Netrin-1 and Cyclophilin A : biomarkers of inflammation and kidney injury in Alport syndrome: a pilot study
Background: Netrin-1 and Cyclophilin A (CypA) participate in the pathological processes of inflammation, oxidative stress and apoptosis. Our objective was to determine the level of serum Netrin-1 & Cyclophilin A (CypA) in Alport syndrome. Materials and Methods: The study included 10 Alport syndr...
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| Veröffentlicht in: | New Zealand journal of medical laboratory science 2022-11, Vol.76 (3), p.50-52 |
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| container_title | New Zealand journal of medical laboratory science |
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| creator | Zaki, Moushira Fadel, Fatina I Toukhy, Safinaz Ebrahim El Youness, Eman R Selim, Abeer Sonbaty, Mohamed El Bassyouni, Hala T. El |
| description | Background: Netrin-1 and Cyclophilin A (CypA) participate in the pathological processes of inflammation, oxidative stress and apoptosis. Our objective was to determine the level of serum Netrin-1 & Cyclophilin A (CypA) in Alport syndrome. Materials and Methods: The study included 10 Alport syndrome patients, their age ranged from 5-13 years (8.50[+ or - ]2.87) (mean age [+ or -]SD), they were 7 females and 3 males (ratio of 1:0.43) and 10 age and sex matched healthy children. Serum Netrin-1 and Cyclophilin A (CypA) were measured using ELISA kits. Results: All patients presented with haematuria, while 3 cases had mild proteinuria. The renal pathology revealed features like thin basement membrane disease. Sensorineural hearing loss was present in 8 patients and no patients had retinitis pigmentosa. The serum levels of Netrin-1 were 160.47ng/mL [+ or -] 12.833 for controls and 141.91ng/mL [+ or -]16.953 for patients (p < 0.01), for CypA was 7.55ng/mL [+ or -]0.74 in patients compared to 6.27ng/mL [+ or -]0.37 in controls (p |
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El</creator><creatorcontrib>Zaki, Moushira ; Fadel, Fatina I ; Toukhy, Safinaz Ebrahim El ; Youness, Eman R ; Selim, Abeer ; Sonbaty, Mohamed El ; Bassyouni, Hala T. El</creatorcontrib><description>Background: Netrin-1 and Cyclophilin A (CypA) participate in the pathological processes of inflammation, oxidative stress and apoptosis. Our objective was to determine the level of serum Netrin-1 & Cyclophilin A (CypA) in Alport syndrome. Materials and Methods: The study included 10 Alport syndrome patients, their age ranged from 5-13 years (8.50[+ or - ]2.87) (mean age [+ or -]SD), they were 7 females and 3 males (ratio of 1:0.43) and 10 age and sex matched healthy children. Serum Netrin-1 and Cyclophilin A (CypA) were measured using ELISA kits. Results: All patients presented with haematuria, while 3 cases had mild proteinuria. The renal pathology revealed features like thin basement membrane disease. Sensorineural hearing loss was present in 8 patients and no patients had retinitis pigmentosa. The serum levels of Netrin-1 were 160.47ng/mL [+ or -] 12.833 for controls and 141.91ng/mL [+ or -]16.953 for patients (p < 0.01), for CypA was 7.55ng/mL [+ or -]0.74 in patients compared to 6.27ng/mL [+ or -]0.37 in controls (p<0.001). Conclusion: To the best of our knowledge, this is the first research to investigate the levels of Netrin-1 and Cyclophilin A in Alport syndrome patients. Keywords: Alport syndrome, Cyclophilin A (CypA), Netrin-1, inflammation. N Z J Med Lab Sci 2022; 76(3): 136-138</description><identifier>ISSN: 1171-0195</identifier><language>eng</language><publisher>Auckland: New Zealand Institute of Medical Laboratory Science</publisher><subject>Age ; Apoptosis ; Biomarkers ; Hearing loss ; Hematuria ; Inflammation ; Kidney diseases ; Medical research ; Medicine, Experimental ; Mutation ; Oxidative stress ; Pathology ; Pediatrics ; Research centers</subject><ispartof>New Zealand journal of medical laboratory science, 2022-11, Vol.76 (3), p.50-52</ispartof><rights>COPYRIGHT 2022 New Zealand Institute of Medical Laboratory Science</rights><rights>Copyright New Zealand Institute of Medical Laboratory Science Nov 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Zaki, Moushira</creatorcontrib><creatorcontrib>Fadel, Fatina I</creatorcontrib><creatorcontrib>Toukhy, Safinaz Ebrahim El</creatorcontrib><creatorcontrib>Youness, Eman R</creatorcontrib><creatorcontrib>Selim, Abeer</creatorcontrib><creatorcontrib>Sonbaty, Mohamed El</creatorcontrib><creatorcontrib>Bassyouni, Hala T. El</creatorcontrib><title>Netrin-1 and Cyclophilin A : biomarkers of inflammation and kidney injury in Alport syndrome: a pilot study</title><title>New Zealand journal of medical laboratory science</title><description>Background: Netrin-1 and Cyclophilin A (CypA) participate in the pathological processes of inflammation, oxidative stress and apoptosis. Our objective was to determine the level of serum Netrin-1 & Cyclophilin A (CypA) in Alport syndrome. Materials and Methods: The study included 10 Alport syndrome patients, their age ranged from 5-13 years (8.50[+ or - ]2.87) (mean age [+ or -]SD), they were 7 females and 3 males (ratio of 1:0.43) and 10 age and sex matched healthy children. Serum Netrin-1 and Cyclophilin A (CypA) were measured using ELISA kits. Results: All patients presented with haematuria, while 3 cases had mild proteinuria. The renal pathology revealed features like thin basement membrane disease. Sensorineural hearing loss was present in 8 patients and no patients had retinitis pigmentosa. The serum levels of Netrin-1 were 160.47ng/mL [+ or -] 12.833 for controls and 141.91ng/mL [+ or -]16.953 for patients (p < 0.01), for CypA was 7.55ng/mL [+ or -]0.74 in patients compared to 6.27ng/mL [+ or -]0.37 in controls (p<0.001). Conclusion: To the best of our knowledge, this is the first research to investigate the levels of Netrin-1 and Cyclophilin A in Alport syndrome patients. Keywords: Alport syndrome, Cyclophilin A (CypA), Netrin-1, inflammation. N Z J Med Lab Sci 2022; 76(3): 136-138</description><subject>Age</subject><subject>Apoptosis</subject><subject>Biomarkers</subject><subject>Hearing loss</subject><subject>Hematuria</subject><subject>Inflammation</subject><subject>Kidney diseases</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mutation</subject><subject>Oxidative stress</subject><subject>Pathology</subject><subject>Pediatrics</subject><subject>Research centers</subject><issn>1171-0195</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptj8tqwzAQRb1ooenjHwRdu-gRS3J2JvQFod1kb2RpnCqRJVeyF_77qg9oF2UWFw5nZrhnxYoQQUpM6uqiuEzpiPGas6peFacXmKL1JUHKG7RdtAvjm3XWowZtUGfDoOIJYkKhR9b3Tg2DmmzwX_rJGg9L5sc5fgZq3BjihNLiTQwDbJBCo3Uhk2k2y3Vx3iuX4OYnr4r9w_1--1TuXh-ft82uPNQVKYmQrFpLrTAzwJnUgjCMhSJKY2M4BcyAd3ItO6M1SI07zk3fUSE19JoCuypuv8-OMbzPkKb2GObo88eWCsZlRTklv9ZBOWhztTBFpQebdNsIRimraF1n6-4fK4-BwergobeZ_1n4AE5xbwY</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Zaki, Moushira</creator><creator>Fadel, Fatina I</creator><creator>Toukhy, Safinaz Ebrahim El</creator><creator>Youness, Eman R</creator><creator>Selim, Abeer</creator><creator>Sonbaty, Mohamed El</creator><creator>Bassyouni, Hala T. El</creator><general>New Zealand Institute of Medical Laboratory Science</general><scope>3V.</scope><scope>7RV</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AYAGU</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>KB0</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20221101</creationdate><title>Netrin-1 and Cyclophilin A : biomarkers of inflammation and kidney injury in Alport syndrome: a pilot study</title><author>Zaki, Moushira ; Fadel, Fatina I ; Toukhy, Safinaz Ebrahim El ; Youness, Eman R ; Selim, Abeer ; Sonbaty, Mohamed El ; Bassyouni, Hala T. 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El</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Netrin-1 and Cyclophilin A : biomarkers of inflammation and kidney injury in Alport syndrome: a pilot study</atitle><jtitle>New Zealand journal of medical laboratory science</jtitle><date>2022-11-01</date><risdate>2022</risdate><volume>76</volume><issue>3</issue><spage>50</spage><epage>52</epage><pages>50-52</pages><issn>1171-0195</issn><abstract>Background: Netrin-1 and Cyclophilin A (CypA) participate in the pathological processes of inflammation, oxidative stress and apoptosis. Our objective was to determine the level of serum Netrin-1 & Cyclophilin A (CypA) in Alport syndrome. Materials and Methods: The study included 10 Alport syndrome patients, their age ranged from 5-13 years (8.50[+ or - ]2.87) (mean age [+ or -]SD), they were 7 females and 3 males (ratio of 1:0.43) and 10 age and sex matched healthy children. Serum Netrin-1 and Cyclophilin A (CypA) were measured using ELISA kits. Results: All patients presented with haematuria, while 3 cases had mild proteinuria. The renal pathology revealed features like thin basement membrane disease. Sensorineural hearing loss was present in 8 patients and no patients had retinitis pigmentosa. The serum levels of Netrin-1 were 160.47ng/mL [+ or -] 12.833 for controls and 141.91ng/mL [+ or -]16.953 for patients (p < 0.01), for CypA was 7.55ng/mL [+ or -]0.74 in patients compared to 6.27ng/mL [+ or -]0.37 in controls (p<0.001). Conclusion: To the best of our knowledge, this is the first research to investigate the levels of Netrin-1 and Cyclophilin A in Alport syndrome patients. Keywords: Alport syndrome, Cyclophilin A (CypA), Netrin-1, inflammation. N Z J Med Lab Sci 2022; 76(3): 136-138</abstract><cop>Auckland</cop><pub>New Zealand Institute of Medical Laboratory Science</pub><tpages>3</tpages></addata></record> |
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| subjects | Age Apoptosis Biomarkers Hearing loss Hematuria Inflammation Kidney diseases Medical research Medicine, Experimental Mutation Oxidative stress Pathology Pediatrics Research centers |
| title | Netrin-1 and Cyclophilin A : biomarkers of inflammation and kidney injury in Alport syndrome: a pilot study |
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