25 years of the segmentation clock gene
Delta is part of the Notch signalling pathway, which signals between cells to activate the transcription of genes - including those of the Hes and her families - in neighbouring cells. [...]Delta and Lunaticfringe control the timing of HES7 and heri and her7 oscillations in neighbouring cells, which...
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| Veröffentlicht in: | Nature (London) 2022-11, Vol.611 (7937), p.1-2 |
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| creator | Kageyama, Ryoichiro |
| description | Delta is part of the Notch signalling pathway, which signals between cells to activate the transcription of genes - including those of the Hes and her families - in neighbouring cells. [...]Delta and Lunaticfringe control the timing of HES7 and heri and her7 oscillations in neighbouring cells, which leads to synchronization7,9. Mathematical theorists have created models that have provided surprising insights - for example, demonstrating that the oscillations in gene expression are robust even when 90% of protein synthesis is blocked18. Oscillatory gene expression occurs in many cell types - for example, it has a role in regulating the proliferation of neural stem cells and muscle progenitor cells19. |
| doi_str_mv | 10.1038/d41586-022-03561-3 |
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| identifier | ISSN: 0028-0836 |
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| source | Nature; SpringerLink Journals - AutoHoldings |
| subjects | Cell proliferation Clock gene Embryos Gene expression Mathematical models Muscles Neural stem cells Oscillations Protein biosynthesis Protein synthesis Proteins Robustness (mathematics) Segmentation Signal transduction Stem cells Vertebrates |
| title | 25 years of the segmentation clock gene |
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