IN SILICO STUDY OF THE CORTICAL NEURON REVEALS VASOCONSTRICTIVE EFFECTS OF COCAINE MODULATES THE FIRING PATTERNS BY INHIBITING SMALL CONDUCTANCE CALCIUM‑ACTIVATED POTASSIUM CURRENT

The vasoconstrictive effects of cocaine modulate the neuronal firing patterns which could contribute to Parkinson's disease (PD). This quantitative study investigates action potential (AP) oscillation patterns of cortical neurons towards the cocaine exposure. This single compartmental in silico...

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Veröffentlicht in:	Acta neurobiologiae experimentalis 2022-01, Vol.82, p.LXV
Hauptverfasser:	Mahapatra, Chitaranjan, Pradhan, Ashish Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Calcium Calcium channels Calcium channels (voltage-gated) Calcium conductance Cocaine Electric potential Excitability Firing pattern Firing rate Ion channels Movement disorders Neurodegenerative diseases Neurons Parkinson's disease Potassium Potassium channels (voltage-gated) Potassium conductance Voltage
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