Mesoporous Silica Nano-Particles Based Arctigenin (MSN-ARC-G) Attenuates Intervertebral Disc Degeneration (IVDD) and Inflammation in Mice and Human NP Cells by Suppressing the MAPK/ERK Pathway

Intervertebral disc degeneration (IVDD) is a multifactorial disease that mainly takes place in the nucleus pulposus (NP) and the fibrocartilaginous annulus fibrosus, and causes lower back pain. Fructus arctii, which is a traditional Chinese herb, shows a potential curative effect in relieving inflam...

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Veröffentlicht in:	JOM (1989) 2022-12, Vol.74 (12), p.4612-4620
Hauptverfasser:	Wang, Shanzheng, Jia, Jun, Chen, Changhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Back pain Chemistry/Food Science Chinese medicine Composite structures Cytokines Degeneration Degenerative disc disease Drug delivery systems Earth Sciences Electron microscopes Engineering Environment Health services Immunofluorescence Inflammation Interactions between Biomaterials and Biological Tissues and Cells Intervertebral discs Kinases Microscopes Morphology Nanoparticles Physics Silicon dioxide Staining
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