The synergetic effect of a gold nanocluster-calcium phosphate composite: enhanced photoluminescence intensity and superior bioactivity
Gold nanoclusters (AuNCs) are a unique class of materials that exhibit visible luminescence. Amorphous calcium phosphate (ACP) is a widely used biomaterial for a variety of purposes, such as drug delivery, bone cementing, and implant coatings. In this study, a nanocomposite of AuNCs and ACP is prepa...
Gespeichert in:
| Veröffentlicht in: | Physical chemistry chemical physics : PCCP 2022-12, Vol.24 (47), p.2934-2942 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2942 |
|---|---|
| container_issue | 47 |
| container_start_page | 2934 |
| container_title | Physical chemistry chemical physics : PCCP |
| container_volume | 24 |
| creator | Jiang, Yingying Chen, Xin Yang, Jingzhi Chang, Lo-Yueh Chan, Ting-Shan Liu, Han Zhu, Xiaohui Su, Jiacan Zhang, Hao Fan, Yunshan Liu, Lijia |
| description | Gold nanoclusters (AuNCs) are a unique class of materials that exhibit visible luminescence. Amorphous calcium phosphate (ACP) is a widely used biomaterial for a variety of purposes, such as drug delivery, bone cementing, and implant coatings. In this study, a nanocomposite of AuNCs and ACP is prepared by biomimetic mineralization in a Dulbecco's modified Eagle's medium (DMEM). The strong interaction between AuNCs and Ca
2+
ions effectively induces aggregation of AuNCs. The as-formed nanocomposite, AuNCs@ACP, emits significantly enhanced luminescence compared to AuNCs alone. The luminescence enhancement mechanism is investigated using synchrotron X-ray absorption fine structure spectroscopy. In addition, the presence of AuNCs stabilizes ACP and also enhances the biocompatibility of ACP in promoting cell proliferation, and the nanocomposites are promising as nanoprobes for cancer therapy and/or bone tissue engineering.
Gold nanoclusters (AuNCs) loaded on calcium phosphate (Ca-P) through biomimetic mineralization show bright luminescence through aggregation induced emission enhancement and the as-formed composite has greater biocompatibility than AuNCs or Ca-P alone. |
| doi_str_mv | 10.1039/d2cp04222c |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2747783673</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2740511497</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-e20598dae16a443ae0acd0dfa081dd653f54322cba2656df5bc4783b02cdcd943</originalsourceid><addsrcrecordid>eNpd0ctq3DAUBmAREnLfZN8iyKYU3Ohme9xdmaZtINAskrWRj44zCrbkSHJhXiDPXU0mmUJXEvo_Dgf9hFxw9oUz2VwZARNTQgjYI8dcVbJo2ELt7-51dUROYnxijPGSy0NyJCslaqbUMXm5XyGNa4fhEZMFin2PkKjvqaaPfjDUaedhmGPCUIAewM4jnVY-TiudkIIfJx9twq8U3Uo7QLNJkx_m0TqMgPmJWpfQZbWm2hka5wmD9YF21mtI9k8OzshBr4eI52_nKXn4cX2__FXc_v55s_x2W4CUdSpQsLJZGI280kpJjUyDYabXbMGNqUrZl0rmf-i0qMrK9GUHql7IjgkwYBolT8mn7dwp-OcZY2pHm5ccBu3Qz7EVtWIl56qpM738jz75Obi83UbVeWxVy6w-bxUEH2PAvp2CHXVYt5y1m3ba72J599rOMuOPbyPnbkSzo-91ZPBhC0KEXfqvXvkXkJmXXA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2747783673</pqid></control><display><type>article</type><title>The synergetic effect of a gold nanocluster-calcium phosphate composite: enhanced photoluminescence intensity and superior bioactivity</title><source>Royal Society of Chemistry Free Journals plus Gold OA Content</source><source>Alma/SFX Local Collection</source><creator>Jiang, Yingying ; Chen, Xin ; Yang, Jingzhi ; Chang, Lo-Yueh ; Chan, Ting-Shan ; Liu, Han ; Zhu, Xiaohui ; Su, Jiacan ; Zhang, Hao ; Fan, Yunshan ; Liu, Lijia</creator><creatorcontrib>Jiang, Yingying ; Chen, Xin ; Yang, Jingzhi ; Chang, Lo-Yueh ; Chan, Ting-Shan ; Liu, Han ; Zhu, Xiaohui ; Su, Jiacan ; Zhang, Hao ; Fan, Yunshan ; Liu, Lijia</creatorcontrib><description>Gold nanoclusters (AuNCs) are a unique class of materials that exhibit visible luminescence. Amorphous calcium phosphate (ACP) is a widely used biomaterial for a variety of purposes, such as drug delivery, bone cementing, and implant coatings. In this study, a nanocomposite of AuNCs and ACP is prepared by biomimetic mineralization in a Dulbecco's modified Eagle's medium (DMEM). The strong interaction between AuNCs and Ca
2+
ions effectively induces aggregation of AuNCs. The as-formed nanocomposite, AuNCs@ACP, emits significantly enhanced luminescence compared to AuNCs alone. The luminescence enhancement mechanism is investigated using synchrotron X-ray absorption fine structure spectroscopy. In addition, the presence of AuNCs stabilizes ACP and also enhances the biocompatibility of ACP in promoting cell proliferation, and the nanocomposites are promising as nanoprobes for cancer therapy and/or bone tissue engineering.
Gold nanoclusters (AuNCs) loaded on calcium phosphate (Ca-P) through biomimetic mineralization show bright luminescence through aggregation induced emission enhancement and the as-formed composite has greater biocompatibility than AuNCs or Ca-P alone.</description><identifier>ISSN: 1463-9076</identifier><identifier>EISSN: 1463-9084</identifier><identifier>DOI: 10.1039/d2cp04222c</identifier><identifier>PMID: 36427044</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Amorphous materials ; Biocompatibility ; Biomedical materials ; Biomimetics ; Calcium ions ; Calcium phosphates ; Cementing ; Fine structure ; Gold ; Luminescence ; Nanoclusters ; Nanocomposites ; Photoluminescence ; Strong interactions (field theory) ; Surgical implants ; Synchrotron radiation ; Synchrotrons ; Tissue engineering ; X ray absorption</subject><ispartof>Physical chemistry chemical physics : PCCP, 2022-12, Vol.24 (47), p.2934-2942</ispartof><rights>Copyright Royal Society of Chemistry 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-e20598dae16a443ae0acd0dfa081dd653f54322cba2656df5bc4783b02cdcd943</citedby><cites>FETCH-LOGICAL-c337t-e20598dae16a443ae0acd0dfa081dd653f54322cba2656df5bc4783b02cdcd943</cites><orcidid>0000-0003-2439-0739 ; 0000-0002-0788-8546 ; 0000-0003-2815-5197</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36427044$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Yingying</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Yang, Jingzhi</creatorcontrib><creatorcontrib>Chang, Lo-Yueh</creatorcontrib><creatorcontrib>Chan, Ting-Shan</creatorcontrib><creatorcontrib>Liu, Han</creatorcontrib><creatorcontrib>Zhu, Xiaohui</creatorcontrib><creatorcontrib>Su, Jiacan</creatorcontrib><creatorcontrib>Zhang, Hao</creatorcontrib><creatorcontrib>Fan, Yunshan</creatorcontrib><creatorcontrib>Liu, Lijia</creatorcontrib><title>The synergetic effect of a gold nanocluster-calcium phosphate composite: enhanced photoluminescence intensity and superior bioactivity</title><title>Physical chemistry chemical physics : PCCP</title><addtitle>Phys Chem Chem Phys</addtitle><description>Gold nanoclusters (AuNCs) are a unique class of materials that exhibit visible luminescence. Amorphous calcium phosphate (ACP) is a widely used biomaterial for a variety of purposes, such as drug delivery, bone cementing, and implant coatings. In this study, a nanocomposite of AuNCs and ACP is prepared by biomimetic mineralization in a Dulbecco's modified Eagle's medium (DMEM). The strong interaction between AuNCs and Ca
2+
ions effectively induces aggregation of AuNCs. The as-formed nanocomposite, AuNCs@ACP, emits significantly enhanced luminescence compared to AuNCs alone. The luminescence enhancement mechanism is investigated using synchrotron X-ray absorption fine structure spectroscopy. In addition, the presence of AuNCs stabilizes ACP and also enhances the biocompatibility of ACP in promoting cell proliferation, and the nanocomposites are promising as nanoprobes for cancer therapy and/or bone tissue engineering.
Gold nanoclusters (AuNCs) loaded on calcium phosphate (Ca-P) through biomimetic mineralization show bright luminescence through aggregation induced emission enhancement and the as-formed composite has greater biocompatibility than AuNCs or Ca-P alone.</description><subject>Amorphous materials</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Biomimetics</subject><subject>Calcium ions</subject><subject>Calcium phosphates</subject><subject>Cementing</subject><subject>Fine structure</subject><subject>Gold</subject><subject>Luminescence</subject><subject>Nanoclusters</subject><subject>Nanocomposites</subject><subject>Photoluminescence</subject><subject>Strong interactions (field theory)</subject><subject>Surgical implants</subject><subject>Synchrotron radiation</subject><subject>Synchrotrons</subject><subject>Tissue engineering</subject><subject>X ray absorption</subject><issn>1463-9076</issn><issn>1463-9084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpd0ctq3DAUBmAREnLfZN8iyKYU3Ohme9xdmaZtINAskrWRj44zCrbkSHJhXiDPXU0mmUJXEvo_Dgf9hFxw9oUz2VwZARNTQgjYI8dcVbJo2ELt7-51dUROYnxijPGSy0NyJCslaqbUMXm5XyGNa4fhEZMFin2PkKjvqaaPfjDUaedhmGPCUIAewM4jnVY-TiudkIIfJx9twq8U3Uo7QLNJkx_m0TqMgPmJWpfQZbWm2hka5wmD9YF21mtI9k8OzshBr4eI52_nKXn4cX2__FXc_v55s_x2W4CUdSpQsLJZGI280kpJjUyDYabXbMGNqUrZl0rmf-i0qMrK9GUHql7IjgkwYBolT8mn7dwp-OcZY2pHm5ccBu3Qz7EVtWIl56qpM738jz75Obi83UbVeWxVy6w-bxUEH2PAvp2CHXVYt5y1m3ba72J599rOMuOPbyPnbkSzo-91ZPBhC0KEXfqvXvkXkJmXXA</recordid><startdate>20221207</startdate><enddate>20221207</enddate><creator>Jiang, Yingying</creator><creator>Chen, Xin</creator><creator>Yang, Jingzhi</creator><creator>Chang, Lo-Yueh</creator><creator>Chan, Ting-Shan</creator><creator>Liu, Han</creator><creator>Zhu, Xiaohui</creator><creator>Su, Jiacan</creator><creator>Zhang, Hao</creator><creator>Fan, Yunshan</creator><creator>Liu, Lijia</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2439-0739</orcidid><orcidid>https://orcid.org/0000-0002-0788-8546</orcidid><orcidid>https://orcid.org/0000-0003-2815-5197</orcidid></search><sort><creationdate>20221207</creationdate><title>The synergetic effect of a gold nanocluster-calcium phosphate composite: enhanced photoluminescence intensity and superior bioactivity</title><author>Jiang, Yingying ; Chen, Xin ; Yang, Jingzhi ; Chang, Lo-Yueh ; Chan, Ting-Shan ; Liu, Han ; Zhu, Xiaohui ; Su, Jiacan ; Zhang, Hao ; Fan, Yunshan ; Liu, Lijia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-e20598dae16a443ae0acd0dfa081dd653f54322cba2656df5bc4783b02cdcd943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Amorphous materials</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Biomimetics</topic><topic>Calcium ions</topic><topic>Calcium phosphates</topic><topic>Cementing</topic><topic>Fine structure</topic><topic>Gold</topic><topic>Luminescence</topic><topic>Nanoclusters</topic><topic>Nanocomposites</topic><topic>Photoluminescence</topic><topic>Strong interactions (field theory)</topic><topic>Surgical implants</topic><topic>Synchrotron radiation</topic><topic>Synchrotrons</topic><topic>Tissue engineering</topic><topic>X ray absorption</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Yingying</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Yang, Jingzhi</creatorcontrib><creatorcontrib>Chang, Lo-Yueh</creatorcontrib><creatorcontrib>Chan, Ting-Shan</creatorcontrib><creatorcontrib>Liu, Han</creatorcontrib><creatorcontrib>Zhu, Xiaohui</creatorcontrib><creatorcontrib>Su, Jiacan</creatorcontrib><creatorcontrib>Zhang, Hao</creatorcontrib><creatorcontrib>Fan, Yunshan</creatorcontrib><creatorcontrib>Liu, Lijia</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Physical chemistry chemical physics : PCCP</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Yingying</au><au>Chen, Xin</au><au>Yang, Jingzhi</au><au>Chang, Lo-Yueh</au><au>Chan, Ting-Shan</au><au>Liu, Han</au><au>Zhu, Xiaohui</au><au>Su, Jiacan</au><au>Zhang, Hao</au><au>Fan, Yunshan</au><au>Liu, Lijia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The synergetic effect of a gold nanocluster-calcium phosphate composite: enhanced photoluminescence intensity and superior bioactivity</atitle><jtitle>Physical chemistry chemical physics : PCCP</jtitle><addtitle>Phys Chem Chem Phys</addtitle><date>2022-12-07</date><risdate>2022</risdate><volume>24</volume><issue>47</issue><spage>2934</spage><epage>2942</epage><pages>2934-2942</pages><issn>1463-9076</issn><eissn>1463-9084</eissn><abstract>Gold nanoclusters (AuNCs) are a unique class of materials that exhibit visible luminescence. Amorphous calcium phosphate (ACP) is a widely used biomaterial for a variety of purposes, such as drug delivery, bone cementing, and implant coatings. In this study, a nanocomposite of AuNCs and ACP is prepared by biomimetic mineralization in a Dulbecco's modified Eagle's medium (DMEM). The strong interaction between AuNCs and Ca
2+
ions effectively induces aggregation of AuNCs. The as-formed nanocomposite, AuNCs@ACP, emits significantly enhanced luminescence compared to AuNCs alone. The luminescence enhancement mechanism is investigated using synchrotron X-ray absorption fine structure spectroscopy. In addition, the presence of AuNCs stabilizes ACP and also enhances the biocompatibility of ACP in promoting cell proliferation, and the nanocomposites are promising as nanoprobes for cancer therapy and/or bone tissue engineering.
Gold nanoclusters (AuNCs) loaded on calcium phosphate (Ca-P) through biomimetic mineralization show bright luminescence through aggregation induced emission enhancement and the as-formed composite has greater biocompatibility than AuNCs or Ca-P alone.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>36427044</pmid><doi>10.1039/d2cp04222c</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2439-0739</orcidid><orcidid>https://orcid.org/0000-0002-0788-8546</orcidid><orcidid>https://orcid.org/0000-0003-2815-5197</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1463-9076 |
| ispartof | Physical chemistry chemical physics : PCCP, 2022-12, Vol.24 (47), p.2934-2942 |
| issn | 1463-9076 1463-9084 |
| language | eng |
| recordid | cdi_proquest_journals_2747783673 |
| source | Royal Society of Chemistry Free Journals plus Gold OA Content; Alma/SFX Local Collection |
| subjects | Amorphous materials Biocompatibility Biomedical materials Biomimetics Calcium ions Calcium phosphates Cementing Fine structure Gold Luminescence Nanoclusters Nanocomposites Photoluminescence Strong interactions (field theory) Surgical implants Synchrotron radiation Synchrotrons Tissue engineering X ray absorption |
| title | The synergetic effect of a gold nanocluster-calcium phosphate composite: enhanced photoluminescence intensity and superior bioactivity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T09%3A15%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20synergetic%20effect%20of%20a%20gold%20nanocluster-calcium%20phosphate%20composite:%20enhanced%20photoluminescence%20intensity%20and%20superior%20bioactivity&rft.jtitle=Physical%20chemistry%20chemical%20physics%20:%20PCCP&rft.au=Jiang,%20Yingying&rft.date=2022-12-07&rft.volume=24&rft.issue=47&rft.spage=2934&rft.epage=2942&rft.pages=2934-2942&rft.issn=1463-9076&rft.eissn=1463-9084&rft_id=info:doi/10.1039/d2cp04222c&rft_dat=%3Cproquest_cross%3E2740511497%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2747783673&rft_id=info:pmid/36427044&rfr_iscdi=true |