Transcription factor Nrf2 binds to circRNAPIBF1 to regulate SOD2 in lung adenocarcinoma progression
Emerging evidence indicates that circular RNAs (circRNAs) play important roles in disease development, especially in cancers. Analysis of circRNA expression microarrays from the Gene Expression Omnibus database revealed that circPIBF1 was highly upregulated in lung adenocarcinoma (LUAD). The main ai...
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| Veröffentlicht in: | Molecular carcinogenesis 2022-12, Vol.61 (12), p.1161-1176 |
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| container_title | Molecular carcinogenesis |
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| creator | Zhang, Zuxiong Chen, Qianshun Huang, Chen Rao, Dingyu Sang, Chengpeng Zhu, Shenyu Gu, Liang Xie, Chunfa Tang, Zhixian Xu, Xunyu |
| description | Emerging evidence indicates that circular RNAs (circRNAs) play important roles in disease development, especially in cancers. Analysis of circRNA expression microarrays from the Gene Expression Omnibus database revealed that circPIBF1 was highly upregulated in lung adenocarcinoma (LUAD). The main aim of this study was to probe the function of circPIBF1 in pyroptosis of LUAD cells and the signal transduction pathways involved. CircPIBF1 was significantly overexpressed in LUAD and was related to the dismal prognosis of patients with LUAD. CircPIBF1 could bind to nuclear factor erythroid 2‐related factor 2 (Nrf2), which further promoted the expression of superoxide dismutase 2 (SOD2). In addition, Nrf2 was also observed to recruit histone acetyltransferase E1A binding protein p300 (EP300) to enhance H3K27ac modification of SOD2, thus modulating the Nrf2‐Keap1 signaling pathway. Moreover, we found that knockdown of circPIBF1 significantly suppressed the expression of SOD2 in cells and LUAD cell growth, while enhanced the expression of pyroptosis‐related factors, which were further reversed by overexpression of SOD2 or EP300. Collectively, our findings suggest a direct involvement of circPIBF1 in pyroptosis‐related LUAD carcinogenesis and implicate a role of Nrf2/EP300/SOD2 signaling in this process. |
| doi_str_mv | 10.1002/mc.23468 |
| format | Article |
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Analysis of circRNA expression microarrays from the Gene Expression Omnibus database revealed that circPIBF1 was highly upregulated in lung adenocarcinoma (LUAD). The main aim of this study was to probe the function of circPIBF1 in pyroptosis of LUAD cells and the signal transduction pathways involved. CircPIBF1 was significantly overexpressed in LUAD and was related to the dismal prognosis of patients with LUAD. CircPIBF1 could bind to nuclear factor erythroid 2‐related factor 2 (Nrf2), which further promoted the expression of superoxide dismutase 2 (SOD2). In addition, Nrf2 was also observed to recruit histone acetyltransferase E1A binding protein p300 (EP300) to enhance H3K27ac modification of SOD2, thus modulating the Nrf2‐Keap1 signaling pathway. Moreover, we found that knockdown of circPIBF1 significantly suppressed the expression of SOD2 in cells and LUAD cell growth, while enhanced the expression of pyroptosis‐related factors, which were further reversed by overexpression of SOD2 or EP300. Collectively, our findings suggest a direct involvement of circPIBF1 in pyroptosis‐related LUAD carcinogenesis and implicate a role of Nrf2/EP300/SOD2 signaling in this process.</description><identifier>ISSN: 0899-1987</identifier><identifier>EISSN: 1098-2744</identifier><identifier>DOI: 10.1002/mc.23468</identifier><identifier>PMID: 36193777</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adenocarcinoma ; Adenocarcinoma - pathology ; Adenocarcinoma of Lung - genetics ; Adenocarcinoma of Lung - pathology ; Cancer ; Carcinogenesis ; Cell Proliferation - genetics ; CircRNA_PIBF1 ; DNA microarrays ; Gene expression ; Gene Expression Regulation, Neoplastic ; Histone acetyltransferase ; Humans ; Kelch-Like ECH-Associated Protein 1 - metabolism ; lung adenocarcinoma ; Lung cancer ; Lung Neoplasms - pathology ; NF-E2-Related Factor 2 - genetics ; NF-E2-Related Factor 2 - metabolism ; Nrf2 ; Pyroptosis ; RNA, Circular - genetics ; Signal transduction ; SOD2 ; Superoxide dismutase</subject><ispartof>Molecular carcinogenesis, 2022-12, Vol.61 (12), p.1161-1176</ispartof><rights>2022 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3498-fb08bea3a5d29af9bdff29e9d5b9cc8416964540aeb49854003129c84eba0c863</citedby><cites>FETCH-LOGICAL-c3498-fb08bea3a5d29af9bdff29e9d5b9cc8416964540aeb49854003129c84eba0c863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmc.23468$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmc.23468$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36193777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Zuxiong</creatorcontrib><creatorcontrib>Chen, Qianshun</creatorcontrib><creatorcontrib>Huang, Chen</creatorcontrib><creatorcontrib>Rao, Dingyu</creatorcontrib><creatorcontrib>Sang, Chengpeng</creatorcontrib><creatorcontrib>Zhu, Shenyu</creatorcontrib><creatorcontrib>Gu, Liang</creatorcontrib><creatorcontrib>Xie, Chunfa</creatorcontrib><creatorcontrib>Tang, Zhixian</creatorcontrib><creatorcontrib>Xu, Xunyu</creatorcontrib><title>Transcription factor Nrf2 binds to circRNAPIBF1 to regulate SOD2 in lung adenocarcinoma progression</title><title>Molecular carcinogenesis</title><addtitle>Mol Carcinog</addtitle><description>Emerging evidence indicates that circular RNAs (circRNAs) play important roles in disease development, especially in cancers. Analysis of circRNA expression microarrays from the Gene Expression Omnibus database revealed that circPIBF1 was highly upregulated in lung adenocarcinoma (LUAD). The main aim of this study was to probe the function of circPIBF1 in pyroptosis of LUAD cells and the signal transduction pathways involved. CircPIBF1 was significantly overexpressed in LUAD and was related to the dismal prognosis of patients with LUAD. CircPIBF1 could bind to nuclear factor erythroid 2‐related factor 2 (Nrf2), which further promoted the expression of superoxide dismutase 2 (SOD2). In addition, Nrf2 was also observed to recruit histone acetyltransferase E1A binding protein p300 (EP300) to enhance H3K27ac modification of SOD2, thus modulating the Nrf2‐Keap1 signaling pathway. Moreover, we found that knockdown of circPIBF1 significantly suppressed the expression of SOD2 in cells and LUAD cell growth, while enhanced the expression of pyroptosis‐related factors, which were further reversed by overexpression of SOD2 or EP300. Collectively, our findings suggest a direct involvement of circPIBF1 in pyroptosis‐related LUAD carcinogenesis and implicate a role of Nrf2/EP300/SOD2 signaling in this process.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma of Lung - genetics</subject><subject>Adenocarcinoma of Lung - pathology</subject><subject>Cancer</subject><subject>Carcinogenesis</subject><subject>Cell Proliferation - genetics</subject><subject>CircRNA_PIBF1</subject><subject>DNA microarrays</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Histone acetyltransferase</subject><subject>Humans</subject><subject>Kelch-Like ECH-Associated Protein 1 - metabolism</subject><subject>lung adenocarcinoma</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - pathology</subject><subject>NF-E2-Related Factor 2 - genetics</subject><subject>NF-E2-Related Factor 2 - metabolism</subject><subject>Nrf2</subject><subject>Pyroptosis</subject><subject>RNA, Circular - genetics</subject><subject>Signal transduction</subject><subject>SOD2</subject><subject>Superoxide dismutase</subject><issn>0899-1987</issn><issn>1098-2744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kFtLwzAYhoMobk7BXyABb7zpzKmHXM7pdKCb6LwOSZqOjjadSYvs35vZ6Z1XXz7y5HnDC8AlRmOMELmt9ZhQlmRHYIgRzyKSMnYMhijjPMI8SwfgzPsNQhinMToFA5pgTtM0HQK9ctJ67cptWzYWFlK3jYMLVxCoSpt72DZQl06_LSav87sZ3u_OrLtKtga-L-8JLC2sOruGMje20dLp0ja1hFvXrJ3xPljPwUkhK28uDnMEPmYPq-lT9Lx8nE8nz5GmLHy6UChTRlIZ54TLgqu8KAg3PI8V1zpjOOEJixmSRgU8HBDFhIcLoyTSWUJH4Lr3huzPzvhWbJrO2RApSEoJYzw8CdRNT2nXeO9MIbaurKXbCYzEvk1Ra_HTZkCvDsJO1Sb_A3_rC0DUA19lZXb_isTLtBd-A3sIfMc</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>Zhang, Zuxiong</creator><creator>Chen, Qianshun</creator><creator>Huang, Chen</creator><creator>Rao, Dingyu</creator><creator>Sang, Chengpeng</creator><creator>Zhu, Shenyu</creator><creator>Gu, Liang</creator><creator>Xie, Chunfa</creator><creator>Tang, Zhixian</creator><creator>Xu, Xunyu</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>202212</creationdate><title>Transcription factor Nrf2 binds to circRNAPIBF1 to regulate SOD2 in lung adenocarcinoma progression</title><author>Zhang, Zuxiong ; Chen, Qianshun ; Huang, Chen ; Rao, Dingyu ; Sang, Chengpeng ; Zhu, Shenyu ; Gu, Liang ; Xie, Chunfa ; Tang, Zhixian ; Xu, Xunyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3498-fb08bea3a5d29af9bdff29e9d5b9cc8416964540aeb49854003129c84eba0c863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma of Lung - genetics</topic><topic>Adenocarcinoma of Lung - pathology</topic><topic>Cancer</topic><topic>Carcinogenesis</topic><topic>Cell Proliferation - genetics</topic><topic>CircRNA_PIBF1</topic><topic>DNA microarrays</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Histone acetyltransferase</topic><topic>Humans</topic><topic>Kelch-Like ECH-Associated Protein 1 - metabolism</topic><topic>lung adenocarcinoma</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - pathology</topic><topic>NF-E2-Related Factor 2 - genetics</topic><topic>NF-E2-Related Factor 2 - metabolism</topic><topic>Nrf2</topic><topic>Pyroptosis</topic><topic>RNA, Circular - genetics</topic><topic>Signal transduction</topic><topic>SOD2</topic><topic>Superoxide dismutase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Zuxiong</creatorcontrib><creatorcontrib>Chen, Qianshun</creatorcontrib><creatorcontrib>Huang, Chen</creatorcontrib><creatorcontrib>Rao, Dingyu</creatorcontrib><creatorcontrib>Sang, Chengpeng</creatorcontrib><creatorcontrib>Zhu, Shenyu</creatorcontrib><creatorcontrib>Gu, Liang</creatorcontrib><creatorcontrib>Xie, Chunfa</creatorcontrib><creatorcontrib>Tang, Zhixian</creatorcontrib><creatorcontrib>Xu, Xunyu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Molecular carcinogenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Zuxiong</au><au>Chen, Qianshun</au><au>Huang, Chen</au><au>Rao, Dingyu</au><au>Sang, Chengpeng</au><au>Zhu, Shenyu</au><au>Gu, Liang</au><au>Xie, Chunfa</au><au>Tang, Zhixian</au><au>Xu, Xunyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcription factor Nrf2 binds to circRNAPIBF1 to regulate SOD2 in lung adenocarcinoma progression</atitle><jtitle>Molecular carcinogenesis</jtitle><addtitle>Mol Carcinog</addtitle><date>2022-12</date><risdate>2022</risdate><volume>61</volume><issue>12</issue><spage>1161</spage><epage>1176</epage><pages>1161-1176</pages><issn>0899-1987</issn><eissn>1098-2744</eissn><abstract>Emerging evidence indicates that circular RNAs (circRNAs) play important roles in disease development, especially in cancers. Analysis of circRNA expression microarrays from the Gene Expression Omnibus database revealed that circPIBF1 was highly upregulated in lung adenocarcinoma (LUAD). The main aim of this study was to probe the function of circPIBF1 in pyroptosis of LUAD cells and the signal transduction pathways involved. CircPIBF1 was significantly overexpressed in LUAD and was related to the dismal prognosis of patients with LUAD. CircPIBF1 could bind to nuclear factor erythroid 2‐related factor 2 (Nrf2), which further promoted the expression of superoxide dismutase 2 (SOD2). In addition, Nrf2 was also observed to recruit histone acetyltransferase E1A binding protein p300 (EP300) to enhance H3K27ac modification of SOD2, thus modulating the Nrf2‐Keap1 signaling pathway. Moreover, we found that knockdown of circPIBF1 significantly suppressed the expression of SOD2 in cells and LUAD cell growth, while enhanced the expression of pyroptosis‐related factors, which were further reversed by overexpression of SOD2 or EP300. Collectively, our findings suggest a direct involvement of circPIBF1 in pyroptosis‐related LUAD carcinogenesis and implicate a role of Nrf2/EP300/SOD2 signaling in this process.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36193777</pmid><doi>10.1002/mc.23468</doi><tpages>16</tpages></addata></record> |
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| ispartof | Molecular carcinogenesis, 2022-12, Vol.61 (12), p.1161-1176 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adenocarcinoma Adenocarcinoma - pathology Adenocarcinoma of Lung - genetics Adenocarcinoma of Lung - pathology Cancer Carcinogenesis Cell Proliferation - genetics CircRNA_PIBF1 DNA microarrays Gene expression Gene Expression Regulation, Neoplastic Histone acetyltransferase Humans Kelch-Like ECH-Associated Protein 1 - metabolism lung adenocarcinoma Lung cancer Lung Neoplasms - pathology NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nrf2 Pyroptosis RNA, Circular - genetics Signal transduction SOD2 Superoxide dismutase |
| title | Transcription factor Nrf2 binds to circRNAPIBF1 to regulate SOD2 in lung adenocarcinoma progression |
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