Dual-Tracer PET/CT Protocol with [ 18 F]-FDG and [ 68 Ga]Ga-FAPI-46 for Cancer Imaging: A Proof of Concept
Imaging studies with PET tracers acting as fibroblast activation protein inhibitors (FAPIs) show promising results that could usefully complement [ F]-FDG in cancer imaging. All patients received [ F]-FDG PET/CT and dual-tracer PET/CT after an additional injection of [ Ga]Ga-FAPI-46 after the [ F]-F...
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| Veröffentlicht in: | Journal of Nuclear Medicine 2022-11, Vol.63 (11), p.1683 |
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| container_issue | 11 |
| container_start_page | 1683 |
| container_title | Journal of Nuclear Medicine |
| container_volume | 63 |
| creator | Roth, Katrin S Voltin, Conrad-Amadeus van Heek, Lutz Wegen, Simone Schomäcker, Klaus Fischer, Thomas Marnitz, Simone Drzezga, Alexander Kobe, Carsten |
| description | Imaging studies with PET tracers acting as fibroblast activation protein inhibitors (FAPIs) show promising results that could usefully complement [
F]-FDG in cancer imaging.
All patients received [
F]-FDG PET/CT and dual-tracer PET/CT after an additional injection of [
Ga]Ga-FAPI-46 after the [
F]-FDG PET/CT. Two readers visually compared detection rate and analyzed target-to-background ratios for tumor and metastatic tissue in single- and dual-tracer PET/CT.
Detection rate in dual-tracer PET/CT was visually as good as that in single-tracer PET/CT in 4 patients and superior in 2 patients, whereas target-to-background ratios were significantly higher in dual-tracer PET/CT.
Dual-tracer [
F]-FDG/[
Ga]Ga-FAPI-46 PET/CT within a single session is feasible and has potential. The dual-tracer approach may have superior sensitivity to [
F]-FDG PET/CT alone without compromising individual assessment of either scan. |
| doi_str_mv | 10.2967/jnumed.122.263835 |
| format | Article |
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F]-FDG in cancer imaging.
All patients received [
F]-FDG PET/CT and dual-tracer PET/CT after an additional injection of [
Ga]Ga-FAPI-46 after the [
F]-FDG PET/CT. Two readers visually compared detection rate and analyzed target-to-background ratios for tumor and metastatic tissue in single- and dual-tracer PET/CT.
Detection rate in dual-tracer PET/CT was visually as good as that in single-tracer PET/CT in 4 patients and superior in 2 patients, whereas target-to-background ratios were significantly higher in dual-tracer PET/CT.
Dual-tracer [
F]-FDG/[
Ga]Ga-FAPI-46 PET/CT within a single session is feasible and has potential. The dual-tracer approach may have superior sensitivity to [
F]-FDG PET/CT alone without compromising individual assessment of either scan.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>EISSN: 2159-662X</identifier><identifier>DOI: 10.2967/jnumed.122.263835</identifier><identifier>PMID: 35422446</identifier><language>eng</language><publisher>United States: Society of Nuclear Medicine</publisher><subject>Cancer ; Complement activation ; Computed tomography ; Fibroblast activation protein ; Fluorine isotopes ; Fluorodeoxyglucose F18 ; Gallium Radioisotopes ; Humans ; Medical imaging ; Metastases ; Neoplasms - metabolism ; Positron emission ; Positron emission tomography ; Positron Emission Tomography Computed Tomography - methods ; Quinolines ; Target detection ; Tumors</subject><ispartof>Journal of Nuclear Medicine, 2022-11, Vol.63 (11), p.1683</ispartof><rights>2022 by the Society of Nuclear Medicine and Molecular Imaging.</rights><rights>Copyright Society of Nuclear Medicine Nov 1, 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-ab00d962dd4e714a66fce9d229ced736d466b15f0f575e9d2044f2353ea84b293</citedby><orcidid>0000-0002-5437-3959</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35422446$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roth, Katrin S</creatorcontrib><creatorcontrib>Voltin, Conrad-Amadeus</creatorcontrib><creatorcontrib>van Heek, Lutz</creatorcontrib><creatorcontrib>Wegen, Simone</creatorcontrib><creatorcontrib>Schomäcker, Klaus</creatorcontrib><creatorcontrib>Fischer, Thomas</creatorcontrib><creatorcontrib>Marnitz, Simone</creatorcontrib><creatorcontrib>Drzezga, Alexander</creatorcontrib><creatorcontrib>Kobe, Carsten</creatorcontrib><title>Dual-Tracer PET/CT Protocol with [ 18 F]-FDG and [ 68 Ga]Ga-FAPI-46 for Cancer Imaging: A Proof of Concept</title><title>Journal of Nuclear Medicine</title><addtitle>J Nucl Med</addtitle><description>Imaging studies with PET tracers acting as fibroblast activation protein inhibitors (FAPIs) show promising results that could usefully complement [
F]-FDG in cancer imaging.
All patients received [
F]-FDG PET/CT and dual-tracer PET/CT after an additional injection of [
Ga]Ga-FAPI-46 after the [
F]-FDG PET/CT. Two readers visually compared detection rate and analyzed target-to-background ratios for tumor and metastatic tissue in single- and dual-tracer PET/CT.
Detection rate in dual-tracer PET/CT was visually as good as that in single-tracer PET/CT in 4 patients and superior in 2 patients, whereas target-to-background ratios were significantly higher in dual-tracer PET/CT.
Dual-tracer [
F]-FDG/[
Ga]Ga-FAPI-46 PET/CT within a single session is feasible and has potential. The dual-tracer approach may have superior sensitivity to [
F]-FDG PET/CT alone without compromising individual assessment of either scan.</description><subject>Cancer</subject><subject>Complement activation</subject><subject>Computed tomography</subject><subject>Fibroblast activation protein</subject><subject>Fluorine isotopes</subject><subject>Fluorodeoxyglucose F18</subject><subject>Gallium Radioisotopes</subject><subject>Humans</subject><subject>Medical imaging</subject><subject>Metastases</subject><subject>Neoplasms - metabolism</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Positron Emission Tomography Computed Tomography - methods</subject><subject>Quinolines</subject><subject>Target detection</subject><subject>Tumors</subject><issn>0161-5505</issn><issn>1535-5667</issn><issn>2159-662X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kF1rwjAUhsPYmM7tB-xmBHYdzXfT3Um1nSDMi-5qSEjb1CnauLRl7N-vpQoHDof348ADwDPBUxrKYHao2pMtpoTSKZVMMXEDxkQwgYSUwS0YYyIJEgKLEXio6wPGWCql7sGICU4p53IMDovWHFHqTW493CzTWZTCjXeNy90R_u6bb_gFiYLxFsWLBJqq6G6pYGK2iUHxfLNCXMLSeRiZqq9YncxuX-3e4LyvcSXsJnKddG4ewV1pjrV9uuwJ-IyXafSO1h_JKpqvUc4C2iCTYVyEkhYFtwHhRsoyt2FBaZjbImCy4FJmRJS4FIHoBcx5SZlg1iie0ZBNwOvQe_bup7V1ow-u9VX3UtOAEUWYJKpzkcGVe1fX3pb67Pcn4_80wbqnqwe6uqOrB7pd5uXS3Ga9dE1ccbJ_lMJxwA</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Roth, Katrin S</creator><creator>Voltin, Conrad-Amadeus</creator><creator>van Heek, Lutz</creator><creator>Wegen, Simone</creator><creator>Schomäcker, Klaus</creator><creator>Fischer, Thomas</creator><creator>Marnitz, Simone</creator><creator>Drzezga, Alexander</creator><creator>Kobe, Carsten</creator><general>Society of Nuclear Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>4T-</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0002-5437-3959</orcidid></search><sort><creationdate>20221101</creationdate><title>Dual-Tracer PET/CT Protocol with [ 18 F]-FDG and [ 68 Ga]Ga-FAPI-46 for Cancer Imaging: A Proof of Concept</title><author>Roth, Katrin S ; Voltin, Conrad-Amadeus ; van Heek, Lutz ; Wegen, Simone ; Schomäcker, Klaus ; Fischer, Thomas ; Marnitz, Simone ; Drzezga, Alexander ; Kobe, Carsten</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-ab00d962dd4e714a66fce9d229ced736d466b15f0f575e9d2044f2353ea84b293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cancer</topic><topic>Complement activation</topic><topic>Computed tomography</topic><topic>Fibroblast activation protein</topic><topic>Fluorine isotopes</topic><topic>Fluorodeoxyglucose F18</topic><topic>Gallium Radioisotopes</topic><topic>Humans</topic><topic>Medical imaging</topic><topic>Metastases</topic><topic>Neoplasms - metabolism</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Positron Emission Tomography Computed Tomography - methods</topic><topic>Quinolines</topic><topic>Target detection</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roth, Katrin S</creatorcontrib><creatorcontrib>Voltin, Conrad-Amadeus</creatorcontrib><creatorcontrib>van Heek, Lutz</creatorcontrib><creatorcontrib>Wegen, Simone</creatorcontrib><creatorcontrib>Schomäcker, Klaus</creatorcontrib><creatorcontrib>Fischer, Thomas</creatorcontrib><creatorcontrib>Marnitz, Simone</creatorcontrib><creatorcontrib>Drzezga, Alexander</creatorcontrib><creatorcontrib>Kobe, Carsten</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Docstoc</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of Nuclear Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roth, Katrin S</au><au>Voltin, Conrad-Amadeus</au><au>van Heek, Lutz</au><au>Wegen, Simone</au><au>Schomäcker, Klaus</au><au>Fischer, Thomas</au><au>Marnitz, Simone</au><au>Drzezga, Alexander</au><au>Kobe, Carsten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dual-Tracer PET/CT Protocol with [ 18 F]-FDG and [ 68 Ga]Ga-FAPI-46 for Cancer Imaging: A Proof of Concept</atitle><jtitle>Journal of Nuclear Medicine</jtitle><addtitle>J Nucl Med</addtitle><date>2022-11-01</date><risdate>2022</risdate><volume>63</volume><issue>11</issue><spage>1683</spage><pages>1683-</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><eissn>2159-662X</eissn><abstract>Imaging studies with PET tracers acting as fibroblast activation protein inhibitors (FAPIs) show promising results that could usefully complement [
F]-FDG in cancer imaging.
All patients received [
F]-FDG PET/CT and dual-tracer PET/CT after an additional injection of [
Ga]Ga-FAPI-46 after the [
F]-FDG PET/CT. Two readers visually compared detection rate and analyzed target-to-background ratios for tumor and metastatic tissue in single- and dual-tracer PET/CT.
Detection rate in dual-tracer PET/CT was visually as good as that in single-tracer PET/CT in 4 patients and superior in 2 patients, whereas target-to-background ratios were significantly higher in dual-tracer PET/CT.
Dual-tracer [
F]-FDG/[
Ga]Ga-FAPI-46 PET/CT within a single session is feasible and has potential. The dual-tracer approach may have superior sensitivity to [
F]-FDG PET/CT alone without compromising individual assessment of either scan.</abstract><cop>United States</cop><pub>Society of Nuclear Medicine</pub><pmid>35422446</pmid><doi>10.2967/jnumed.122.263835</doi><orcidid>https://orcid.org/0000-0002-5437-3959</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Nuclear Medicine, 2022-11, Vol.63 (11), p.1683 |
| issn | 0161-5505 1535-5667 2159-662X |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Cancer Complement activation Computed tomography Fibroblast activation protein Fluorine isotopes Fluorodeoxyglucose F18 Gallium Radioisotopes Humans Medical imaging Metastases Neoplasms - metabolism Positron emission Positron emission tomography Positron Emission Tomography Computed Tomography - methods Quinolines Target detection Tumors |
| title | Dual-Tracer PET/CT Protocol with [ 18 F]-FDG and [ 68 Ga]Ga-FAPI-46 for Cancer Imaging: A Proof of Concept |
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