Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry
Background Breast asymmetry is a prevalent mammographic finding described in BI-RADS atlas as asymmetry, focal asymmetry, global asymmetry, and developing asymmetry. Mammography has a limited role in discrimination between benign and malignant asymmetry, and digital mammography can overlook up to 15...
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| Veröffentlicht in: | Egyptian Journal of Radiology and Nuclear Medicine 2022-12, Vol.53 (1), p.259-13, Article 259 |
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| container_title | Egyptian Journal of Radiology and Nuclear Medicine |
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| creator | Dawoud, Bassant Mahmoud Darweesh, Abdelmonem Nooman Hefeda, Mohamed Mohamed Kamal, Rasha Mohamed Younis, Rasha Lotfy |
| description | Background
Breast asymmetry is a prevalent mammographic finding described in BI-RADS atlas as asymmetry, focal asymmetry, global asymmetry, and developing asymmetry. Mammography has a limited role in discrimination between benign and malignant asymmetry, and digital mammography can overlook up to 15–30% of breast tumors. The purpose of our study was to assess the role of contrast-enhanced mammography (CEM) in distinction between benign and malignant asymmetries.
Results
Out of the studied 540 indeterminate and suspicious asymmetries, and according to final histopathological results, 97/540 (17.9%) asymmetries were benign, 395/540(73%) asymmetries were malignant, 48/540 (8.9%) asymmetries were normal with no underlying pathology. After comparing results of sonomammography and CEM, CEM showed higher sensitivity (96.5% vs. 85.8), specificity (77.1% vs. 64.4%), NPV (88.8% vs. 62.7%), PPV (92.04% vs. 86.7%) and accuracy (91.3% vs. 80%).
Conclusions
CEM has proven to be a valuable and beneficial imaging technicality for patients and radiologists, with breast cancer detection sensitivities superior to that of full-field digital mammography (FFDM) with ultrasonography (US). |
| doi_str_mv | 10.1186/s43055-022-00943-5 |
| format | Article |
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Breast asymmetry is a prevalent mammographic finding described in BI-RADS atlas as asymmetry, focal asymmetry, global asymmetry, and developing asymmetry. Mammography has a limited role in discrimination between benign and malignant asymmetry, and digital mammography can overlook up to 15–30% of breast tumors. The purpose of our study was to assess the role of contrast-enhanced mammography (CEM) in distinction between benign and malignant asymmetries.
Results
Out of the studied 540 indeterminate and suspicious asymmetries, and according to final histopathological results, 97/540 (17.9%) asymmetries were benign, 395/540(73%) asymmetries were malignant, 48/540 (8.9%) asymmetries were normal with no underlying pathology. After comparing results of sonomammography and CEM, CEM showed higher sensitivity (96.5% vs. 85.8), specificity (77.1% vs. 64.4%), NPV (88.8% vs. 62.7%), PPV (92.04% vs. 86.7%) and accuracy (91.3% vs. 80%).
Conclusions
CEM has proven to be a valuable and beneficial imaging technicality for patients and radiologists, with breast cancer detection sensitivities superior to that of full-field digital mammography (FFDM) with ultrasonography (US).</description><identifier>ISSN: 2090-4762</identifier><identifier>ISSN: 0378-603X</identifier><identifier>EISSN: 2090-4762</identifier><identifier>DOI: 10.1186/s43055-022-00943-5</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Asymmetry ; Biopsy ; Breast cancer ; Cancer therapies ; Contrast-enhanced mammography (CEM) ; Edema ; Energy ; Hormone replacement therapy ; Imaging ; Iodine ; Laboratories ; Mammography ; Medical imaging equipment ; Medicine ; Medicine & Public Health ; Morphology ; Nuclear Medicine ; Patients ; Radiology ; Ultrasonic imaging</subject><ispartof>Egyptian Journal of Radiology and Nuclear Medicine, 2022-12, Vol.53 (1), p.259-13, Article 259</ispartof><rights>The Author(s) 2022</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-f05743f49a0bdf0a5de81bde200108d2e3c0e51ee9baed0df0c958a550e0f7483</citedby><cites>FETCH-LOGICAL-c496t-f05743f49a0bdf0a5de81bde200108d2e3c0e51ee9baed0df0c958a550e0f7483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,861,27905,27906</link.rule.ids></links><search><creatorcontrib>Dawoud, Bassant Mahmoud</creatorcontrib><creatorcontrib>Darweesh, Abdelmonem Nooman</creatorcontrib><creatorcontrib>Hefeda, Mohamed Mohamed</creatorcontrib><creatorcontrib>Kamal, Rasha Mohamed</creatorcontrib><creatorcontrib>Younis, Rasha Lotfy</creatorcontrib><title>Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry</title><title>Egyptian Journal of Radiology and Nuclear Medicine</title><addtitle>Egypt J Radiol Nucl Med</addtitle><description>Background
Breast asymmetry is a prevalent mammographic finding described in BI-RADS atlas as asymmetry, focal asymmetry, global asymmetry, and developing asymmetry. Mammography has a limited role in discrimination between benign and malignant asymmetry, and digital mammography can overlook up to 15–30% of breast tumors. The purpose of our study was to assess the role of contrast-enhanced mammography (CEM) in distinction between benign and malignant asymmetries.
Results
Out of the studied 540 indeterminate and suspicious asymmetries, and according to final histopathological results, 97/540 (17.9%) asymmetries were benign, 395/540(73%) asymmetries were malignant, 48/540 (8.9%) asymmetries were normal with no underlying pathology. After comparing results of sonomammography and CEM, CEM showed higher sensitivity (96.5% vs. 85.8), specificity (77.1% vs. 64.4%), NPV (88.8% vs. 62.7%), PPV (92.04% vs. 86.7%) and accuracy (91.3% vs. 80%).
Conclusions
CEM has proven to be a valuable and beneficial imaging technicality for patients and radiologists, with breast cancer detection sensitivities superior to that of full-field digital mammography (FFDM) with ultrasonography (US).</description><subject>Asymmetry</subject><subject>Biopsy</subject><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Contrast-enhanced mammography (CEM)</subject><subject>Edema</subject><subject>Energy</subject><subject>Hormone replacement therapy</subject><subject>Imaging</subject><subject>Iodine</subject><subject>Laboratories</subject><subject>Mammography</subject><subject>Medical imaging equipment</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Morphology</subject><subject>Nuclear Medicine</subject><subject>Patients</subject><subject>Radiology</subject><subject>Ultrasonic imaging</subject><issn>2090-4762</issn><issn>0378-603X</issn><issn>2090-4762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNp9kU9r3DAQxU1oISHNF-jJ0LPTkSXZ1jGkfxII9NIeixhLI6-WtbSVvIXtp682LkkKpdJBYni_x8y8qnrL4JqxoXufBQcpG2jbBkAJ3siz6qIFBY3ou_bVi_95dZXzFsoRAKwTF9X3Dx6nEPPiTf0Tdweqo6tNDEvCvDQUNhgM2XrGeY5Twv3mWPtQLxuqzQYTmoWS_4WLj-EEjokKVmM-zjMt6fimeu1wl-nqz3tZffv08evtXfPw5fP97c1DY4TqlsaB7AV3QiGM1gFKSwMbLbWlSRhsS9wASUakRiQLRWKUHFBKIHC9GPhldb_62ohbvU9-xnTUEb1-LMQ0aUxlxB1pdcLQGFbshO34qHo3CBiUNQSGU_F6t3rtU_xxoLzobTykUNrXbV9Yxno1PKsmLKY-uFg2Zmafjb7pOQimJOuL6vofqnItzb5smZwv9b-AdgVMijknck_DMNCnsPUati5h68ewtSwQX6FcxGGi9Nzxf6jfDeqsTg</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Dawoud, Bassant Mahmoud</creator><creator>Darweesh, Abdelmonem Nooman</creator><creator>Hefeda, Mohamed Mohamed</creator><creator>Kamal, Rasha Mohamed</creator><creator>Younis, Rasha Lotfy</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>DOA</scope></search><sort><creationdate>20221201</creationdate><title>Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry</title><author>Dawoud, Bassant Mahmoud ; Darweesh, Abdelmonem Nooman ; Hefeda, Mohamed Mohamed ; Kamal, Rasha Mohamed ; Younis, Rasha Lotfy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-f05743f49a0bdf0a5de81bde200108d2e3c0e51ee9baed0df0c958a550e0f7483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Asymmetry</topic><topic>Biopsy</topic><topic>Breast cancer</topic><topic>Cancer therapies</topic><topic>Contrast-enhanced mammography (CEM)</topic><topic>Edema</topic><topic>Energy</topic><topic>Hormone replacement therapy</topic><topic>Imaging</topic><topic>Iodine</topic><topic>Laboratories</topic><topic>Mammography</topic><topic>Medical imaging equipment</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Morphology</topic><topic>Nuclear Medicine</topic><topic>Patients</topic><topic>Radiology</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dawoud, Bassant Mahmoud</creatorcontrib><creatorcontrib>Darweesh, Abdelmonem Nooman</creatorcontrib><creatorcontrib>Hefeda, Mohamed Mohamed</creatorcontrib><creatorcontrib>Kamal, Rasha Mohamed</creatorcontrib><creatorcontrib>Younis, Rasha Lotfy</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Egyptian Journal of Radiology and Nuclear Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dawoud, Bassant Mahmoud</au><au>Darweesh, Abdelmonem Nooman</au><au>Hefeda, Mohamed Mohamed</au><au>Kamal, Rasha Mohamed</au><au>Younis, Rasha Lotfy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry</atitle><jtitle>Egyptian Journal of Radiology and Nuclear Medicine</jtitle><stitle>Egypt J Radiol Nucl Med</stitle><date>2022-12-01</date><risdate>2022</risdate><volume>53</volume><issue>1</issue><spage>259</spage><epage>13</epage><pages>259-13</pages><artnum>259</artnum><issn>2090-4762</issn><issn>0378-603X</issn><eissn>2090-4762</eissn><abstract>Background
Breast asymmetry is a prevalent mammographic finding described in BI-RADS atlas as asymmetry, focal asymmetry, global asymmetry, and developing asymmetry. Mammography has a limited role in discrimination between benign and malignant asymmetry, and digital mammography can overlook up to 15–30% of breast tumors. The purpose of our study was to assess the role of contrast-enhanced mammography (CEM) in distinction between benign and malignant asymmetries.
Results
Out of the studied 540 indeterminate and suspicious asymmetries, and according to final histopathological results, 97/540 (17.9%) asymmetries were benign, 395/540(73%) asymmetries were malignant, 48/540 (8.9%) asymmetries were normal with no underlying pathology. After comparing results of sonomammography and CEM, CEM showed higher sensitivity (96.5% vs. 85.8), specificity (77.1% vs. 64.4%), NPV (88.8% vs. 62.7%), PPV (92.04% vs. 86.7%) and accuracy (91.3% vs. 80%).
Conclusions
CEM has proven to be a valuable and beneficial imaging technicality for patients and radiologists, with breast cancer detection sensitivities superior to that of full-field digital mammography (FFDM) with ultrasonography (US).</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43055-022-00943-5</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Egyptian Journal of Radiology and Nuclear Medicine, 2022-12, Vol.53 (1), p.259-13, Article 259 |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature OA/Free Journals |
| subjects | Asymmetry Biopsy Breast cancer Cancer therapies Contrast-enhanced mammography (CEM) Edema Energy Hormone replacement therapy Imaging Iodine Laboratories Mammography Medical imaging equipment Medicine Medicine & Public Health Morphology Nuclear Medicine Patients Radiology Ultrasonic imaging |
| title | Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry |
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