Anti-neuroinflammatory Effects and Brain Pharmacokinetic Properties of Selonsertib, an Apoptosis signal-regulating Kinase 1 Inhibitor, in mice

Selonsertib is a first-in-class apoptosis signal-regulating kinase 1 (ASK1) inhibitor in clinical trials for treating NASH and diabetic kidney disease due to its anti-inflammatory and anti-fibrotic activities. In the present study, we investigated the anti-neuroinflammatory effects and brain pharmac...

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Veröffentlicht in:	Neurochemical research 2022-12, Vol.47 (12), p.3829-3837
Hauptverfasser:	Lee, Ji Hun, Ji, Sang Hee, Lim, Jong Seung, Ahn, Sunjoo, Yun, Hwi-yeol, Kim, Seong Hwan, Song, Jin Sook
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Bioavailability Biochemistry Biomedical and Life Sciences Biomedicine Brain Brain - metabolism Caco-2 Cells Cell Biology Central nervous system Chemical compounds Clinical trials Cytokines Diabetes mellitus Efflux Enzyme inhibitors In vivo methods and tests Inflammation Kidney diseases Kinases Lipopolysaccharides Lipopolysaccharides - pharmacology MAP kinase MAP Kinase Kinase Kinase 5 - metabolism MAP Kinase Kinase Kinase 5 - pharmacology Mice Microglia - metabolism Neurochemistry Neurology Neurosciences Original Paper Pharmacokinetics Pharmacology Substrates Tumor necrosis factor-α
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