Sapogenin Levels in Narthecium ossifragum Plants and Ovis aries Lamb Faeces during Two Alveld Outbreaks in Møre og Romsdal, Norway, 2001
The proposal that saponins produced by the lily bog asphodel (Narthecium ossifragum) may be the direct cause of the hepatogenous photosensitization disease alveld seen in Norwegian lambs was investigated by comparing sapogenin levels in two control and two toxic pastures, and in faeces from lambs gr...
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| Veröffentlicht in: | Veterinary research communications 2007-10, Vol.31 (7), p.895-908 |
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| creator | Mysterud, I Flåøyen, A Loader, J. I Wilkins, A. L |
| description | The proposal that saponins produced by the lily bog asphodel (Narthecium ossifragum) may be the direct cause of the hepatogenous photosensitization disease alveld seen in Norwegian lambs was investigated by comparing sapogenin levels in two control and two toxic pastures, and in faeces from lambs grazing the four pastures in the Halsa and Surnadal municipalities, Møre og Romsdal county, Norway. Generally similar levels of sapogenins, determined after hydrolysis of parent plant saponins, were found in Narthecium leaves collected in June/July 2001 from the two alveld outbreak areas and two nearby control areas. Differences in the median sapogenin levels determined for leaf samples in outbreak and control areas were not statistically significant. The total level of free and conjugated sapogenins in faeces recovered from the rectums of lambs grazing the outbreak and control pastures areas varied greatly. The results obtained do not support the hypothesis that a dose-response relationship exists between Narthecium saponin levels and the occurrence of alveld outbreaks. |
| doi_str_mv | 10.1007/s11259-007-3561-z |
| format | Article |
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I ; Wilkins, A. L</creator><creatorcontrib>Mysterud, I ; Flåøyen, A ; Loader, J. I ; Wilkins, A. L</creatorcontrib><description>The proposal that saponins produced by the lily bog asphodel (Narthecium ossifragum) may be the direct cause of the hepatogenous photosensitization disease alveld seen in Norwegian lambs was investigated by comparing sapogenin levels in two control and two toxic pastures, and in faeces from lambs grazing the four pastures in the Halsa and Surnadal municipalities, Møre og Romsdal county, Norway. Generally similar levels of sapogenins, determined after hydrolysis of parent plant saponins, were found in Narthecium leaves collected in June/July 2001 from the two alveld outbreak areas and two nearby control areas. Differences in the median sapogenin levels determined for leaf samples in outbreak and control areas were not statistically significant. The total level of free and conjugated sapogenins in faeces recovered from the rectums of lambs grazing the outbreak and control pastures areas varied greatly. The results obtained do not support the hypothesis that a dose-response relationship exists between Narthecium saponin levels and the occurrence of alveld outbreaks.</description><identifier>ISSN: 0165-7380</identifier><identifier>EISSN: 1573-7446</identifier><identifier>DOI: 10.1007/s11259-007-3561-z</identifier><identifier>PMID: 17279463</identifier><language>eng</language><publisher>Netherlands: Dordrecht : Springer Netherlands</publisher><subject>alveld ; Animals ; bogs ; chemical analysis ; dietary exposure ; Dioscoreaceae - chemistry ; Dioscoreaceae - toxicity ; disease outbreaks ; dose response ; epidemiological studies ; etiology ; feces ; Feces - chemistry ; Gas Chromatography-Mass Spectrometry - methods ; grazing ; lambs ; leaves ; liver diseases ; Magnoliopsida - chemistry ; Magnoliopsida - toxicity ; Narthecium ossifragum ; natural toxicants ; Norway ; photosensitivity disorders ; Photosensitivity Disorders - chemically induced ; Photosensitivity Disorders - veterinary ; Plant Leaves - chemistry ; Plant Leaves - toxicity ; quantitative analysis ; risk assessment ; Sapogenins - analysis ; Sapogenins - toxicity ; saponins ; Sheep ; sheep diseases ; Sheep Diseases - chemically induced ; wetland plants</subject><ispartof>Veterinary research communications, 2007-10, Vol.31 (7), p.895-908</ispartof><rights>Springer Science + Business Media, Inc. 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-d499be2862e9169f7c3c773c7b0f690e4b1ddffe89e52e46a2953692224ca39c3</citedby><cites>FETCH-LOGICAL-c350t-d499be2862e9169f7c3c773c7b0f690e4b1ddffe89e52e46a2953692224ca39c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17279463$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mysterud, I</creatorcontrib><creatorcontrib>Flåøyen, A</creatorcontrib><creatorcontrib>Loader, J. I</creatorcontrib><creatorcontrib>Wilkins, A. L</creatorcontrib><title>Sapogenin Levels in Narthecium ossifragum Plants and Ovis aries Lamb Faeces during Two Alveld Outbreaks in Møre og Romsdal, Norway, 2001</title><title>Veterinary research communications</title><addtitle>Vet Res Commun</addtitle><description>The proposal that saponins produced by the lily bog asphodel (Narthecium ossifragum) may be the direct cause of the hepatogenous photosensitization disease alveld seen in Norwegian lambs was investigated by comparing sapogenin levels in two control and two toxic pastures, and in faeces from lambs grazing the four pastures in the Halsa and Surnadal municipalities, Møre og Romsdal county, Norway. Generally similar levels of sapogenins, determined after hydrolysis of parent plant saponins, were found in Narthecium leaves collected in June/July 2001 from the two alveld outbreak areas and two nearby control areas. Differences in the median sapogenin levels determined for leaf samples in outbreak and control areas were not statistically significant. The total level of free and conjugated sapogenins in faeces recovered from the rectums of lambs grazing the outbreak and control pastures areas varied greatly. The results obtained do not support the hypothesis that a dose-response relationship exists between Narthecium saponin levels and the occurrence of alveld outbreaks.</description><subject>alveld</subject><subject>Animals</subject><subject>bogs</subject><subject>chemical analysis</subject><subject>dietary exposure</subject><subject>Dioscoreaceae - chemistry</subject><subject>Dioscoreaceae - toxicity</subject><subject>disease outbreaks</subject><subject>dose response</subject><subject>epidemiological studies</subject><subject>etiology</subject><subject>feces</subject><subject>Feces - chemistry</subject><subject>Gas Chromatography-Mass Spectrometry - methods</subject><subject>grazing</subject><subject>lambs</subject><subject>leaves</subject><subject>liver diseases</subject><subject>Magnoliopsida - chemistry</subject><subject>Magnoliopsida - toxicity</subject><subject>Narthecium ossifragum</subject><subject>natural toxicants</subject><subject>Norway</subject><subject>photosensitivity disorders</subject><subject>Photosensitivity Disorders - chemically induced</subject><subject>Photosensitivity Disorders - veterinary</subject><subject>Plant Leaves - chemistry</subject><subject>Plant Leaves - toxicity</subject><subject>quantitative analysis</subject><subject>risk assessment</subject><subject>Sapogenins - analysis</subject><subject>Sapogenins - toxicity</subject><subject>saponins</subject><subject>Sheep</subject><subject>sheep diseases</subject><subject>Sheep Diseases - chemically induced</subject><subject>wetland plants</subject><issn>0165-7380</issn><issn>1573-7446</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpFkcFO3DAQhi1UBFvgAXqhVs-Eju3Ejo9oVdpKC1QFzpaTTNJAEi92soh9g74Rd16sXnalHkb-Dv98I_0m5BODcwagvgbGeKaTiInIJEvWe2TGMiUSlabyA5kBk1miRA6H5GMIDwCgcxAH5JAprnQqxYz8vbVL1-DQDnSBK-wCjXRt_fgHy3bqqQuhrb1tIv7q7DAGaoeK3qzaCL7FQBe2L-ilxTJyNfl2aOjds6MXXZTF4DQWHu3ju_bq7dUjdQ397fpQ2e6MXjv_bF_OKAdgx2S_tl3Ak917RO4vv93NfySLm-8_5xeLpBQZjEmVal0gzyVHzaSuVSlKpeIUUEsNmBasquoac40Zx1RarjMhNec8La3QpTgiX7bepXdPE4bRPLjJD_Gk4SoDyYSSMcS2odLHBjzWZunb3voXw8Bsujfb7s0GN92bddw53Ymnosfq_8au7Bj4vA3U1hnb-DaY-1sOTERJLlX8uH_vGIkn</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Mysterud, I</creator><creator>Flåøyen, A</creator><creator>Loader, J. 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L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-d499be2862e9169f7c3c773c7b0f690e4b1ddffe89e52e46a2953692224ca39c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>alveld</topic><topic>Animals</topic><topic>bogs</topic><topic>chemical analysis</topic><topic>dietary exposure</topic><topic>Dioscoreaceae - chemistry</topic><topic>Dioscoreaceae - toxicity</topic><topic>disease outbreaks</topic><topic>dose response</topic><topic>epidemiological studies</topic><topic>etiology</topic><topic>feces</topic><topic>Feces - chemistry</topic><topic>Gas Chromatography-Mass Spectrometry - methods</topic><topic>grazing</topic><topic>lambs</topic><topic>leaves</topic><topic>liver diseases</topic><topic>Magnoliopsida - chemistry</topic><topic>Magnoliopsida - toxicity</topic><topic>Narthecium ossifragum</topic><topic>natural toxicants</topic><topic>Norway</topic><topic>photosensitivity disorders</topic><topic>Photosensitivity Disorders - chemically induced</topic><topic>Photosensitivity Disorders - veterinary</topic><topic>Plant Leaves - chemistry</topic><topic>Plant Leaves - toxicity</topic><topic>quantitative analysis</topic><topic>risk assessment</topic><topic>Sapogenins - analysis</topic><topic>Sapogenins - toxicity</topic><topic>saponins</topic><topic>Sheep</topic><topic>sheep diseases</topic><topic>Sheep Diseases - chemically induced</topic><topic>wetland plants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mysterud, I</creatorcontrib><creatorcontrib>Flåøyen, A</creatorcontrib><creatorcontrib>Loader, J. 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I</au><au>Wilkins, A. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sapogenin Levels in Narthecium ossifragum Plants and Ovis aries Lamb Faeces during Two Alveld Outbreaks in Møre og Romsdal, Norway, 2001</atitle><jtitle>Veterinary research communications</jtitle><addtitle>Vet Res Commun</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>31</volume><issue>7</issue><spage>895</spage><epage>908</epage><pages>895-908</pages><issn>0165-7380</issn><eissn>1573-7446</eissn><abstract>The proposal that saponins produced by the lily bog asphodel (Narthecium ossifragum) may be the direct cause of the hepatogenous photosensitization disease alveld seen in Norwegian lambs was investigated by comparing sapogenin levels in two control and two toxic pastures, and in faeces from lambs grazing the four pastures in the Halsa and Surnadal municipalities, Møre og Romsdal county, Norway. Generally similar levels of sapogenins, determined after hydrolysis of parent plant saponins, were found in Narthecium leaves collected in June/July 2001 from the two alveld outbreak areas and two nearby control areas. Differences in the median sapogenin levels determined for leaf samples in outbreak and control areas were not statistically significant. The total level of free and conjugated sapogenins in faeces recovered from the rectums of lambs grazing the outbreak and control pastures areas varied greatly. The results obtained do not support the hypothesis that a dose-response relationship exists between Narthecium saponin levels and the occurrence of alveld outbreaks.</abstract><cop>Netherlands</cop><pub>Dordrecht : Springer Netherlands</pub><pmid>17279463</pmid><doi>10.1007/s11259-007-3561-z</doi><tpages>14</tpages></addata></record> |
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| ispartof | Veterinary research communications, 2007-10, Vol.31 (7), p.895-908 |
| issn | 0165-7380 1573-7446 |
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| subjects | alveld Animals bogs chemical analysis dietary exposure Dioscoreaceae - chemistry Dioscoreaceae - toxicity disease outbreaks dose response epidemiological studies etiology feces Feces - chemistry Gas Chromatography-Mass Spectrometry - methods grazing lambs leaves liver diseases Magnoliopsida - chemistry Magnoliopsida - toxicity Narthecium ossifragum natural toxicants Norway photosensitivity disorders Photosensitivity Disorders - chemically induced Photosensitivity Disorders - veterinary Plant Leaves - chemistry Plant Leaves - toxicity quantitative analysis risk assessment Sapogenins - analysis Sapogenins - toxicity saponins Sheep sheep diseases Sheep Diseases - chemically induced wetland plants |
| title | Sapogenin Levels in Narthecium ossifragum Plants and Ovis aries Lamb Faeces during Two Alveld Outbreaks in Møre og Romsdal, Norway, 2001 |
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