The protection afforded by Berberine against chemotherapy‐mediated nephropathy in rats involves regulation of the antioxidant axis

Doxorubicin (DOX) treatment in cancer patients leads to nephrotoxicity. The nephroprotective effect of Berberine (BBR), a herbal ingredient, is well documented as antioxidant and activation of the Nrf2 signalling. This study aimed to investigate if Nrf2 is a major protective mechanism of BBR in DOX...

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2023-01, Vol.132 (1), p.98-110
Hauptverfasser:	Alagal, Reham I., AlFaris, Nora A., Alshammari, Ghedeir M., ALTamimi, Jozaa Z., AlMousa, Lujain A., Yahya, Mohammed Abdo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antioxidants Antioxidants - metabolism Antioxidants - pharmacology Berberine Berberine - pharmacology Berberine - therapeutic use Caspase Chemotherapy Degeneration Doxorubicin Doxorubicin - toxicity Glutathione Glutathione - metabolism Interleukin 6 Kelch-Like ECH-Associated Protein 1 kidney Kidney Diseases - chemically induced Kidney Diseases - drug therapy Kidneys Lipids Nephropathy NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nrf2 Oxidative Stress Peroxides Rats Reactive oxygen species RNA, Messenger Superoxide dismutase Tumor necrosis factor Tumor necrosis factor-TNF Tumors
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