A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses

The repeated emergence of highly pathogenic human coronaviruses as well as their evolving variants highlight the need to develop potent and broad-spectrum antiviral therapeutics and vaccines. By screening monoclonal antibodies (mAbs) isolated from COVID-19-convalescent patients, we found one mAb, 2-...

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Veröffentlicht in:	Emerging microbes & infections 2022-12, Vol.11 (1), p.147-157
Hauptverfasser:	Wang, Pengfei, Casner, Ryan G., Nair, Manoj S., Yu, Jian, Guo, Yicheng, Wang, Maple, Chan, Jasper F.-W., Cerutti, Gabriele, Iketani, Sho, Liu, Lihong, Sheng, Zizhang, Chen, Zhiwei, Yuen, Kwok-Yung, Kwong, Peter D., Huang, Yaoxing, Shapiro, Lawrence, Ho, David D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Antibodies, Neutralizing - immunology Antibodies, Viral - immunology antibody Broadly Neutralizing Antibodies - immunology Chlorocebus aethiops Coronaviruses COVID-19 Cryoelectron Microscopy Epitopes - immunology HEK293 Cells Humans Infectious diseases Mutation Neutralization Tests Protein Interaction Domains and Motifs Protein Structure, Tertiary sarbecovirus SARS-CoV SARS-CoV-2 SARS-CoV-2 - immunology Severe acute respiratory syndrome coronavirus 2 variants Vero Cells Viruses
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