mRNA Expression of GATA3, FOXP3, TBX21, STAT3, NFKB1, and MAPK8 Transcription Factors in Humans and Their Cooperative Interactions Long-Term after Exposure to Chronic Radiation
The results of mRNA expression of the GATA3, FOXP3, TBX21, STAT3, NFKB1, and MAPK8 transcription factors in peripheral blood cells of 264 residents of the Techa riverside villages of the Chelyabinsk and Kurgan regions, who were affected by chronic low dose-rate exposure in the 1950s, are shown. The...
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| Veröffentlicht in: | Biology bulletin of the Russian Academy of Sciences 2022-12, Vol.49 (6), p.588-595 |
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| description | The results of mRNA expression of the GATA3, FOXP3, TBX21, STAT3, NFKB1, and MAPK8 transcription factors in peripheral blood cells of 264 residents of the Techa riverside villages of the Chelyabinsk and Kurgan regions, who were affected by chronic low dose-rate exposure in the 1950s, are shown. The range of individual doses to the red bone marrow due to external gamma exposure and
90
Sr was 77.8–3507.1 mGy, and the mean dose was 706.3±46.3 mGy. It has been found that changes in the transcriptional response of the cell occur at the molecular level in the long term after chronic exposure. A modified expression of the immunoregulatory genes
NFKB1
and
MAPK8
in the peripheral blood cells of exposed people was found. A comparative analysis of the interaction of the studied mRNAs demonstrated the presence of a link between the
MAPK8
and
NFKB1
genes in the group of chronically exposed individuals. The results obtained may indicate the involvement of these transcription factors in the impairment of the immune response in the exposed population. |
| doi_str_mv | 10.1134/S1062359022060103 |
| format | Article |
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90
Sr was 77.8–3507.1 mGy, and the mean dose was 706.3±46.3 mGy. It has been found that changes in the transcriptional response of the cell occur at the molecular level in the long term after chronic exposure. A modified expression of the immunoregulatory genes
NFKB1
and
MAPK8
in the peripheral blood cells of exposed people was found. A comparative analysis of the interaction of the studied mRNAs demonstrated the presence of a link between the
MAPK8
and
NFKB1
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90
Sr was 77.8–3507.1 mGy, and the mean dose was 706.3±46.3 mGy. It has been found that changes in the transcriptional response of the cell occur at the molecular level in the long term after chronic exposure. A modified expression of the immunoregulatory genes
NFKB1
and
MAPK8
in the peripheral blood cells of exposed people was found. A comparative analysis of the interaction of the studied mRNAs demonstrated the presence of a link between the
MAPK8
and
NFKB1
genes in the group of chronically exposed individuals. The results obtained may indicate the involvement of these transcription factors in the impairment of the immune response in the exposed population.</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Blood cells</subject><subject>Bone marrow</subject><subject>Cell Biology</subject><subject>Chronic exposure</subject><subject>Comparative analysis</subject><subject>Ecology</subject><subject>Foxp3 protein</subject><subject>GATA-3 protein</subject><subject>Gene expression</subject><subject>Genetics</subject><subject>Immune response</subject><subject>Immunoregulation</subject><subject>Life Sciences</subject><subject>Peripheral blood</subject><subject>Stat3 protein</subject><subject>Strontium</subject><subject>Transcription factors</subject><subject>Zoology</subject><issn>1062-3590</issn><issn>1608-3059</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp1kctOwzAQRSMEElD4AHaW2BIYP5K6y1DRh1po1Qapu8h17BJE7WCnCP6KT8ShSCwQq3nce2ZGmii6wHCNMWU3SwwpoUkPCIEUMNCD6ASnwGMKSe8w5EGOW_04OvX-GQAYZeQk-twuHjJ091475X1lDbIaDbM8o1doMFvNQ8hvVwRfoWWe5aF6GExuQyVMie6z-YSj3AnjpavqpqUHQjbWeVQZNNptg_LtzJ9U5VDf2lo50VRvCo1NE1LZMh5NrdnEuXJbJHRot9dYv3MKNRb1n5w1lUQLUVaitZ9FR1q8eHX-EzvR4-Au74_i6Ww47mfTWFKMmxhL4FwpkWiWpmWp1l3WWyuCWaIYlqwLWggsgqb5mkq95oQnHEjJNICUjNNOdLmfWzv7ulO-KZ7tzpmwsiDdJOE9TFIWXHjvks5675QualdthfsoMBTtY4o_jwkM2TM-eM1Gud_J_0NfNNiNMg</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Nikiforov, V. S.</creator><creator>Akleyev, A. V.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20221201</creationdate><title>mRNA Expression of GATA3, FOXP3, TBX21, STAT3, NFKB1, and MAPK8 Transcription Factors in Humans and Their Cooperative Interactions Long-Term after Exposure to Chronic Radiation</title><author>Nikiforov, V. S. ; Akleyev, A. V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-1c088eea5f466ddeb749be2145e41c470faa1a466f8b3cfb8285802d4f00cc483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Blood cells</topic><topic>Bone marrow</topic><topic>Cell Biology</topic><topic>Chronic exposure</topic><topic>Comparative analysis</topic><topic>Ecology</topic><topic>Foxp3 protein</topic><topic>GATA-3 protein</topic><topic>Gene expression</topic><topic>Genetics</topic><topic>Immune response</topic><topic>Immunoregulation</topic><topic>Life Sciences</topic><topic>Peripheral blood</topic><topic>Stat3 protein</topic><topic>Strontium</topic><topic>Transcription factors</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nikiforov, V. S.</creatorcontrib><creatorcontrib>Akleyev, A. V.</creatorcontrib><collection>SpringerOpen</collection><collection>CrossRef</collection><jtitle>Biology bulletin of the Russian Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nikiforov, V. S.</au><au>Akleyev, A. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>mRNA Expression of GATA3, FOXP3, TBX21, STAT3, NFKB1, and MAPK8 Transcription Factors in Humans and Their Cooperative Interactions Long-Term after Exposure to Chronic Radiation</atitle><jtitle>Biology bulletin of the Russian Academy of Sciences</jtitle><stitle>Biol Bull Russ Acad Sci</stitle><date>2022-12-01</date><risdate>2022</risdate><volume>49</volume><issue>6</issue><spage>588</spage><epage>595</epage><pages>588-595</pages><issn>1062-3590</issn><eissn>1608-3059</eissn><abstract>The results of mRNA expression of the GATA3, FOXP3, TBX21, STAT3, NFKB1, and MAPK8 transcription factors in peripheral blood cells of 264 residents of the Techa riverside villages of the Chelyabinsk and Kurgan regions, who were affected by chronic low dose-rate exposure in the 1950s, are shown. The range of individual doses to the red bone marrow due to external gamma exposure and
90
Sr was 77.8–3507.1 mGy, and the mean dose was 706.3±46.3 mGy. It has been found that changes in the transcriptional response of the cell occur at the molecular level in the long term after chronic exposure. A modified expression of the immunoregulatory genes
NFKB1
and
MAPK8
in the peripheral blood cells of exposed people was found. A comparative analysis of the interaction of the studied mRNAs demonstrated the presence of a link between the
MAPK8
and
NFKB1
genes in the group of chronically exposed individuals. The results obtained may indicate the involvement of these transcription factors in the impairment of the immune response in the exposed population.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1062359022060103</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biochemistry Biomedical and Life Sciences Blood cells Bone marrow Cell Biology Chronic exposure Comparative analysis Ecology Foxp3 protein GATA-3 protein Gene expression Genetics Immune response Immunoregulation Life Sciences Peripheral blood Stat3 protein Strontium Transcription factors Zoology |
| title | mRNA Expression of GATA3, FOXP3, TBX21, STAT3, NFKB1, and MAPK8 Transcription Factors in Humans and Their Cooperative Interactions Long-Term after Exposure to Chronic Radiation |
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