Upconversion NaYF4:Yb/Er–TiO2–Ti3C2 Heterostructure-Based Near-Infrared Light-Driven Photoelectrochemical Biosensor for Highly Sensitive and Selective d‑Serine Detection
A near-infrared (NIR) light-driven NaYF4:Yb/Er–TiO2–Ti3C2 (NYF–TiO2–Ti3C2) heterostructure-based photoelectrochemical (PEC) biosensing platform was constructed for highly sensitive d-serine (d-ser) detection. Accurate d-ser detection depends on the model biocatalyst, d-amino acid oxidase (DAAO), whi...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2022-11, Vol.94 (46), p.16246-16253 |
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| creator | Huang, Likun Liang, Zhishan Zhang, Fang Luo, Hui Liang, Ruilian Han, Fangjie Wu, Zhifang Han, Dongxue Shen, Jun Niu, Li |
| description | A near-infrared (NIR) light-driven NaYF4:Yb/Er–TiO2–Ti3C2 (NYF–TiO2–Ti3C2) heterostructure-based photoelectrochemical (PEC) biosensing platform was constructed for highly sensitive d-serine (d-ser) detection. Accurate d-ser detection depends on the model biocatalyst, d-amino acid oxidase (DAAO), which converts d-ser into hydroxypyruvate and an equimolar concentration of hydrogen peroxide (H2O2) via an enzymatic reaction. The TiO2–Ti3C2 semiconductor and NaYF4:Yb/Er optical transducer formed a Schottky junction that provided an irreversible channel for electron transfer. Infrared light was converted into absorbable multiemission light, thereby effectively increasing light absorption. Simultaneously, the generated H2O2 rapidly scavenged photogenerated holes to separate electron–hole pairs, which amplified the photocurrent signal. Under optimal conditions, the NIR light-driven PEC biosensor exhibited an excellent PEC performance for d-ser detection, with a wide linear range of 2–1650 μmol L–1 and detection limit as low as 0.286 μmol L–1. Importantly, high detection reproducibility and accuracy were achieved using this strategy for analyzing human serum and rat cerebrospinal fluid (CSF) specimens. The admirable applicability of the NYF–TiO2–Ti3C2-based PEC biosensor for detecting d-ser may lead to further opportunities for detecting other disease-related biomarkers. |
| doi_str_mv | 10.1021/acs.analchem.2c04101 |
| format | Article |
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Accurate d-ser detection depends on the model biocatalyst, d-amino acid oxidase (DAAO), which converts d-ser into hydroxypyruvate and an equimolar concentration of hydrogen peroxide (H2O2) via an enzymatic reaction. The TiO2–Ti3C2 semiconductor and NaYF4:Yb/Er optical transducer formed a Schottky junction that provided an irreversible channel for electron transfer. Infrared light was converted into absorbable multiemission light, thereby effectively increasing light absorption. Simultaneously, the generated H2O2 rapidly scavenged photogenerated holes to separate electron–hole pairs, which amplified the photocurrent signal. Under optimal conditions, the NIR light-driven PEC biosensor exhibited an excellent PEC performance for d-ser detection, with a wide linear range of 2–1650 μmol L–1 and detection limit as low as 0.286 μmol L–1. Importantly, high detection reproducibility and accuracy were achieved using this strategy for analyzing human serum and rat cerebrospinal fluid (CSF) specimens. The admirable applicability of the NYF–TiO2–Ti3C2-based PEC biosensor for detecting d-ser may lead to further opportunities for detecting other disease-related biomarkers.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/acs.analchem.2c04101</identifier><language>eng</language><publisher>Washington: American Chemical Society</publisher><subject>Amino acid oxidase ; Amino acids ; Biomarkers ; Biosensors ; Cerebrospinal fluid ; Chemistry ; D-Amino-acid oxidase ; D-Serine ; Electromagnetic absorption ; Electron transfer ; Erbium ; Fluorides ; Heterostructures ; Hydrogen peroxide ; I.R. radiation ; Light ; Near infrared radiation ; Photoelectric effect ; Sodium compounds ; Titanium dioxide ; Ytterbium</subject><ispartof>Analytical chemistry (Washington), 2022-11, Vol.94 (46), p.16246-16253</ispartof><rights>2022 American Chemical Society</rights><rights>Copyright American Chemical Society Nov 22, 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-3652-2903 ; 0000-0001-7746-5285 ; 0000-0002-7343-2221</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.analchem.2c04101$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.analchem.2c04101$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,27076,27924,27925,56738,56788</link.rule.ids></links><search><creatorcontrib>Huang, Likun</creatorcontrib><creatorcontrib>Liang, Zhishan</creatorcontrib><creatorcontrib>Zhang, Fang</creatorcontrib><creatorcontrib>Luo, Hui</creatorcontrib><creatorcontrib>Liang, Ruilian</creatorcontrib><creatorcontrib>Han, Fangjie</creatorcontrib><creatorcontrib>Wu, Zhifang</creatorcontrib><creatorcontrib>Han, Dongxue</creatorcontrib><creatorcontrib>Shen, Jun</creatorcontrib><creatorcontrib>Niu, Li</creatorcontrib><title>Upconversion NaYF4:Yb/Er–TiO2–Ti3C2 Heterostructure-Based Near-Infrared Light-Driven Photoelectrochemical Biosensor for Highly Sensitive and Selective d‑Serine Detection</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. Chem</addtitle><description>A near-infrared (NIR) light-driven NaYF4:Yb/Er–TiO2–Ti3C2 (NYF–TiO2–Ti3C2) heterostructure-based photoelectrochemical (PEC) biosensing platform was constructed for highly sensitive d-serine (d-ser) detection. Accurate d-ser detection depends on the model biocatalyst, d-amino acid oxidase (DAAO), which converts d-ser into hydroxypyruvate and an equimolar concentration of hydrogen peroxide (H2O2) via an enzymatic reaction. The TiO2–Ti3C2 semiconductor and NaYF4:Yb/Er optical transducer formed a Schottky junction that provided an irreversible channel for electron transfer. Infrared light was converted into absorbable multiemission light, thereby effectively increasing light absorption. Simultaneously, the generated H2O2 rapidly scavenged photogenerated holes to separate electron–hole pairs, which amplified the photocurrent signal. Under optimal conditions, the NIR light-driven PEC biosensor exhibited an excellent PEC performance for d-ser detection, with a wide linear range of 2–1650 μmol L–1 and detection limit as low as 0.286 μmol L–1. Importantly, high detection reproducibility and accuracy were achieved using this strategy for analyzing human serum and rat cerebrospinal fluid (CSF) specimens. The admirable applicability of the NYF–TiO2–Ti3C2-based PEC biosensor for detecting d-ser may lead to further opportunities for detecting other disease-related biomarkers.</description><subject>Amino acid oxidase</subject><subject>Amino acids</subject><subject>Biomarkers</subject><subject>Biosensors</subject><subject>Cerebrospinal fluid</subject><subject>Chemistry</subject><subject>D-Amino-acid oxidase</subject><subject>D-Serine</subject><subject>Electromagnetic absorption</subject><subject>Electron transfer</subject><subject>Erbium</subject><subject>Fluorides</subject><subject>Heterostructures</subject><subject>Hydrogen peroxide</subject><subject>I.R. radiation</subject><subject>Light</subject><subject>Near infrared radiation</subject><subject>Photoelectric effect</subject><subject>Sodium compounds</subject><subject>Titanium dioxide</subject><subject>Ytterbium</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpFkU1OwzAQhS0EEuXnBiwssU4Z24mTsoNSKFIFSC0LVpHjTGiqYIPtIrHjCoiDcCdOgsOPWIxG7-mbsTWPkAMGQwacHSnth8qoTi_xYcg1pAzYBhmwjEMii4JvkgEAiITnANtkx_sVAIuMHJCP20dtzTM631pDr9TdeXp8Vx1N3Ofr-6K95t9NjDmdYkBnfXBrHdYOk1PlsaZXqFxyaRqnXFSz9n4ZkjPXPqOhN0sbLHaog7P9x1qtOnraWo_GW0ebWNPIdy90Hp02xCGqTB1VP9Or-vP1bY6uNUjP4uvRtGaPbDWq87j_23fJ7flkMZ4ms-uLy_HJLFGsyENS5EWuRF1BjZkUWgtdswa5lBnKoqryUaZqKRuFaSbTSqKAJh6nqdUoLZSAVOySw5-9j84-rdGHcmXXLt7YlzxPRcY5ZD0FP1RM4B9gUPaxlL35F0v5G4v4AlqKibE</recordid><startdate>20221122</startdate><enddate>20221122</enddate><creator>Huang, Likun</creator><creator>Liang, Zhishan</creator><creator>Zhang, Fang</creator><creator>Luo, Hui</creator><creator>Liang, Ruilian</creator><creator>Han, Fangjie</creator><creator>Wu, Zhifang</creator><creator>Han, Dongxue</creator><creator>Shen, Jun</creator><creator>Niu, Li</creator><general>American Chemical Society</general><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0003-3652-2903</orcidid><orcidid>https://orcid.org/0000-0001-7746-5285</orcidid><orcidid>https://orcid.org/0000-0002-7343-2221</orcidid></search><sort><creationdate>20221122</creationdate><title>Upconversion NaYF4:Yb/Er–TiO2–Ti3C2 Heterostructure-Based Near-Infrared Light-Driven Photoelectrochemical Biosensor for Highly Sensitive and Selective d‑Serine Detection</title><author>Huang, Likun ; 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Chem</addtitle><date>2022-11-22</date><risdate>2022</risdate><volume>94</volume><issue>46</issue><spage>16246</spage><epage>16253</epage><pages>16246-16253</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><abstract>A near-infrared (NIR) light-driven NaYF4:Yb/Er–TiO2–Ti3C2 (NYF–TiO2–Ti3C2) heterostructure-based photoelectrochemical (PEC) biosensing platform was constructed for highly sensitive d-serine (d-ser) detection. Accurate d-ser detection depends on the model biocatalyst, d-amino acid oxidase (DAAO), which converts d-ser into hydroxypyruvate and an equimolar concentration of hydrogen peroxide (H2O2) via an enzymatic reaction. The TiO2–Ti3C2 semiconductor and NaYF4:Yb/Er optical transducer formed a Schottky junction that provided an irreversible channel for electron transfer. Infrared light was converted into absorbable multiemission light, thereby effectively increasing light absorption. Simultaneously, the generated H2O2 rapidly scavenged photogenerated holes to separate electron–hole pairs, which amplified the photocurrent signal. Under optimal conditions, the NIR light-driven PEC biosensor exhibited an excellent PEC performance for d-ser detection, with a wide linear range of 2–1650 μmol L–1 and detection limit as low as 0.286 μmol L–1. Importantly, high detection reproducibility and accuracy were achieved using this strategy for analyzing human serum and rat cerebrospinal fluid (CSF) specimens. The admirable applicability of the NYF–TiO2–Ti3C2-based PEC biosensor for detecting d-ser may lead to further opportunities for detecting other disease-related biomarkers.</abstract><cop>Washington</cop><pub>American Chemical Society</pub><doi>10.1021/acs.analchem.2c04101</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3652-2903</orcidid><orcidid>https://orcid.org/0000-0001-7746-5285</orcidid><orcidid>https://orcid.org/0000-0002-7343-2221</orcidid></addata></record> |
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| subjects | Amino acid oxidase Amino acids Biomarkers Biosensors Cerebrospinal fluid Chemistry D-Amino-acid oxidase D-Serine Electromagnetic absorption Electron transfer Erbium Fluorides Heterostructures Hydrogen peroxide I.R. radiation Light Near infrared radiation Photoelectric effect Sodium compounds Titanium dioxide Ytterbium |
| title | Upconversion NaYF4:Yb/Er–TiO2–Ti3C2 Heterostructure-Based Near-Infrared Light-Driven Photoelectrochemical Biosensor for Highly Sensitive and Selective d‑Serine Detection |
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