Correlation between plasma glutathione peroxidase 4 and N-acetylneuraminic acid levels with clinical risk stratification and prognosis of patients with acute coronary syndrome
To investigate the correlation between plasma glutathione peroxidase 4 (GPX4) and N-acetyl-neuraminic acid (Neu5Ac) with clinical risk stratification and outcomes of acute coronary syndrome (ACS) patients. Between October 2018 and July 2019, 413 patients that were scheduled for coronary angiography...
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| Veröffentlicht in: | Saudi medical journal 2022-10, Vol.43 (10), p.1103-1110 |
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| creator | Li, Miao-Nan Bao, Bing-Wei Si-Yu, Ding Chun-Fei, Ji Xiao-Jun, Shi Da-Sheng, Gao Qin, Gao Hong-Ju, Wang |
| description | To investigate the correlation between plasma glutathione peroxidase 4 (GPX4) and N-acetyl-neuraminic acid (Neu5Ac) with clinical risk stratification and outcomes of acute coronary syndrome (ACS) patients.
Between October 2018 and July 2019, 413 patients that were scheduled for coronary angiography were enrolled in this prospective study at the First Affiliated Hospital of Bengbu Medical College, Bengbu, China. Patients were divided into control and ACS groups. Patients with ACS were divided into 3 risk levels based on their thrombolysis in myocardial infarction risk score. After discharge, ACS patients were followed for the incidence of major adverse cardiac events (MACEs). For the analysis of cumulative endpoint event occurrences, the Kaplan-Meier method was applied.
The ACS group had lower plasma GPX4 but higher Neu5Ac levels than the control group. There was a greater increase in plasma Neu5Ac in the high-risk group when compared with the medium-risk and low-risk groups, while GPX4 levels were higher in the low-risk group. The MACEs group had higher plasma Neu5Ac but lower GPX4 levels than the non-MACEs group. The plasma Neu5Ac was an independent risk factor but GPX4 was a protective factor for MACEs.
Glutathione peroxidase 4 and Neu5Ac levels in plasma can be used to diagnose, stratify risks, and predict long-term outcomes in patients with ACS. |
| doi_str_mv | 10.15537/smj.2022.43.10.20220444 |
| format | Article |
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Between October 2018 and July 2019, 413 patients that were scheduled for coronary angiography were enrolled in this prospective study at the First Affiliated Hospital of Bengbu Medical College, Bengbu, China. Patients were divided into control and ACS groups. Patients with ACS were divided into 3 risk levels based on their thrombolysis in myocardial infarction risk score. After discharge, ACS patients were followed for the incidence of major adverse cardiac events (MACEs). For the analysis of cumulative endpoint event occurrences, the Kaplan-Meier method was applied.
The ACS group had lower plasma GPX4 but higher Neu5Ac levels than the control group. There was a greater increase in plasma Neu5Ac in the high-risk group when compared with the medium-risk and low-risk groups, while GPX4 levels were higher in the low-risk group. The MACEs group had higher plasma Neu5Ac but lower GPX4 levels than the non-MACEs group. The plasma Neu5Ac was an independent risk factor but GPX4 was a protective factor for MACEs.
Glutathione peroxidase 4 and Neu5Ac levels in plasma can be used to diagnose, stratify risks, and predict long-term outcomes in patients with ACS.</description><identifier>ISSN: 0379-5284</identifier><identifier>EISSN: 1658-3175</identifier><identifier>DOI: 10.15537/smj.2022.43.10.20220444</identifier><identifier>PMID: 36261209</identifier><language>eng</language><publisher>Saudi Arabia: Saudi Medical Journal</publisher><subject>Acids ; Acute coronary syndrome ; Acute Coronary Syndrome - diagnosis ; Acute coronary syndromes ; Biochemistry ; Development and progression ; Diagnosis ; Health aspects ; Humans ; Medical imaging ; Medical prognosis ; N-Acetylneuraminic Acid ; Peroxidase ; Phospholipid Hydroperoxide Glutathione Peroxidase ; Physiological aspects ; Plasma ; Prognosis ; Prospective Studies ; Risk Assessment ; Risk Factors ; Sialic acids</subject><ispartof>Saudi medical journal, 2022-10, Vol.43 (10), p.1103-1110</ispartof><rights>Copyright: © Saudi Medical Journal.</rights><rights>COPYRIGHT 2022 Saudi Medical Journal</rights><rights>Saudi Medical Journal 2022. This work is licensed under the Creative Commons Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-601ac07a3d3dc7eaa15c941e8d36d79833a4e0ac068c72277a651c473113b6c53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36261209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Miao-Nan</creatorcontrib><creatorcontrib>Bao, Bing-Wei</creatorcontrib><creatorcontrib>Si-Yu, Ding</creatorcontrib><creatorcontrib>Chun-Fei, Ji</creatorcontrib><creatorcontrib>Xiao-Jun, Shi</creatorcontrib><creatorcontrib>Da-Sheng, Gao</creatorcontrib><creatorcontrib>Qin, Gao</creatorcontrib><creatorcontrib>Hong-Ju, Wang</creatorcontrib><title>Correlation between plasma glutathione peroxidase 4 and N-acetylneuraminic acid levels with clinical risk stratification and prognosis of patients with acute coronary syndrome</title><title>Saudi medical journal</title><addtitle>Saudi Med J</addtitle><description>To investigate the correlation between plasma glutathione peroxidase 4 (GPX4) and N-acetyl-neuraminic acid (Neu5Ac) with clinical risk stratification and outcomes of acute coronary syndrome (ACS) patients.
Between October 2018 and July 2019, 413 patients that were scheduled for coronary angiography were enrolled in this prospective study at the First Affiliated Hospital of Bengbu Medical College, Bengbu, China. Patients were divided into control and ACS groups. Patients with ACS were divided into 3 risk levels based on their thrombolysis in myocardial infarction risk score. After discharge, ACS patients were followed for the incidence of major adverse cardiac events (MACEs). For the analysis of cumulative endpoint event occurrences, the Kaplan-Meier method was applied.
The ACS group had lower plasma GPX4 but higher Neu5Ac levels than the control group. There was a greater increase in plasma Neu5Ac in the high-risk group when compared with the medium-risk and low-risk groups, while GPX4 levels were higher in the low-risk group. The MACEs group had higher plasma Neu5Ac but lower GPX4 levels than the non-MACEs group. The plasma Neu5Ac was an independent risk factor but GPX4 was a protective factor for MACEs.
Glutathione peroxidase 4 and Neu5Ac levels in plasma can be used to diagnose, stratify risks, and predict long-term outcomes in patients with ACS.</description><subject>Acids</subject><subject>Acute coronary syndrome</subject><subject>Acute Coronary Syndrome - diagnosis</subject><subject>Acute coronary syndromes</subject><subject>Biochemistry</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Medical imaging</subject><subject>Medical prognosis</subject><subject>N-Acetylneuraminic Acid</subject><subject>Peroxidase</subject><subject>Phospholipid Hydroperoxide Glutathione Peroxidase</subject><subject>Physiological aspects</subject><subject>Plasma</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Sialic acids</subject><issn>0379-5284</issn><issn>1658-3175</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptUstu1DAUjRCIDoVfQJZYJ_gVO1lWI15SBRtYWx77ZurBsQfboZ2v4hdx2ikICXlh6_ice-6raRDBHel7Jt_m-dBRTGnHWVfB9Yk550-aDRH90DIi-6fNBjM5tj0d-EXzIucDxkwILJ43F0xQQSgeN82vbUwJvC4uBrSDcgsQ0NHrPGu090vR5ab-ADpCinfO6gyIIx0s-txqA-XkAyxJzy44g7RxFnn4CT6jW1dukPErrj1KLn9HuaRqM1Xg3mwNckxxH2J2GcUJHSsOoZy12iwFkIkpBp1OKJ-CTXGGl82zSfsMr873ZfPt_buv24_t9ZcPn7ZX163hApdWYKINlppZZo0ErUlvRk5gsExYOQ6MaQ64UsRgJKVSatETwyUjhO2E6dll8-Yhbk3xxwK5qENcUqiWikqO-TCMI_3L2msPyoUp1hrN7LJRV5JyKXtBxsrq_sOqx8LsTO3u5Cr-j2B4EJgUc04wqWNyc22DIljdL4CqC6DWqSvOVvBxAar09TnvZTeD_SN8nDj7DS4Mr-I</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Li, Miao-Nan</creator><creator>Bao, Bing-Wei</creator><creator>Si-Yu, Ding</creator><creator>Chun-Fei, Ji</creator><creator>Xiao-Jun, Shi</creator><creator>Da-Sheng, Gao</creator><creator>Qin, Gao</creator><creator>Hong-Ju, Wang</creator><general>Saudi Medical Journal</general><general>Prince Sultan Military Medical City (PSMMC)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20221001</creationdate><title>Correlation between plasma glutathione peroxidase 4 and N-acetylneuraminic acid levels with clinical risk stratification and prognosis of patients with acute coronary syndrome</title><author>Li, Miao-Nan ; Bao, Bing-Wei ; Si-Yu, Ding ; Chun-Fei, Ji ; Xiao-Jun, Shi ; Da-Sheng, Gao ; Qin, Gao ; Hong-Ju, Wang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-601ac07a3d3dc7eaa15c941e8d36d79833a4e0ac068c72277a651c473113b6c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acids</topic><topic>Acute coronary syndrome</topic><topic>Acute Coronary Syndrome - diagnosis</topic><topic>Acute coronary syndromes</topic><topic>Biochemistry</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Medical imaging</topic><topic>Medical prognosis</topic><topic>N-Acetylneuraminic Acid</topic><topic>Peroxidase</topic><topic>Phospholipid Hydroperoxide Glutathione Peroxidase</topic><topic>Physiological aspects</topic><topic>Plasma</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Sialic acids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Miao-Nan</creatorcontrib><creatorcontrib>Bao, Bing-Wei</creatorcontrib><creatorcontrib>Si-Yu, Ding</creatorcontrib><creatorcontrib>Chun-Fei, Ji</creatorcontrib><creatorcontrib>Xiao-Jun, Shi</creatorcontrib><creatorcontrib>Da-Sheng, Gao</creatorcontrib><creatorcontrib>Qin, Gao</creatorcontrib><creatorcontrib>Hong-Ju, Wang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Saudi medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Miao-Nan</au><au>Bao, Bing-Wei</au><au>Si-Yu, Ding</au><au>Chun-Fei, Ji</au><au>Xiao-Jun, Shi</au><au>Da-Sheng, Gao</au><au>Qin, Gao</au><au>Hong-Ju, Wang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between plasma glutathione peroxidase 4 and N-acetylneuraminic acid levels with clinical risk stratification and prognosis of patients with acute coronary syndrome</atitle><jtitle>Saudi medical journal</jtitle><addtitle>Saudi Med J</addtitle><date>2022-10-01</date><risdate>2022</risdate><volume>43</volume><issue>10</issue><spage>1103</spage><epage>1110</epage><pages>1103-1110</pages><issn>0379-5284</issn><eissn>1658-3175</eissn><abstract>To investigate the correlation between plasma glutathione peroxidase 4 (GPX4) and N-acetyl-neuraminic acid (Neu5Ac) with clinical risk stratification and outcomes of acute coronary syndrome (ACS) patients.
Between October 2018 and July 2019, 413 patients that were scheduled for coronary angiography were enrolled in this prospective study at the First Affiliated Hospital of Bengbu Medical College, Bengbu, China. Patients were divided into control and ACS groups. Patients with ACS were divided into 3 risk levels based on their thrombolysis in myocardial infarction risk score. After discharge, ACS patients were followed for the incidence of major adverse cardiac events (MACEs). For the analysis of cumulative endpoint event occurrences, the Kaplan-Meier method was applied.
The ACS group had lower plasma GPX4 but higher Neu5Ac levels than the control group. There was a greater increase in plasma Neu5Ac in the high-risk group when compared with the medium-risk and low-risk groups, while GPX4 levels were higher in the low-risk group. The MACEs group had higher plasma Neu5Ac but lower GPX4 levels than the non-MACEs group. The plasma Neu5Ac was an independent risk factor but GPX4 was a protective factor for MACEs.
Glutathione peroxidase 4 and Neu5Ac levels in plasma can be used to diagnose, stratify risks, and predict long-term outcomes in patients with ACS.</abstract><cop>Saudi Arabia</cop><pub>Saudi Medical Journal</pub><pmid>36261209</pmid><doi>10.15537/smj.2022.43.10.20220444</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Saudi medical journal, 2022-10, Vol.43 (10), p.1103-1110 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Acids Acute coronary syndrome Acute Coronary Syndrome - diagnosis Acute coronary syndromes Biochemistry Development and progression Diagnosis Health aspects Humans Medical imaging Medical prognosis N-Acetylneuraminic Acid Peroxidase Phospholipid Hydroperoxide Glutathione Peroxidase Physiological aspects Plasma Prognosis Prospective Studies Risk Assessment Risk Factors Sialic acids |
| title | Correlation between plasma glutathione peroxidase 4 and N-acetylneuraminic acid levels with clinical risk stratification and prognosis of patients with acute coronary syndrome |
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