Consistency and prognostic value of preoperative staging and postoperative pathological staging using18F-FDG PET/MRI in patients with non-small cell lung cancer
Objective In recent years, positron emission tomography/magnetic resonance imaging (PET/MRI) has been clinically used as a method to diagnose non-small cell lung cancer (NSCLC). This study aimed to evaluate the concordance of staging and prognostic ability of NSCLC patients using thin-slice computed...
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| Veröffentlicht in: | Annals of nuclear medicine 2022, Vol.36 (12), p.1059-1072 |
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| creator | Kajiyama, Akiko Ito, Kimiteru Watanabe, Hirokazu Mizumura, Sunao Watanabe, Shun-ichi Yatabe, Yasushi Gomi, Tatsuya Kusumoto, Masahiko |
| description | Objective
In recent years, positron emission tomography/magnetic resonance imaging (PET/MRI) has been clinically used as a method to diagnose non-small cell lung cancer (NSCLC). This study aimed to evaluate the concordance of staging and prognostic ability of NSCLC patients using thin-slice computed tomography (CT) and
18
F-fluorodeoxyglucose (FDG) PET/MRI.
Methods
This retrospective study was performed on consecutive NSCLC patients who underwent both diagnostic CT and
18
F-FDG PET/MRI before surgery between November 2015 and May 2019. The cTNM staging yielded from PET/MRI was compared with CT and pathological staging, and concordance was investigated, defining pathological findings as reference. To assess the prognostic value of disease-free survival (DFS) and overall survival (OS), we dichotomized the typical prognostic factors and TNM classification staging (Stage I vs. Stage II or higher). Kaplan–Meier curves derived by the log-rank test were generated, and univariate and multivariate analyses were performed to identify the factors associated with DFS and OS.
Results
A total of 82 subjects were included; PET/MRI staging was more consistent (59 of 82) with pathological staging than with CT staging. There was a total of 21 cases of CT and 11 cases of PET/MRI that were judged as cStage I, but were actually pStage II or pStage III. CT tended to judge pN1 or pN2 as cN0 compared to PET/MRI. There was a significant difference between NSCLC patients with Stage I and Stage II or higher by PET/MRI staging as well as prognosis prediction of DFS by pathological staging (
P
|
| doi_str_mv | 10.1007/s12149-022-01795-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_sprin</sourceid><recordid>TN_cdi_proquest_journals_2737134984</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2737134984</sourcerecordid><originalsourceid>FETCH-LOGICAL-p729-d1085c85bcb03ab74decd2c07eec7888a473625012b99fb3561c1208d2f2eac93</originalsourceid><addsrcrecordid>eNpFkd9KwzAUxoMoOKcv4FXA67j8a5NcytzmYKLI7kuapl1HTWrTTnwbH9XMirv5DpzzO-fw8QFwS_A9wVjMAqGEK4QpRZgIlSB1BiZEphylnLFzMMGKcCSIFJfgKoQ9xlQmkk7A99y7UIfeOvMFtStg2_nK-dDXBh50M1joy9izvrWd7uuDhaHXVe2qEY7gadLqfucbX9VGN__YEKISuUTLxxV8XWxnz29rWLsjXFvXB_hZ9zvovEPhXTcNNDZKM8RNo52x3TW4KHUT7M1fnYLtcrGdP6HNy2o9f9igVlCFCoJlYmSSmxwznQteWFNQg4W1RkgpNRcspQkmNFeqzFmSEkMolgUtqdVGsSm4G89G_x-DDX2290Pn4seMCiYI40rySLGRCm0XbdnuRBGcHZPIxiSymET2m0Sm2A_AGX7f</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2737134984</pqid></control><display><type>article</type><title>Consistency and prognostic value of preoperative staging and postoperative pathological staging using18F-FDG PET/MRI in patients with non-small cell lung cancer</title><source>SpringerLink Journals - AutoHoldings</source><creator>Kajiyama, Akiko ; Ito, Kimiteru ; Watanabe, Hirokazu ; Mizumura, Sunao ; Watanabe, Shun-ichi ; Yatabe, Yasushi ; Gomi, Tatsuya ; Kusumoto, Masahiko</creator><creatorcontrib>Kajiyama, Akiko ; Ito, Kimiteru ; Watanabe, Hirokazu ; Mizumura, Sunao ; Watanabe, Shun-ichi ; Yatabe, Yasushi ; Gomi, Tatsuya ; Kusumoto, Masahiko</creatorcontrib><description>Objective
In recent years, positron emission tomography/magnetic resonance imaging (PET/MRI) has been clinically used as a method to diagnose non-small cell lung cancer (NSCLC). This study aimed to evaluate the concordance of staging and prognostic ability of NSCLC patients using thin-slice computed tomography (CT) and
18
F-fluorodeoxyglucose (FDG) PET/MRI.
Methods
This retrospective study was performed on consecutive NSCLC patients who underwent both diagnostic CT and
18
F-FDG PET/MRI before surgery between November 2015 and May 2019. The cTNM staging yielded from PET/MRI was compared with CT and pathological staging, and concordance was investigated, defining pathological findings as reference. To assess the prognostic value of disease-free survival (DFS) and overall survival (OS), we dichotomized the typical prognostic factors and TNM classification staging (Stage I vs. Stage II or higher). Kaplan–Meier curves derived by the log-rank test were generated, and univariate and multivariate analyses were performed to identify the factors associated with DFS and OS.
Results
A total of 82 subjects were included; PET/MRI staging was more consistent (59 of 82) with pathological staging than with CT staging. There was a total of 21 cases of CT and 11 cases of PET/MRI that were judged as cStage I, but were actually pStage II or pStage III. CT tended to judge pN1 or pN2 as cN0 compared to PET/MRI. There was a significant difference between NSCLC patients with Stage I and Stage II or higher by PET/MRI staging as well as prognosis prediction of DFS by pathological staging (
P
< 0.001). In univariate analysis, PET/MRI, CT, and pathological staging (Stage I or lower vs. Stage II or higher) all showed significant differences as prognostic factors of recurrence or metastases. In multivariate analysis, pathological staging was the only independent factor for recurrence (
P
= 0.009), and preoperative PET/MRI staging was a predictor of patient survival (
P
= 0.013).
Conclusions
In NSCLC, pathologic staging was better at predicting recurrence, and preoperative PET/MRI staging was better at predicting survival. Preoperative staging by PET/MRI was superior to CT in diagnosing hilar and mediastinal lymph-node metastases, which contributed to the high concordance with pathologic staging.</description><identifier>ISSN: 0914-7187</identifier><identifier>EISSN: 1864-6433</identifier><identifier>DOI: 10.1007/s12149-022-01795-9</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Computed tomography ; Fluorine isotopes ; Imaging ; Lung cancer ; Magnetic resonance imaging ; Medical prognosis ; Medicine ; Medicine & Public Health ; Metastases ; Metastasis ; Multivariate analysis ; Non-small cell lung carcinoma ; Nuclear Medicine ; Original Article ; Patients ; Positron emission ; Positron emission tomography ; Radiology ; Rank tests ; Small cell lung carcinoma ; Survival ; Tomography</subject><ispartof>Annals of nuclear medicine, 2022, Vol.36 (12), p.1059-1072</ispartof><rights>The Author(s) under exclusive licence to The Japanese Society of Nuclear Medicine 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-0905-6767</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12149-022-01795-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12149-022-01795-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids></links><search><creatorcontrib>Kajiyama, Akiko</creatorcontrib><creatorcontrib>Ito, Kimiteru</creatorcontrib><creatorcontrib>Watanabe, Hirokazu</creatorcontrib><creatorcontrib>Mizumura, Sunao</creatorcontrib><creatorcontrib>Watanabe, Shun-ichi</creatorcontrib><creatorcontrib>Yatabe, Yasushi</creatorcontrib><creatorcontrib>Gomi, Tatsuya</creatorcontrib><creatorcontrib>Kusumoto, Masahiko</creatorcontrib><title>Consistency and prognostic value of preoperative staging and postoperative pathological staging using18F-FDG PET/MRI in patients with non-small cell lung cancer</title><title>Annals of nuclear medicine</title><addtitle>Ann Nucl Med</addtitle><description>Objective
In recent years, positron emission tomography/magnetic resonance imaging (PET/MRI) has been clinically used as a method to diagnose non-small cell lung cancer (NSCLC). This study aimed to evaluate the concordance of staging and prognostic ability of NSCLC patients using thin-slice computed tomography (CT) and
18
F-fluorodeoxyglucose (FDG) PET/MRI.
Methods
This retrospective study was performed on consecutive NSCLC patients who underwent both diagnostic CT and
18
F-FDG PET/MRI before surgery between November 2015 and May 2019. The cTNM staging yielded from PET/MRI was compared with CT and pathological staging, and concordance was investigated, defining pathological findings as reference. To assess the prognostic value of disease-free survival (DFS) and overall survival (OS), we dichotomized the typical prognostic factors and TNM classification staging (Stage I vs. Stage II or higher). Kaplan–Meier curves derived by the log-rank test were generated, and univariate and multivariate analyses were performed to identify the factors associated with DFS and OS.
Results
A total of 82 subjects were included; PET/MRI staging was more consistent (59 of 82) with pathological staging than with CT staging. There was a total of 21 cases of CT and 11 cases of PET/MRI that were judged as cStage I, but were actually pStage II or pStage III. CT tended to judge pN1 or pN2 as cN0 compared to PET/MRI. There was a significant difference between NSCLC patients with Stage I and Stage II or higher by PET/MRI staging as well as prognosis prediction of DFS by pathological staging (
P
< 0.001). In univariate analysis, PET/MRI, CT, and pathological staging (Stage I or lower vs. Stage II or higher) all showed significant differences as prognostic factors of recurrence or metastases. In multivariate analysis, pathological staging was the only independent factor for recurrence (
P
= 0.009), and preoperative PET/MRI staging was a predictor of patient survival (
P
= 0.013).
Conclusions
In NSCLC, pathologic staging was better at predicting recurrence, and preoperative PET/MRI staging was better at predicting survival. Preoperative staging by PET/MRI was superior to CT in diagnosing hilar and mediastinal lymph-node metastases, which contributed to the high concordance with pathologic staging.</description><subject>Computed tomography</subject><subject>Fluorine isotopes</subject><subject>Imaging</subject><subject>Lung cancer</subject><subject>Magnetic resonance imaging</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Multivariate analysis</subject><subject>Non-small cell lung carcinoma</subject><subject>Nuclear Medicine</subject><subject>Original Article</subject><subject>Patients</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Radiology</subject><subject>Rank tests</subject><subject>Small cell lung carcinoma</subject><subject>Survival</subject><subject>Tomography</subject><issn>0914-7187</issn><issn>1864-6433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpFkd9KwzAUxoMoOKcv4FXA67j8a5NcytzmYKLI7kuapl1HTWrTTnwbH9XMirv5DpzzO-fw8QFwS_A9wVjMAqGEK4QpRZgIlSB1BiZEphylnLFzMMGKcCSIFJfgKoQ9xlQmkk7A99y7UIfeOvMFtStg2_nK-dDXBh50M1joy9izvrWd7uuDhaHXVe2qEY7gadLqfucbX9VGN__YEKISuUTLxxV8XWxnz29rWLsjXFvXB_hZ9zvovEPhXTcNNDZKM8RNo52x3TW4KHUT7M1fnYLtcrGdP6HNy2o9f9igVlCFCoJlYmSSmxwznQteWFNQg4W1RkgpNRcspQkmNFeqzFmSEkMolgUtqdVGsSm4G89G_x-DDX2290Pn4seMCiYI40rySLGRCm0XbdnuRBGcHZPIxiSymET2m0Sm2A_AGX7f</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Kajiyama, Akiko</creator><creator>Ito, Kimiteru</creator><creator>Watanabe, Hirokazu</creator><creator>Mizumura, Sunao</creator><creator>Watanabe, Shun-ichi</creator><creator>Yatabe, Yasushi</creator><creator>Gomi, Tatsuya</creator><creator>Kusumoto, Masahiko</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><orcidid>https://orcid.org/0000-0003-0905-6767</orcidid></search><sort><creationdate>2022</creationdate><title>Consistency and prognostic value of preoperative staging and postoperative pathological staging using18F-FDG PET/MRI in patients with non-small cell lung cancer</title><author>Kajiyama, Akiko ; Ito, Kimiteru ; Watanabe, Hirokazu ; Mizumura, Sunao ; Watanabe, Shun-ichi ; Yatabe, Yasushi ; Gomi, Tatsuya ; Kusumoto, Masahiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p729-d1085c85bcb03ab74decd2c07eec7888a473625012b99fb3561c1208d2f2eac93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Computed tomography</topic><topic>Fluorine isotopes</topic><topic>Imaging</topic><topic>Lung cancer</topic><topic>Magnetic resonance imaging</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Multivariate analysis</topic><topic>Non-small cell lung carcinoma</topic><topic>Nuclear Medicine</topic><topic>Original Article</topic><topic>Patients</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Radiology</topic><topic>Rank tests</topic><topic>Small cell lung carcinoma</topic><topic>Survival</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kajiyama, Akiko</creatorcontrib><creatorcontrib>Ito, Kimiteru</creatorcontrib><creatorcontrib>Watanabe, Hirokazu</creatorcontrib><creatorcontrib>Mizumura, Sunao</creatorcontrib><creatorcontrib>Watanabe, Shun-ichi</creatorcontrib><creatorcontrib>Yatabe, Yasushi</creatorcontrib><creatorcontrib>Gomi, Tatsuya</creatorcontrib><creatorcontrib>Kusumoto, Masahiko</creatorcontrib><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Annals of nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kajiyama, Akiko</au><au>Ito, Kimiteru</au><au>Watanabe, Hirokazu</au><au>Mizumura, Sunao</au><au>Watanabe, Shun-ichi</au><au>Yatabe, Yasushi</au><au>Gomi, Tatsuya</au><au>Kusumoto, Masahiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Consistency and prognostic value of preoperative staging and postoperative pathological staging using18F-FDG PET/MRI in patients with non-small cell lung cancer</atitle><jtitle>Annals of nuclear medicine</jtitle><stitle>Ann Nucl Med</stitle><date>2022</date><risdate>2022</risdate><volume>36</volume><issue>12</issue><spage>1059</spage><epage>1072</epage><pages>1059-1072</pages><issn>0914-7187</issn><eissn>1864-6433</eissn><abstract>Objective
In recent years, positron emission tomography/magnetic resonance imaging (PET/MRI) has been clinically used as a method to diagnose non-small cell lung cancer (NSCLC). This study aimed to evaluate the concordance of staging and prognostic ability of NSCLC patients using thin-slice computed tomography (CT) and
18
F-fluorodeoxyglucose (FDG) PET/MRI.
Methods
This retrospective study was performed on consecutive NSCLC patients who underwent both diagnostic CT and
18
F-FDG PET/MRI before surgery between November 2015 and May 2019. The cTNM staging yielded from PET/MRI was compared with CT and pathological staging, and concordance was investigated, defining pathological findings as reference. To assess the prognostic value of disease-free survival (DFS) and overall survival (OS), we dichotomized the typical prognostic factors and TNM classification staging (Stage I vs. Stage II or higher). Kaplan–Meier curves derived by the log-rank test were generated, and univariate and multivariate analyses were performed to identify the factors associated with DFS and OS.
Results
A total of 82 subjects were included; PET/MRI staging was more consistent (59 of 82) with pathological staging than with CT staging. There was a total of 21 cases of CT and 11 cases of PET/MRI that were judged as cStage I, but were actually pStage II or pStage III. CT tended to judge pN1 or pN2 as cN0 compared to PET/MRI. There was a significant difference between NSCLC patients with Stage I and Stage II or higher by PET/MRI staging as well as prognosis prediction of DFS by pathological staging (
P
< 0.001). In univariate analysis, PET/MRI, CT, and pathological staging (Stage I or lower vs. Stage II or higher) all showed significant differences as prognostic factors of recurrence or metastases. In multivariate analysis, pathological staging was the only independent factor for recurrence (
P
= 0.009), and preoperative PET/MRI staging was a predictor of patient survival (
P
= 0.013).
Conclusions
In NSCLC, pathologic staging was better at predicting recurrence, and preoperative PET/MRI staging was better at predicting survival. Preoperative staging by PET/MRI was superior to CT in diagnosing hilar and mediastinal lymph-node metastases, which contributed to the high concordance with pathologic staging.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><doi>10.1007/s12149-022-01795-9</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-0905-6767</orcidid></addata></record> |
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| subjects | Computed tomography Fluorine isotopes Imaging Lung cancer Magnetic resonance imaging Medical prognosis Medicine Medicine & Public Health Metastases Metastasis Multivariate analysis Non-small cell lung carcinoma Nuclear Medicine Original Article Patients Positron emission Positron emission tomography Radiology Rank tests Small cell lung carcinoma Survival Tomography |
| title | Consistency and prognostic value of preoperative staging and postoperative pathological staging using18F-FDG PET/MRI in patients with non-small cell lung cancer |
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