Ruminal metabolism in sheep of saponins from Yucca schidigera
Fifty-five mg per kg live weight of crystallized Yucca schidigera saponins, corresponding to 26 mg/kg live weight of sapogenins, was given daily intraruminally to two lambs for 11 consecutive days. Neither of the lambs showed any sign of toxicity throughout the experimental period. One lamb was kill...
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| Veröffentlicht in: | Veterinary research communications 2002-03, Vol.26 (2), p.159 |
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| creator | Flåøyen, A Wilkins, A L Sandvik, M |
| description | Fifty-five mg per kg live weight of crystallized Yucca schidigera saponins, corresponding to 26 mg/kg live weight of sapogenins, was given daily intraruminally to two lambs for 11 consecutive days. Neither of the lambs showed any sign of toxicity throughout the experimental period. One lamb was killed 5 h after the last dose and GC-MS analysis of the free and conjugated sapogenin content samples of liver, and of the contents of the rumen, omasum, abomasum, duodenum, jejunum, ileum, colon and rectum, of faecal samples collected before dosing started, and of parts of the administered Yucca saponin were performed. The Yucca material contained mainly sarsasapogenin and smilagenin saponins. Ingested saponins were quickly hydrolysed in the rumen to free sapogenins and, in part, epimerized at C-3 to afford episapogenins. The absorption of free sapogenins appeared to occur in the jejunum. The metabolism of Yucca saponins was identical to that of Narthecium ossifragum saponins, and it is suggested that Yucca saponins could replace N. ossifragum saponins for toxicity studies on the latter plant. |
| doi_str_mv | 10.1023/A:1014051803104 |
| format | Article |
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Neither of the lambs showed any sign of toxicity throughout the experimental period. One lamb was killed 5 h after the last dose and GC-MS analysis of the free and conjugated sapogenin content samples of liver, and of the contents of the rumen, omasum, abomasum, duodenum, jejunum, ileum, colon and rectum, of faecal samples collected before dosing started, and of parts of the administered Yucca saponin were performed. The Yucca material contained mainly sarsasapogenin and smilagenin saponins. Ingested saponins were quickly hydrolysed in the rumen to free sapogenins and, in part, epimerized at C-3 to afford episapogenins. The absorption of free sapogenins appeared to occur in the jejunum. The metabolism of Yucca saponins was identical to that of Narthecium ossifragum saponins, and it is suggested that Yucca saponins could replace N. ossifragum saponins for toxicity studies on the latter plant.</description><identifier>ISSN: 0165-7380</identifier><identifier>EISSN: 1573-7446</identifier><identifier>DOI: 10.1023/A:1014051803104</identifier><identifier>PMID: 11922485</identifier><language>eng</language><publisher>Netherlands: Springer Nature B.V</publisher><subject>Animals ; Digestive System - drug effects ; Digestive System - metabolism ; Female ; Intestinal Absorption ; Male ; Molecular Structure ; Photosensitivity Disorders ; Plants, Toxic ; Saponins - administration & dosage ; Saponins - metabolism ; Saponins - pharmacokinetics ; Saponins - toxicity ; Sheep - metabolism ; Toxicity Tests - methods ; Yucca</subject><ispartof>Veterinary research communications, 2002-03, Vol.26 (2), p.159</ispartof><rights>Copyright (c) 2002 Kluwer Academic Publishers</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11922485$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Flåøyen, A</creatorcontrib><creatorcontrib>Wilkins, A L</creatorcontrib><creatorcontrib>Sandvik, M</creatorcontrib><title>Ruminal metabolism in sheep of saponins from Yucca schidigera</title><title>Veterinary research communications</title><addtitle>Vet Res Commun</addtitle><description>Fifty-five mg per kg live weight of crystallized Yucca schidigera saponins, corresponding to 26 mg/kg live weight of sapogenins, was given daily intraruminally to two lambs for 11 consecutive days. 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The metabolism of Yucca saponins was identical to that of Narthecium ossifragum saponins, and it is suggested that Yucca saponins could replace N. ossifragum saponins for toxicity studies on the latter plant.</description><subject>Animals</subject><subject>Digestive System - drug effects</subject><subject>Digestive System - metabolism</subject><subject>Female</subject><subject>Intestinal Absorption</subject><subject>Male</subject><subject>Molecular Structure</subject><subject>Photosensitivity Disorders</subject><subject>Plants, Toxic</subject><subject>Saponins - administration & dosage</subject><subject>Saponins - metabolism</subject><subject>Saponins - pharmacokinetics</subject><subject>Saponins - toxicity</subject><subject>Sheep - metabolism</subject><subject>Toxicity Tests - methods</subject><subject>Yucca</subject><issn>0165-7380</issn><issn>1573-7446</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNo1jztPwzAUhS0EoqUwsyGLPXCv7dgJEkNV8ZIqISEYmCLHvqGumgdxMvTfE0SZznA-nQdjlwg3CELeLu8QUEGKGUgEdcTmmBqZGKX0MZsD6jQxMoMZO4txCwD5xJ2yGWIuhMrSObt_G-vQ2B2vabBluwux5qHhcUPU8bbi0XZtE5rIq76t-efonOXRbYIPX9Tbc3ZS2V2ki4Mu2Mfjw_vqOVm_Pr2sluukE1INiXL2t7rMBVihNXhDIqPSOuGqEtARkUEvqJTaa5VVxk--wmmhl5lQJBfs-i-369vvkeJQbNuxn2bHQhiVm1QoPUFXB2gsa_JF14fa9vvi_6z8AaW5VWY</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Flåøyen, A</creator><creator>Wilkins, A L</creator><creator>Sandvik, M</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20020301</creationdate><title>Ruminal metabolism in sheep of saponins from Yucca schidigera</title><author>Flåøyen, A ; Wilkins, A L ; Sandvik, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p234t-4ca0098b920a2660d7e28ebac2cfb01ceee71d2eb36d648f7de2841248d3824e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Digestive System - drug effects</topic><topic>Digestive System - metabolism</topic><topic>Female</topic><topic>Intestinal Absorption</topic><topic>Male</topic><topic>Molecular Structure</topic><topic>Photosensitivity Disorders</topic><topic>Plants, Toxic</topic><topic>Saponins - administration & dosage</topic><topic>Saponins - metabolism</topic><topic>Saponins - pharmacokinetics</topic><topic>Saponins - toxicity</topic><topic>Sheep - metabolism</topic><topic>Toxicity Tests - methods</topic><topic>Yucca</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Flåøyen, A</creatorcontrib><creatorcontrib>Wilkins, A L</creatorcontrib><creatorcontrib>Sandvik, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Veterinary research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Flåøyen, A</au><au>Wilkins, A L</au><au>Sandvik, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ruminal metabolism in sheep of saponins from Yucca schidigera</atitle><jtitle>Veterinary research communications</jtitle><addtitle>Vet Res Commun</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>26</volume><issue>2</issue><spage>159</spage><pages>159-</pages><issn>0165-7380</issn><eissn>1573-7446</eissn><abstract>Fifty-five mg per kg live weight of crystallized Yucca schidigera saponins, corresponding to 26 mg/kg live weight of sapogenins, was given daily intraruminally to two lambs for 11 consecutive days. Neither of the lambs showed any sign of toxicity throughout the experimental period. One lamb was killed 5 h after the last dose and GC-MS analysis of the free and conjugated sapogenin content samples of liver, and of the contents of the rumen, omasum, abomasum, duodenum, jejunum, ileum, colon and rectum, of faecal samples collected before dosing started, and of parts of the administered Yucca saponin were performed. The Yucca material contained mainly sarsasapogenin and smilagenin saponins. Ingested saponins were quickly hydrolysed in the rumen to free sapogenins and, in part, epimerized at C-3 to afford episapogenins. The absorption of free sapogenins appeared to occur in the jejunum. The metabolism of Yucca saponins was identical to that of Narthecium ossifragum saponins, and it is suggested that Yucca saponins could replace N. ossifragum saponins for toxicity studies on the latter plant.</abstract><cop>Netherlands</cop><pub>Springer Nature B.V</pub><pmid>11922485</pmid><doi>10.1023/A:1014051803104</doi></addata></record> |
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| subjects | Animals Digestive System - drug effects Digestive System - metabolism Female Intestinal Absorption Male Molecular Structure Photosensitivity Disorders Plants, Toxic Saponins - administration & dosage Saponins - metabolism Saponins - pharmacokinetics Saponins - toxicity Sheep - metabolism Toxicity Tests - methods Yucca |
| title | Ruminal metabolism in sheep of saponins from Yucca schidigera |
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