Association between cardiorespiratory fitness and colorectal cancer in the UK Biobank
Increased cardiorespiratory fitness is related to decreased risk of major chronic illnesses, including cardiovascular disease, type 2 diabetes, and cancer, but its association with colorectal cancer specifically has received very little attention. We examined the relation of cardiorespiratory fitnes...
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| Veröffentlicht in: | European journal of epidemiology 2020-10, Vol.35 (10), p.961-973 |
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| creator | Hillreiner, Andrea Baumeister, Sebastian E. Sedlmeier, Anja M. Finger, Jonas D. Schlitt, Hans J. Leitzmann, Michael F. |
| description | Increased cardiorespiratory fitness is related to decreased risk of major chronic illnesses, including cardiovascular disease, type 2 diabetes, and cancer, but its association with colorectal cancer specifically has received very little attention. We examined the relation of cardiorespiratory fitness to colorectal cancer in 59,191 UK Biobank participants aged 39–70 years without prevalent cancer at baseline, followed from 2009 to 2014. Submaximal bicycle ergometry was conducted at study entry, and cardiorespiratory fitness was defined as physical work capacity at 75% of the maximum heart rate, standardised to body mass (PWC
75%
). Multivariable Cox proportional hazards regression was performed to obtain hazard ratios (HR) and corresponding 95% confidence intervals (CI). During a mean follow-up of 4.6 years, 232 participants developed colorectal cancer (151 colon cancers; 79 rectal cancers). When comparing the 75th to the 25th percentiles of PWC
75%
, the multivariable-adjusted HR of colorectal cancer was 0.78 (95% CI 0.62–0.97). That relation was largely driven by an inverse association with colon cancer (HR 0.74, 95% CI 0.56–0.97) and less so with rectal cancer (HR 0.88, 95% CI 0.62–1.26;
p
value for difference by colorectal cancer endpoint = 0.056). The inverse relation of cardiorespiratory fitness with colorectal cancer was more evident in men (HR 0.72, 95% CI 0.55–0.94) than women (HR 0.99, 95% CI 0.71–1.38), although the gender difference was not statistically significant (
p
value for interaction = 0.192). Increased cardiorespiratory fitness is associated with decreased risk of colorectal cancer. Potential heterogeneity by colorectal cancer anatomic subsite and gender requires further study. |
| doi_str_mv | 10.1007/s10654-019-00575-6 |
| format | Article |
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75%
). Multivariable Cox proportional hazards regression was performed to obtain hazard ratios (HR) and corresponding 95% confidence intervals (CI). During a mean follow-up of 4.6 years, 232 participants developed colorectal cancer (151 colon cancers; 79 rectal cancers). When comparing the 75th to the 25th percentiles of PWC
75%
, the multivariable-adjusted HR of colorectal cancer was 0.78 (95% CI 0.62–0.97). That relation was largely driven by an inverse association with colon cancer (HR 0.74, 95% CI 0.56–0.97) and less so with rectal cancer (HR 0.88, 95% CI 0.62–1.26;
p
value for difference by colorectal cancer endpoint = 0.056). The inverse relation of cardiorespiratory fitness with colorectal cancer was more evident in men (HR 0.72, 95% CI 0.55–0.94) than women (HR 0.99, 95% CI 0.71–1.38), although the gender difference was not statistically significant (
p
value for interaction = 0.192). Increased cardiorespiratory fitness is associated with decreased risk of colorectal cancer. Potential heterogeneity by colorectal cancer anatomic subsite and gender requires further study.</description><identifier>ISSN: 0393-2990</identifier><identifier>EISSN: 1573-7284</identifier><identifier>DOI: 10.1007/s10654-019-00575-6</identifier><identifier>PMID: 31707551</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adult ; Aged ; Bicycles ; Biobanks ; Biological Specimen Banks ; Body mass ; Body Mass Index ; Cancer ; Cardiology ; Cardiorespiratory Fitness ; Cardiovascular diseases ; Cohort Studies ; Colon ; Colon cancer ; Colonic Neoplasms - diagnosis ; Colonic Neoplasms - epidemiology ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - epidemiology ; Confidence intervals ; Diabetes mellitus (non-insulin dependent) ; Epidemiology ; Exercise Test ; Female ; Fitness ; Gender ; Heart rate ; Heart Rate - physiology ; Heterogeneity ; Humans ; Infectious Diseases ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncology ; Physical work ; Proportional Hazards Models ; Prospective Studies ; Public Health ; Rectal Neoplasms - diagnosis ; Rectal Neoplasms - epidemiology ; Rectum ; Sex Factors ; Statistical analysis ; United Kingdom - epidemiology ; Work capacity</subject><ispartof>European journal of epidemiology, 2020-10, Vol.35 (10), p.961-973</ispartof><rights>Springer Nature B.V. 2019</rights><rights>Springer Nature B.V. 2019.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-5ada8441126874c07675e86b3c6ca6f0f2a115d328744da3e68444d2e5be4e5d3</citedby><cites>FETCH-LOGICAL-c419t-5ada8441126874c07675e86b3c6ca6f0f2a115d328744da3e68444d2e5be4e5d3</cites><orcidid>0000-0002-4777-7808 ; 0000-0002-7564-3065</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10654-019-00575-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10654-019-00575-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31707551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hillreiner, Andrea</creatorcontrib><creatorcontrib>Baumeister, Sebastian E.</creatorcontrib><creatorcontrib>Sedlmeier, Anja M.</creatorcontrib><creatorcontrib>Finger, Jonas D.</creatorcontrib><creatorcontrib>Schlitt, Hans J.</creatorcontrib><creatorcontrib>Leitzmann, Michael F.</creatorcontrib><title>Association between cardiorespiratory fitness and colorectal cancer in the UK Biobank</title><title>European journal of epidemiology</title><addtitle>Eur J Epidemiol</addtitle><addtitle>Eur J Epidemiol</addtitle><description>Increased cardiorespiratory fitness is related to decreased risk of major chronic illnesses, including cardiovascular disease, type 2 diabetes, and cancer, but its association with colorectal cancer specifically has received very little attention. We examined the relation of cardiorespiratory fitness to colorectal cancer in 59,191 UK Biobank participants aged 39–70 years without prevalent cancer at baseline, followed from 2009 to 2014. Submaximal bicycle ergometry was conducted at study entry, and cardiorespiratory fitness was defined as physical work capacity at 75% of the maximum heart rate, standardised to body mass (PWC
75%
). Multivariable Cox proportional hazards regression was performed to obtain hazard ratios (HR) and corresponding 95% confidence intervals (CI). During a mean follow-up of 4.6 years, 232 participants developed colorectal cancer (151 colon cancers; 79 rectal cancers). When comparing the 75th to the 25th percentiles of PWC
75%
, the multivariable-adjusted HR of colorectal cancer was 0.78 (95% CI 0.62–0.97). That relation was largely driven by an inverse association with colon cancer (HR 0.74, 95% CI 0.56–0.97) and less so with rectal cancer (HR 0.88, 95% CI 0.62–1.26;
p
value for difference by colorectal cancer endpoint = 0.056). The inverse relation of cardiorespiratory fitness with colorectal cancer was more evident in men (HR 0.72, 95% CI 0.55–0.94) than women (HR 0.99, 95% CI 0.71–1.38), although the gender difference was not statistically significant (
p
value for interaction = 0.192). Increased cardiorespiratory fitness is associated with decreased risk of colorectal cancer. Potential heterogeneity by colorectal cancer anatomic subsite and gender requires further study.</description><subject>Adult</subject><subject>Aged</subject><subject>Bicycles</subject><subject>Biobanks</subject><subject>Biological Specimen Banks</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Cancer</subject><subject>Cardiology</subject><subject>Cardiorespiratory Fitness</subject><subject>Cardiovascular diseases</subject><subject>Cohort Studies</subject><subject>Colon</subject><subject>Colon cancer</subject><subject>Colonic Neoplasms - diagnosis</subject><subject>Colonic Neoplasms - epidemiology</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Colorectal Neoplasms - epidemiology</subject><subject>Confidence intervals</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Epidemiology</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Fitness</subject><subject>Gender</subject><subject>Heart rate</subject><subject>Heart Rate - physiology</subject><subject>Heterogeneity</subject><subject>Humans</subject><subject>Infectious Diseases</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Physical work</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Public Health</subject><subject>Rectal Neoplasms - diagnosis</subject><subject>Rectal Neoplasms - epidemiology</subject><subject>Rectum</subject><subject>Sex Factors</subject><subject>Statistical analysis</subject><subject>United Kingdom - epidemiology</subject><subject>Work capacity</subject><issn>0393-2990</issn><issn>1573-7284</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwAyyQJdaBcfxKlgXxEkhs6NpynAmktHaxUyH-HkML7FjN4p57RzqEHDM4YwD6PDFQUhTA6gJAalmoHTJmUvNCl5XYJWPgNS_KuoYROUhpDgAV1HKfjDjToKVkYzKbphRcb4c-eNrg8I7oqbOx7UPEtOqjHUL8oF0_eEyJWt9SFxY5c4NdZNA7jLT3dHhBOrunF31orH89JHudXSQ82t4JmV1fPV3eFg-PN3eX04fCCVYPhbStrYRgrFSVFg600hIr1XCnnFUddKVlTLa8zKloLUeVadGWKBsUmIMJOd3srmJ4W2MazDyso88vTam5lnWlVZ2pckO5GFKK2JlV7Jc2fhgG5suk2Zg02aT5NmlULp1sp9fNEtvfyo-6DPANkHLknzH-_f5n9hNflH5L</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Hillreiner, Andrea</creator><creator>Baumeister, Sebastian E.</creator><creator>Sedlmeier, Anja M.</creator><creator>Finger, Jonas D.</creator><creator>Schlitt, Hans J.</creator><creator>Leitzmann, Michael F.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0002-4777-7808</orcidid><orcidid>https://orcid.org/0000-0002-7564-3065</orcidid></search><sort><creationdate>20201001</creationdate><title>Association between cardiorespiratory fitness and colorectal cancer in the UK Biobank</title><author>Hillreiner, Andrea ; Baumeister, Sebastian E. ; Sedlmeier, Anja M. ; Finger, Jonas D. ; Schlitt, Hans J. ; Leitzmann, Michael F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-5ada8441126874c07675e86b3c6ca6f0f2a115d328744da3e68444d2e5be4e5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Bicycles</topic><topic>Biobanks</topic><topic>Biological Specimen Banks</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Cancer</topic><topic>Cardiology</topic><topic>Cardiorespiratory Fitness</topic><topic>Cardiovascular diseases</topic><topic>Cohort Studies</topic><topic>Colon</topic><topic>Colon cancer</topic><topic>Colonic Neoplasms - diagnosis</topic><topic>Colonic Neoplasms - epidemiology</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - diagnosis</topic><topic>Colorectal Neoplasms - epidemiology</topic><topic>Confidence intervals</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Epidemiology</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Fitness</topic><topic>Gender</topic><topic>Heart rate</topic><topic>Heart Rate - physiology</topic><topic>Heterogeneity</topic><topic>Humans</topic><topic>Infectious Diseases</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Physical work</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Public Health</topic><topic>Rectal Neoplasms - diagnosis</topic><topic>Rectal Neoplasms - epidemiology</topic><topic>Rectum</topic><topic>Sex Factors</topic><topic>Statistical analysis</topic><topic>United Kingdom - epidemiology</topic><topic>Work capacity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hillreiner, Andrea</creatorcontrib><creatorcontrib>Baumeister, Sebastian E.</creatorcontrib><creatorcontrib>Sedlmeier, Anja M.</creatorcontrib><creatorcontrib>Finger, Jonas D.</creatorcontrib><creatorcontrib>Schlitt, Hans J.</creatorcontrib><creatorcontrib>Leitzmann, Michael F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>European journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hillreiner, Andrea</au><au>Baumeister, Sebastian E.</au><au>Sedlmeier, Anja M.</au><au>Finger, Jonas D.</au><au>Schlitt, Hans J.</au><au>Leitzmann, Michael F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between cardiorespiratory fitness and colorectal cancer in the UK Biobank</atitle><jtitle>European journal of epidemiology</jtitle><stitle>Eur J Epidemiol</stitle><addtitle>Eur J Epidemiol</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>35</volume><issue>10</issue><spage>961</spage><epage>973</epage><pages>961-973</pages><issn>0393-2990</issn><eissn>1573-7284</eissn><abstract>Increased cardiorespiratory fitness is related to decreased risk of major chronic illnesses, including cardiovascular disease, type 2 diabetes, and cancer, but its association with colorectal cancer specifically has received very little attention. We examined the relation of cardiorespiratory fitness to colorectal cancer in 59,191 UK Biobank participants aged 39–70 years without prevalent cancer at baseline, followed from 2009 to 2014. Submaximal bicycle ergometry was conducted at study entry, and cardiorespiratory fitness was defined as physical work capacity at 75% of the maximum heart rate, standardised to body mass (PWC
75%
). Multivariable Cox proportional hazards regression was performed to obtain hazard ratios (HR) and corresponding 95% confidence intervals (CI). During a mean follow-up of 4.6 years, 232 participants developed colorectal cancer (151 colon cancers; 79 rectal cancers). When comparing the 75th to the 25th percentiles of PWC
75%
, the multivariable-adjusted HR of colorectal cancer was 0.78 (95% CI 0.62–0.97). That relation was largely driven by an inverse association with colon cancer (HR 0.74, 95% CI 0.56–0.97) and less so with rectal cancer (HR 0.88, 95% CI 0.62–1.26;
p
value for difference by colorectal cancer endpoint = 0.056). The inverse relation of cardiorespiratory fitness with colorectal cancer was more evident in men (HR 0.72, 95% CI 0.55–0.94) than women (HR 0.99, 95% CI 0.71–1.38), although the gender difference was not statistically significant (
p
value for interaction = 0.192). Increased cardiorespiratory fitness is associated with decreased risk of colorectal cancer. Potential heterogeneity by colorectal cancer anatomic subsite and gender requires further study.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>31707551</pmid><doi>10.1007/s10654-019-00575-6</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-4777-7808</orcidid><orcidid>https://orcid.org/0000-0002-7564-3065</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Bicycles Biobanks Biological Specimen Banks Body mass Body Mass Index Cancer Cardiology Cardiorespiratory Fitness Cardiovascular diseases Cohort Studies Colon Colon cancer Colonic Neoplasms - diagnosis Colonic Neoplasms - epidemiology Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - diagnosis Colorectal Neoplasms - epidemiology Confidence intervals Diabetes mellitus (non-insulin dependent) Epidemiology Exercise Test Female Fitness Gender Heart rate Heart Rate - physiology Heterogeneity Humans Infectious Diseases Male Medicine Medicine & Public Health Middle Aged Oncology Physical work Proportional Hazards Models Prospective Studies Public Health Rectal Neoplasms - diagnosis Rectal Neoplasms - epidemiology Rectum Sex Factors Statistical analysis United Kingdom - epidemiology Work capacity |
| title | Association between cardiorespiratory fitness and colorectal cancer in the UK Biobank |
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