Regioselective α-addition of vinylogous α-ketoester enolate in organocatalytic asymmetric Michael reactions: enantioselective synthesis of Rauhut-Currier type products

Catalytic asymmetric α-regioselective Michael additions of vinylogous α-ketoester enolate are described herein. With 0.1-1.0 mol% loadings of a chiral bifunctional organocatalyst, the addition of a deconjugated α-keto ester to a series of nitroolefins, including the challenging β-alkylnitroalkenes,...

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Veröffentlicht in:	RSC advances 2022-11, Vol.12 (49), p.3256-326
Hauptverfasser:	Weng, Zhibing, Zhou, Ying, Yue, Xin, Jiang, Feng, Guo, Wengang
Format:	Artikel
Sprache:	eng
Schlagworte:	Asymmetry Chemical synthesis Chemistry Enantiomers Isomerization Regioselectivity
Online-Zugang:	Volltext
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