Phytocannabinoids regulate inflammation in IL‐1β‐stimulated human gingival fibroblasts

Objectives Billions of individuals worldwide suffer from periodontal disease, an inflammatory disease that results in hard‐tissue and soft‐tissue destruction. A viable therapeutic option to treat periodontal disease may be via cannabinoids that exert immunomodulatory effects, and the endocannabinoid...

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Veröffentlicht in:	Journal of periodontal research 2022-12, Vol.57 (6), p.1127-1138
Hauptverfasser:	Abidi, Ammaar H., Abhyankar, Vrushali, Alghamdi, Sahar S., Tipton, David A., Dabbous, Mustafa
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - pharmacology Cannabidiol Cannabinoid CB1 receptors Cannabinoid CB2 receptors Cannabinoids Cannabinoids - pharmacology Cannabis CB1 receptor CB2 receptor Cell viability Cells, Cultured Cholecystokinin Cytokines Cytokines - metabolism Cytotoxicity Dinoprostone - metabolism Endocannabinoid system Endocannabinoids - pharmacology Fibroblasts Gingiva Gingiva - metabolism Gum disease Humans Immunomodulation Inflammation - metabolism Inflammatory diseases Interleukin 6 Interleukin-10 - metabolism Interleukin-13 - metabolism Interleukin-13 - pharmacology Interleukin-1beta - pharmacology Interleukin-2 - metabolism Interleukin-2 - pharmacology Interleukin-4 Interleukin-6 - metabolism Interleukin-8 - metabolism PCB periodontal disease Periodontal diseases Periodontal Diseases - metabolism periodontitis Polychlorinated biphenyls Prostaglandin E Prostaglandin E2 Receptors, Cannabinoid - metabolism Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism
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