZQCpQhiRKgQBCHGEKZSwKrqFKyIYEQzVbIWl6qVGpJxdvE3Nx36ulYh8qVb-_Rk4LgqKCuK1P-PehZWcTNoF9OvvQmS1xW5KiGFpEio6QFU0k71RrpBaZPyhxqkdyF4pfnKm174LUeQ72jjiTa-o43_0kZ-AOr8iuM</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Gu, Guiyuan</creator><creator>Wang, Yuhong</creator><creator>Shen, Yucheng</creator><creator>Ma, Yan</creator><creator>Yang, Hongli</creator><creator>Huang, Shan</creator><creator>Hu, Lin</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20221201</creationdate><title>A pan‑cancer analysis of RCC2 and its interaction with HMGA2 protein in an in vitro model of colorectal cancer cells</title><author>Gu, Guiyuan ; Wang, Yuhong ; Shen, Yucheng ; Ma, Yan ; Yang, Hongli ; Huang, Shan ; Hu, Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-32d3f61fbb9b0fffcca19b002138aa31199128ca077de073a93f9e69b26ebcf03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antibodies</topic><topic>Biotechnology</topic><topic>Care and treatment</topic><topic>Cell growth</topic><topic>Colorectal cancer</topic><topic>Datasets</topic><topic>Development and progression</topic><topic>Digestive system</topic><topic>Endometrial cancer</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Liver cancer</topic><topic>Medical prognosis</topic><topic>Mesothelioma</topic><topic>Metastasis</topic><topic>Prostate cancer</topic><topic>Proteins</topic><topic>Sarcoma</topic><topic>Transcription factors</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><toplevel>online_resources</toplevel><creatorcontrib>Gu, Guiyuan</creatorcontrib><creatorcontrib>Wang, Yuhong</creatorcontrib><creatorcontrib>Shen, Yucheng</creatorcontrib><creatorcontrib>Ma, Yan</creatorcontrib><creatorcontrib>Yang, Hongli</creatorcontrib><creatorcontrib>Huang, Shan</creatorcontrib><creatorcontrib>Hu, Lin</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Experimental and therapeutic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gu, Guiyuan</au><au>Wang, Yuhong</au><au>Shen, Yucheng</au><au>Ma, Yan</au><au>Yang, Hongli</au><au>Huang, Shan</au><au>Hu, Lin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A pan‑cancer analysis of RCC2 and its interaction with HMGA2 protein in an in vitro model of colorectal cancer cells</atitle><jtitle>Experimental and therapeutic medicine</jtitle><date>2022-12-01</date><risdate>2022</risdate><volume>24</volume><issue>6</issue><artnum>725</artnum><issn>1792-0981</issn><eissn>1792-1015</eissn><abstract>Regulator of chromosome condensation 2 (RCC2) is highly involved in the development of tumor malignancies. The underlying mechanisms remain to be elucidated. The present study aimed to explore the role of RCC2 in the development of tumor malignancies and explore the underlying mechanisms in colorectal cancer (CRC). RCC2 expression and survival analysis were performed in human pan-cancer. The results of searching its mRNA expression in The Cancer Genome Atlas (TCGA) database showed that RCC2 was highly expressed in different types of cancer. High RCC2 expression levels were significantly correlated with poor survival outcomes by the Kaplan-Meier analysis in the TCGA database. Immunohistochemistry revealed that RCC2 was higher expressed in 36 CRC tissues than in adjacent normal tissues. Co-immunoprecipitation revealed that RCC2 bound to high mobility group A2 (HMGA2). Ectopic expression of RCC2 promoted cell proliferation, migration and invasion, whereas knockdown of HMGA2 exerted the opposite effects. Collectively, the data provided a novel biomarker of RCC2 in various types of cancer. High RCC2 expression levels were correlated with poor prognosis in different types of cancer. In addition, RCC2 may combine with HMGA2 to promote CRC malignancy.</abstract><cop>Athens</cop><pub>Spandidos Publications</pub><doi>10.3892/etm.2022.11661</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Antibodies Biotechnology Care and treatment Cell growth Colorectal cancer Datasets Development and progression Digestive system Endometrial cancer Gene expression Genetic aspects Health aspects Liver cancer Medical prognosis Mesothelioma Metastasis Prostate cancer Proteins Sarcoma Transcription factors Tumorigenesis Tumors |
| title | A pan‑cancer analysis of RCC2 and its interaction with HMGA2 protein in an in vitro model of colorectal cancer cells |
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