Reply to Correspondence on “Synergy and Antagonism between Allosteric and Active‐Site Inhibitors of Abl Tyrosine Kinase”

Manley and co‐workers provide data demonstrating that, at super‐pharmacological concentrations (300 μM), a ternary complex between Abl, asciminib, and ATP‐competitive inhibitors is possible. The work in our manuscript concerns the interplay of asciminib (and GNF‐2) with ATP‐competitive inhibitors at...

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Veröffentlicht in:	Angewandte Chemie 2022-11, Vol.134 (46), p.n/a
Hauptverfasser:	Johnson, Taylor K., Bochar, Daniel A., Vandecan, Nathalie M., Furtado, Jessica, Agius, Michael P., Phadke, Sameer, Soellner, Matthew B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric properties Antagonism Asciminib ATP Chemistry Conformation Inhibitors Kinase Kinases Pharmacology Protein-tyrosine kinase Selectivity Tyrosine Workers
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