Investigating Drug-Induced QT and QTc Prolongation in the Clinic: A Review of Statistical Design and Analysis Considerations: Report from the Pharmaceutical Research and Manufacturers of America QT Statistics Expert Team

The dangers inherent to the public via the use of drugs known to prolong the QT and QTc interval such as terfenadine and cisapride call for a careful evaluation of this potential in drug development. Methods in development for this assessment in preclinical and clinical development are reviewed, and...

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Veröffentlicht in:	Drug information journal 2005-07, Vol.39 (3), p.243-265
1. Verfasser:	Patterson, Scott D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Clinical trials Design analysis Drug development Prolongation Statistical analysis Statistics Terfenadine
Online-Zugang:	Volltext
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