Clerodane diterpenoids with anti-inflammatory and synergistic antibacterial activities from Tinospora crispa

Ten new and four known clerodane diterpenoids were isolated from the vine and leaves of Tinospora crispa . The chemical structures and absolute stereochemical configurations of all the compounds were established by spectroscopic methods and single-crystal X-ray diffraction analysis combined with ele...

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Veröffentlicht in:	Organic Chemistry Frontiers 2022-12, Vol.9 (24), p.6945-6957
Hauptverfasser:	Zhu, Yang-Li, Deng, Li, Song, Jia-Qi, Zhu, Yan, Yuan, Rong-Wen, Fan, Xian-Zhe, Zhou, Hong, Huang, Ya-Si, Zhang, Li-Jun, Liao, Hai-Bing
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial activity Circular dichroism Crystals Cytotoxicity Dichroism Diterpenes Drug resistance Inflammation Lipopolysaccharides Methicillin Minimum inhibitory concentration Minocycline Nitric oxide Organic chemistry Oxacillin Single crystals Staphylococcus aureus Staphylococcus infections Synergism Toxicity X-ray diffraction
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