AS1411 aptamer improves therapeutic efficacy of PEGylated nanoliposomes loaded with gefitinib in the mice bearing CT26 colon carcinoma

In this work, a tumor-targeting liposome containing anti-nucleolin aptamer AS1411 (Apt-Lip-GEF) was developed to deliver gefitinib (GEF) for the treatment of colon cancer. The prepared liposomes were characterized using their morphological properties, size dispersity, zeta potential, encapsulation e...

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Veröffentlicht in:	Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2022-12, Vol.24 (12), p.252, Article 252
Hauptverfasser:	Tanzadehpanah, Hamid, Mahaki, Hanie, Manoochehri, Hamed, Soleimani, Meysam, Najafi, Rezvan
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animal models Anticancer properties Apoptosis Aptamers Biocompatibility Cancer Characterization and Evaluation of Materials Chemistry and Materials Science Colon Colon cancer Colorectal cancer Colorectal carcinoma Cytotoxicity Electrophoresis Encapsulation Flow cytometry Fluorescence microscopy Gefitinib Gel electrophoresis Inhibitor drugs Inorganic Chemistry Lasers Liposomes Materials Science Nanoparticles Nanotechnology Necrosis Nucleolin Optical Devices Optics Photonics Physical Chemistry Research Paper Targeted cancer therapy Toxicity Tumors Zeta potential
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