Review of factors affecting citrus polyphenol bioavailability and their importance in designing in vitro, animal, and intervention studies
Evidence from in vitro, animal, and human studies links citrus fruit consumption with several health‐promoting effects. However, many in vitro studies disregard bioavailability data, a key factor determining responses in humans. Citrus (poly)phenol metabolism and bioavailability follow specific path...
Gespeichert in:
| Veröffentlicht in: | Comprehensive reviews in food science and food safety 2022-11, Vol.21 (6), p.4509-4545 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4545 |
|---|---|
| container_issue | 6 |
| container_start_page | 4509 |
| container_title | Comprehensive reviews in food science and food safety |
| container_volume | 21 |
| creator | Visvanathan, Rizliya Williamson, Gary |
| description | Evidence from in vitro, animal, and human studies links citrus fruit consumption with several health‐promoting effects. However, many in vitro studies disregard bioavailability data, a key factor determining responses in humans. Citrus (poly)phenol metabolism and bioavailability follow specific pathways that vary widely among individuals and are affected by several intrinsic (age, sex, gut microbiota, metabolic state, genetic polymorphisms) and extrinsic (food matrix, co‐consumed food, (poly)phenol solubility, dose, food processing, lifestyle) factors. The gut microbiota is crucial to both absorption of citrus (poly)phenols and the production of catabolites, and absorption of both takes place mostly in the colon. Citrus (poly)phenol absorption can reach up to 100% in some individuals when the sum of the gut microbiota products are taken into account. This review emphasizes the importance of understanding citrus (poly)phenol absorption, metabolism, and bioavailability using evidence primarily derived from human studies in designing in vitro, animal, and further human clinical studies. |
| doi_str_mv | 10.1111/1541-4337.13057 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2738971825</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2738971825</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4137-31a182b9b6529f9f12d25d98136259669f5f47ff70dafd8c5d0a0d7474f829833</originalsourceid><addsrcrecordid>eNqFkE9PwyAYh4nROJ2evRkSr-tWSint0SxOTUxMFj0TWmDDdFCBbtlX8FPL_mi8yeWFN8_7vOQHwA1KxyieCSI5SnKM6RjhlNATcPHbOf1zH4BL7z_SNKeEludggAtUYlTgC_A1l2stN9AqqHgTrPOQKyWboM0CNjq43sPOtttuKY1tYa0tX3Pd8lq3OmwhNwKGpdQO6lVnXeCmkVAbKKTXC7NzxMc6auwosnrF29F-Rpsg3VqaoK2BPvRCS38FzhRvvbw-1iF4nz28TZ-Sl9fH5-n9S9LkCNMEI47KrK7qgmSVqhTKREZEVSJcZKQqikoRlVOlaCq4EmVDRMpTQXOaqzKrSoyH4O7g7Zz97KUP7MP2zsSVLKO4rGjUk0hNDlTjrPdOKta5-H-3ZShlu-zZLl22S5fts48Tt0dvX6-k-OV_wo5AcQA2upXb_3xsOp_hg_kbV2-QEA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2738971825</pqid></control><display><type>article</type><title>Review of factors affecting citrus polyphenol bioavailability and their importance in designing in vitro, animal, and intervention studies</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Visvanathan, Rizliya ; Williamson, Gary</creator><creatorcontrib>Visvanathan, Rizliya ; Williamson, Gary</creatorcontrib><description>Evidence from in vitro, animal, and human studies links citrus fruit consumption with several health‐promoting effects. However, many in vitro studies disregard bioavailability data, a key factor determining responses in humans. Citrus (poly)phenol metabolism and bioavailability follow specific pathways that vary widely among individuals and are affected by several intrinsic (age, sex, gut microbiota, metabolic state, genetic polymorphisms) and extrinsic (food matrix, co‐consumed food, (poly)phenol solubility, dose, food processing, lifestyle) factors. The gut microbiota is crucial to both absorption of citrus (poly)phenols and the production of catabolites, and absorption of both takes place mostly in the colon. Citrus (poly)phenol absorption can reach up to 100% in some individuals when the sum of the gut microbiota products are taken into account. This review emphasizes the importance of understanding citrus (poly)phenol absorption, metabolism, and bioavailability using evidence primarily derived from human studies in designing in vitro, animal, and further human clinical studies.</description><identifier>ISSN: 1541-4337</identifier><identifier>EISSN: 1541-4337</identifier><identifier>DOI: 10.1111/1541-4337.13057</identifier><identifier>PMID: 36183163</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>(poly)phenol metabolism ; Animals ; Bioavailability ; Biological Availability ; Catabolites ; Citrus ; citrus fruits ; Food processing ; Gene polymorphism ; gut microbiome ; Humans ; interindividual variation ; Intestinal microflora ; Microbiota ; Phenol ; Phenols ; Polyphenols</subject><ispartof>Comprehensive reviews in food science and food safety, 2022-11, Vol.21 (6), p.4509-4545</ispartof><rights>2022 The Authors. published by Wiley Periodicals LLC on behalf of Institute of Food Technologists.</rights><rights>2022 The Authors. Comprehensive Reviews in Food Science and Food Safety published by Wiley Periodicals LLC on behalf of Institute of Food Technologists.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4137-31a182b9b6529f9f12d25d98136259669f5f47ff70dafd8c5d0a0d7474f829833</citedby><cites>FETCH-LOGICAL-c4137-31a182b9b6529f9f12d25d98136259669f5f47ff70dafd8c5d0a0d7474f829833</cites><orcidid>0000-0002-5624-6267</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1541-4337.13057$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1541-4337.13057$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36183163$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Visvanathan, Rizliya</creatorcontrib><creatorcontrib>Williamson, Gary</creatorcontrib><title>Review of factors affecting citrus polyphenol bioavailability and their importance in designing in vitro, animal, and intervention studies</title><title>Comprehensive reviews in food science and food safety</title><addtitle>Compr Rev Food Sci Food Saf</addtitle><description>Evidence from in vitro, animal, and human studies links citrus fruit consumption with several health‐promoting effects. However, many in vitro studies disregard bioavailability data, a key factor determining responses in humans. Citrus (poly)phenol metabolism and bioavailability follow specific pathways that vary widely among individuals and are affected by several intrinsic (age, sex, gut microbiota, metabolic state, genetic polymorphisms) and extrinsic (food matrix, co‐consumed food, (poly)phenol solubility, dose, food processing, lifestyle) factors. The gut microbiota is crucial to both absorption of citrus (poly)phenols and the production of catabolites, and absorption of both takes place mostly in the colon. Citrus (poly)phenol absorption can reach up to 100% in some individuals when the sum of the gut microbiota products are taken into account. This review emphasizes the importance of understanding citrus (poly)phenol absorption, metabolism, and bioavailability using evidence primarily derived from human studies in designing in vitro, animal, and further human clinical studies.</description><subject>(poly)phenol metabolism</subject><subject>Animals</subject><subject>Bioavailability</subject><subject>Biological Availability</subject><subject>Catabolites</subject><subject>Citrus</subject><subject>citrus fruits</subject><subject>Food processing</subject><subject>Gene polymorphism</subject><subject>gut microbiome</subject><subject>Humans</subject><subject>interindividual variation</subject><subject>Intestinal microflora</subject><subject>Microbiota</subject><subject>Phenol</subject><subject>Phenols</subject><subject>Polyphenols</subject><issn>1541-4337</issn><issn>1541-4337</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNqFkE9PwyAYh4nROJ2evRkSr-tWSint0SxOTUxMFj0TWmDDdFCBbtlX8FPL_mi8yeWFN8_7vOQHwA1KxyieCSI5SnKM6RjhlNATcPHbOf1zH4BL7z_SNKeEludggAtUYlTgC_A1l2stN9AqqHgTrPOQKyWboM0CNjq43sPOtttuKY1tYa0tX3Pd8lq3OmwhNwKGpdQO6lVnXeCmkVAbKKTXC7NzxMc6auwosnrF29F-Rpsg3VqaoK2BPvRCS38FzhRvvbw-1iF4nz28TZ-Sl9fH5-n9S9LkCNMEI47KrK7qgmSVqhTKREZEVSJcZKQqikoRlVOlaCq4EmVDRMpTQXOaqzKrSoyH4O7g7Zz97KUP7MP2zsSVLKO4rGjUk0hNDlTjrPdOKta5-H-3ZShlu-zZLl22S5fts48Tt0dvX6-k-OV_wo5AcQA2upXb_3xsOp_hg_kbV2-QEA</recordid><startdate>202211</startdate><enddate>202211</enddate><creator>Visvanathan, Rizliya</creator><creator>Williamson, Gary</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-5624-6267</orcidid></search><sort><creationdate>202211</creationdate><title>Review of factors affecting citrus polyphenol bioavailability and their importance in designing in vitro, animal, and intervention studies</title><author>Visvanathan, Rizliya ; Williamson, Gary</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4137-31a182b9b6529f9f12d25d98136259669f5f47ff70dafd8c5d0a0d7474f829833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>(poly)phenol metabolism</topic><topic>Animals</topic><topic>Bioavailability</topic><topic>Biological Availability</topic><topic>Catabolites</topic><topic>Citrus</topic><topic>citrus fruits</topic><topic>Food processing</topic><topic>Gene polymorphism</topic><topic>gut microbiome</topic><topic>Humans</topic><topic>interindividual variation</topic><topic>Intestinal microflora</topic><topic>Microbiota</topic><topic>Phenol</topic><topic>Phenols</topic><topic>Polyphenols</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Visvanathan, Rizliya</creatorcontrib><creatorcontrib>Williamson, Gary</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Comprehensive reviews in food science and food safety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Visvanathan, Rizliya</au><au>Williamson, Gary</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Review of factors affecting citrus polyphenol bioavailability and their importance in designing in vitro, animal, and intervention studies</atitle><jtitle>Comprehensive reviews in food science and food safety</jtitle><addtitle>Compr Rev Food Sci Food Saf</addtitle><date>2022-11</date><risdate>2022</risdate><volume>21</volume><issue>6</issue><spage>4509</spage><epage>4545</epage><pages>4509-4545</pages><issn>1541-4337</issn><eissn>1541-4337</eissn><abstract>Evidence from in vitro, animal, and human studies links citrus fruit consumption with several health‐promoting effects. However, many in vitro studies disregard bioavailability data, a key factor determining responses in humans. Citrus (poly)phenol metabolism and bioavailability follow specific pathways that vary widely among individuals and are affected by several intrinsic (age, sex, gut microbiota, metabolic state, genetic polymorphisms) and extrinsic (food matrix, co‐consumed food, (poly)phenol solubility, dose, food processing, lifestyle) factors. The gut microbiota is crucial to both absorption of citrus (poly)phenols and the production of catabolites, and absorption of both takes place mostly in the colon. Citrus (poly)phenol absorption can reach up to 100% in some individuals when the sum of the gut microbiota products are taken into account. This review emphasizes the importance of understanding citrus (poly)phenol absorption, metabolism, and bioavailability using evidence primarily derived from human studies in designing in vitro, animal, and further human clinical studies.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36183163</pmid><doi>10.1111/1541-4337.13057</doi><tpages>37</tpages><orcidid>https://orcid.org/0000-0002-5624-6267</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1541-4337 |
| ispartof | Comprehensive reviews in food science and food safety, 2022-11, Vol.21 (6), p.4509-4545 |
| issn | 1541-4337 1541-4337 |
| language | eng |
| recordid | cdi_proquest_journals_2738971825 |
| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | (poly)phenol metabolism Animals Bioavailability Biological Availability Catabolites Citrus citrus fruits Food processing Gene polymorphism gut microbiome Humans interindividual variation Intestinal microflora Microbiota Phenol Phenols Polyphenols |
| title | Review of factors affecting citrus polyphenol bioavailability and their importance in designing in vitro, animal, and intervention studies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T03%3A00%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Review%20of%20factors%20affecting%20citrus%20polyphenol%20bioavailability%20and%20their%20importance%20in%20designing%20in%20vitro,%20animal,%20and%20intervention%20studies&rft.jtitle=Comprehensive%20reviews%20in%20food%20science%20and%20food%20safety&rft.au=Visvanathan,%20Rizliya&rft.date=2022-11&rft.volume=21&rft.issue=6&rft.spage=4509&rft.epage=4545&rft.pages=4509-4545&rft.issn=1541-4337&rft.eissn=1541-4337&rft_id=info:doi/10.1111/1541-4337.13057&rft_dat=%3Cproquest_cross%3E2738971825%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2738971825&rft_id=info:pmid/36183163&rfr_iscdi=true |