Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy
The development of novel wound dressings, such as aerogels, with rapid hemostasis and bactericidal capacities for pre-hospital care is necessary. To prevent the occurrence of bacterial resistance, antibacterial photodynamic therapy (aPDT) with broad-spectrum antibacterial ability and negligible bact...
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| Veröffentlicht in: | Drug delivery 2022-12, Vol.29 (1), p.1086-1099 |
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| creator | Guo, Ning Xia, Yu Zeng, Weishen Chen, Jia Wu, Quanxin Shi, Yaxin Li, Guoying Huang, Zhuoyi Wang, Guanhai Liu, Yun |
| description | The development of novel wound dressings, such as aerogels, with rapid hemostasis and bactericidal capacities for pre-hospital care is necessary. To prevent the occurrence of bacterial resistance, antibacterial photodynamic therapy (aPDT) with broad-spectrum antibacterial ability and negligible bacterial resistance has been intensively studied. However, photosensitizers often suffer from poor water solubility, short singlet oxygen (
1
O
2
) half-life and restricted
1
O
2
diffusion distance. Herein, sodium alginate was covalently modified by photosensitizers and phenylboronic acid, and cross-linked by Ca(II) ions to generate SA@TPAPP@PBA aerogel after lyophilization as an antibacterial photodynamic wound dressing. Afterwards, its photodynamic and bacterial capture activities were intensively evaluated. Furthermore, its hemostasis and bactericidal efficiency against Staphylococcus aureus were assessed via in vitro and in vivo assays. First, chemical immobilization of photosensitizers led to an enhancement of its solubility. Moreover, it showed an excellent hemostasis capacity. Due to the formation of reversible covalent bonds between phenylboronic acid and diol groups on bacterial cell surface, the aerogel could capture S. aureus tightly and dramatically enhance aPDT. To sum up, the prepared aerogel illustrated excellent hemostasis capacity and antibacterial ability against S. aureus. Therefore, they have great potential to be utilized as wound dressing in clinical trials. |
| doi_str_mv | 10.1080/10717544.2022.2058650 |
| format | Article |
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1
O
2
) half-life and restricted
1
O
2
diffusion distance. Herein, sodium alginate was covalently modified by photosensitizers and phenylboronic acid, and cross-linked by Ca(II) ions to generate SA@TPAPP@PBA aerogel after lyophilization as an antibacterial photodynamic wound dressing. Afterwards, its photodynamic and bacterial capture activities were intensively evaluated. Furthermore, its hemostasis and bactericidal efficiency against Staphylococcus aureus were assessed via in vitro and in vivo assays. First, chemical immobilization of photosensitizers led to an enhancement of its solubility. Moreover, it showed an excellent hemostasis capacity. Due to the formation of reversible covalent bonds between phenylboronic acid and diol groups on bacterial cell surface, the aerogel could capture S. aureus tightly and dramatically enhance aPDT. To sum up, the prepared aerogel illustrated excellent hemostasis capacity and antibacterial ability against S. aureus. Therefore, they have great potential to be utilized as wound dressing in clinical trials.</description><identifier>ISSN: 1071-7544</identifier><identifier>EISSN: 1521-0464</identifier><identifier>DOI: 10.1080/10717544.2022.2058650</identifier><identifier>PMID: 35373683</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Acids ; aerogels ; Alginate ; Alginates - chemistry ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; antibacterial photodynamic therapy ; Antibiotics ; bacterial capture ; Bacterial infections ; Bandages ; Biocompatibility ; Clinical trials ; Efficiency ; Gels ; Glycoproteins ; Hospitalization ; Hydrogels ; Laboratories ; Pharmacy ; Photochemotherapy ; Photodynamic therapy ; R&D ; Research & development ; Skin ; Staphylococcus aureus ; Trauma ; wound dressings ; Wounds and Injuries - microbiology ; Wounds and Injuries - therapy</subject><ispartof>Drug delivery, 2022-12, Vol.29 (1), p.1086-1099</ispartof><rights>2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2022</rights><rights>2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2022 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-e8819d0550ea89af7832e1700f6b9269a58d012416d7477b00012f3e8cba8abf3</citedby><cites>FETCH-LOGICAL-c492t-e8819d0550ea89af7832e1700f6b9269a58d012416d7477b00012f3e8cba8abf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048949/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048949/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,27479,27901,27902,53766,53768,59116,59117</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35373683$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Ning</creatorcontrib><creatorcontrib>Xia, Yu</creatorcontrib><creatorcontrib>Zeng, Weishen</creatorcontrib><creatorcontrib>Chen, Jia</creatorcontrib><creatorcontrib>Wu, Quanxin</creatorcontrib><creatorcontrib>Shi, Yaxin</creatorcontrib><creatorcontrib>Li, Guoying</creatorcontrib><creatorcontrib>Huang, Zhuoyi</creatorcontrib><creatorcontrib>Wang, Guanhai</creatorcontrib><creatorcontrib>Liu, Yun</creatorcontrib><title>Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy</title><title>Drug delivery</title><addtitle>Drug Deliv</addtitle><description>The development of novel wound dressings, such as aerogels, with rapid hemostasis and bactericidal capacities for pre-hospital care is necessary. To prevent the occurrence of bacterial resistance, antibacterial photodynamic therapy (aPDT) with broad-spectrum antibacterial ability and negligible bacterial resistance has been intensively studied. However, photosensitizers often suffer from poor water solubility, short singlet oxygen (
1
O
2
) half-life and restricted
1
O
2
diffusion distance. Herein, sodium alginate was covalently modified by photosensitizers and phenylboronic acid, and cross-linked by Ca(II) ions to generate SA@TPAPP@PBA aerogel after lyophilization as an antibacterial photodynamic wound dressing. Afterwards, its photodynamic and bacterial capture activities were intensively evaluated. Furthermore, its hemostasis and bactericidal efficiency against Staphylococcus aureus were assessed via in vitro and in vivo assays. First, chemical immobilization of photosensitizers led to an enhancement of its solubility. Moreover, it showed an excellent hemostasis capacity. Due to the formation of reversible covalent bonds between phenylboronic acid and diol groups on bacterial cell surface, the aerogel could capture S. aureus tightly and dramatically enhance aPDT. To sum up, the prepared aerogel illustrated excellent hemostasis capacity and antibacterial ability against S. aureus. Therefore, they have great potential to be utilized as wound dressing in clinical trials.</description><subject>Acids</subject><subject>aerogels</subject><subject>Alginate</subject><subject>Alginates - chemistry</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>antibacterial photodynamic therapy</subject><subject>Antibiotics</subject><subject>bacterial capture</subject><subject>Bacterial infections</subject><subject>Bandages</subject><subject>Biocompatibility</subject><subject>Clinical trials</subject><subject>Efficiency</subject><subject>Gels</subject><subject>Glycoproteins</subject><subject>Hospitalization</subject><subject>Hydrogels</subject><subject>Laboratories</subject><subject>Pharmacy</subject><subject>Photochemotherapy</subject><subject>Photodynamic therapy</subject><subject>R&D</subject><subject>Research & development</subject><subject>Skin</subject><subject>Staphylococcus aureus</subject><subject>Trauma</subject><subject>wound dressings</subject><subject>Wounds and Injuries - microbiology</subject><subject>Wounds and Injuries - therapy</subject><issn>1071-7544</issn><issn>1521-0464</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNp9ks1vFCEYhydGY2v1T9BM4sXLVGCAgYuxafxo0sSLnsk7My-zbGZhBabN-tfLdrfVevACBB4ePt5fVb2m5JwSRd5T0tFOcH7OCGOlEUoK8qQ6pYLRhnDJn5ZxYZo9dFK9SGlNCFGUiefVSSvarpWqPa1-XcyT85Cx6SHhWAPGMOGcakj1bVj8WI8RU3J-SrUNsUZr3eDQ57qHIWN0MNcDbPMSsYZCo1-BH_Yin90fZLsKOYw7Dxs31HmFEba7l9UzC3PCV8f-rPrx-dP3y6_N9bcvV5cX183ANcsNKkX1SIQgCEqD7VTLkHaEWNlrJjUINRLKOJVjx7uuL6-kzLaohh4U9LY9q64O3jHA2myj20DcmQDO3E2EOBmI2Q0zGks54RqAIAcOtgikYEx1XHCr5Z3rw8G1XfoNjkP5iAjzI-njFe9WZgo3RhOuNNdF8O4oiOHngimbjUsDzjN4DEsyTHKpeUvVHn37D7oOS_TlqwwrRdVaKskKJQ7UEENKEe3DZSgx-6SY-6SYfVLMMSll35u_X_Kw6z4aBfh4AJwvhd_AbYjzaDLs5hBtLEV2ybT_P-M304TPKg</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>Guo, Ning</creator><creator>Xia, Yu</creator><creator>Zeng, Weishen</creator><creator>Chen, Jia</creator><creator>Wu, Quanxin</creator><creator>Shi, Yaxin</creator><creator>Li, Guoying</creator><creator>Huang, Zhuoyi</creator><creator>Wang, Guanhai</creator><creator>Liu, Yun</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88I</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M2P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PKEHL</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>202212</creationdate><title>Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy</title><author>Guo, Ning ; Xia, Yu ; Zeng, Weishen ; Chen, Jia ; Wu, Quanxin ; Shi, Yaxin ; Li, Guoying ; Huang, Zhuoyi ; Wang, Guanhai ; Liu, Yun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-e8819d0550ea89af7832e1700f6b9269a58d012416d7477b00012f3e8cba8abf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acids</topic><topic>aerogels</topic><topic>Alginate</topic><topic>Alginates - chemistry</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>antibacterial photodynamic therapy</topic><topic>Antibiotics</topic><topic>bacterial capture</topic><topic>Bacterial infections</topic><topic>Bandages</topic><topic>Biocompatibility</topic><topic>Clinical trials</topic><topic>Efficiency</topic><topic>Gels</topic><topic>Glycoproteins</topic><topic>Hospitalization</topic><topic>Hydrogels</topic><topic>Laboratories</topic><topic>Pharmacy</topic><topic>Photochemotherapy</topic><topic>Photodynamic therapy</topic><topic>R&D</topic><topic>Research & development</topic><topic>Skin</topic><topic>Staphylococcus aureus</topic><topic>Trauma</topic><topic>wound dressings</topic><topic>Wounds and Injuries - microbiology</topic><topic>Wounds and Injuries - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guo, Ning</creatorcontrib><creatorcontrib>Xia, Yu</creatorcontrib><creatorcontrib>Zeng, Weishen</creatorcontrib><creatorcontrib>Chen, Jia</creatorcontrib><creatorcontrib>Wu, Quanxin</creatorcontrib><creatorcontrib>Shi, Yaxin</creatorcontrib><creatorcontrib>Li, Guoying</creatorcontrib><creatorcontrib>Huang, Zhuoyi</creatorcontrib><creatorcontrib>Wang, Guanhai</creatorcontrib><creatorcontrib>Liu, Yun</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Drug delivery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Ning</au><au>Xia, Yu</au><au>Zeng, Weishen</au><au>Chen, Jia</au><au>Wu, Quanxin</au><au>Shi, Yaxin</au><au>Li, Guoying</au><au>Huang, Zhuoyi</au><au>Wang, Guanhai</au><au>Liu, Yun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy</atitle><jtitle>Drug delivery</jtitle><addtitle>Drug Deliv</addtitle><date>2022-12</date><risdate>2022</risdate><volume>29</volume><issue>1</issue><spage>1086</spage><epage>1099</epage><pages>1086-1099</pages><issn>1071-7544</issn><eissn>1521-0464</eissn><abstract>The development of novel wound dressings, such as aerogels, with rapid hemostasis and bactericidal capacities for pre-hospital care is necessary. To prevent the occurrence of bacterial resistance, antibacterial photodynamic therapy (aPDT) with broad-spectrum antibacterial ability and negligible bacterial resistance has been intensively studied. However, photosensitizers often suffer from poor water solubility, short singlet oxygen (
1
O
2
) half-life and restricted
1
O
2
diffusion distance. Herein, sodium alginate was covalently modified by photosensitizers and phenylboronic acid, and cross-linked by Ca(II) ions to generate SA@TPAPP@PBA aerogel after lyophilization as an antibacterial photodynamic wound dressing. Afterwards, its photodynamic and bacterial capture activities were intensively evaluated. Furthermore, its hemostasis and bactericidal efficiency against Staphylococcus aureus were assessed via in vitro and in vivo assays. First, chemical immobilization of photosensitizers led to an enhancement of its solubility. Moreover, it showed an excellent hemostasis capacity. Due to the formation of reversible covalent bonds between phenylboronic acid and diol groups on bacterial cell surface, the aerogel could capture S. aureus tightly and dramatically enhance aPDT. To sum up, the prepared aerogel illustrated excellent hemostasis capacity and antibacterial ability against S. aureus. Therefore, they have great potential to be utilized as wound dressing in clinical trials.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>35373683</pmid><doi>10.1080/10717544.2022.2058650</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acids aerogels Alginate Alginates - chemistry Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology antibacterial photodynamic therapy Antibiotics bacterial capture Bacterial infections Bandages Biocompatibility Clinical trials Efficiency Gels Glycoproteins Hospitalization Hydrogels Laboratories Pharmacy Photochemotherapy Photodynamic therapy R&D Research & development Skin Staphylococcus aureus Trauma wound dressings Wounds and Injuries - microbiology Wounds and Injuries - therapy |
| title | Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy |
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