Genome Mining Enabled by Biosynthetic Characterization Uncovers a Class of Benzoxazolinate‐Containing Natural Products in Diverse Bacteria

Benzoxazolinate is a rare bis‐heterocyclic moiety that interacts with proteins and DNA and confers extraordinary bioactivities on natural products, such as C‐1027. However, the biosynthetic gene responsible for the key cyclization step of benzoxazolinate remains unclear. Herein, we show a putative a...

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Veröffentlicht in:	Angewandte Chemie 2022-12, Vol.134 (51), p.n/a
Hauptverfasser:	Shi, Yi‐Ming, Crames, Jan J., Czech, Laura, Bozhüyük, Kenan A. J., Shi, Yan‐Ni, Hirschmann, Merle, Lamberth, Stefanie, Claus, Peter, Paczia, Nicole, Rückert, Christian, Kalinowski, Jörn, Bange, Gert, Bode, Helge B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Biosynthesis Chemistry Deoxyribonucleic acid DNA Genomes Heterocycles Natural Products Non-Proteinogenic Amino Acids Non-Ribosomal Peptide Synthetase Synergistic effect
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