Taurine mitigates the development of pulmonary inflammation, oxidative stress, and histopathological alterations in a rat model of bile duct ligation
Lung injury is a significant complication associated with cholestasis/cirrhosis. This problem significantly increases the risk of cirrhosis-related morbidity and mortality. Hence, finding effective therapeutic options in this field has significant clinical value. Severe inflammation and oxidative st...
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| creator | Ommati, Mohammad Mehdi Mobasheri, Ali Ma, Yanqin Xu, Dongmei Tang, Zhongwei Manthari, Ram Kumar Abdoli, Narges Azarpira, Negar Lu, Yu Sadeghian, Issa Mousavifaraz, Abolghasem Nadgaran, Ali Nikoozadeh, Ahmad Mazloomi, Sahra Mehrabani, Pooria Sayar Rezaei, Mohammad Xin, Hu Mingyu, Yang Niknahad, Hossein Heidari, Reza |
| description | Lung injury is a significant complication associated with cholestasis/cirrhosis. This problem significantly increases the risk of cirrhosis-related morbidity and mortality. Hence, finding effective therapeutic options in this field has significant clinical value. Severe inflammation and oxidative stress are involved in the mechanism of cirrhosis-induced lung injury. Taurine (TAU) is an abundant amino acid with substantial anti-inflammatory and antioxidative properties. The current study was designed to evaluate the role of TAU in cholestasis-related lung injury. For this purpose, bile duct ligated (BDL) rats were treated with TAU (0.5 and 1% w: v in drinking water). Significant increases in the broncho-alveolar lavage fluid (BALF) level of inflammatory cells (lymphocytes, neutrophils, basophils, monocytes, and eosinophils), increased IgG, and TNF-α were detected in the BDL animals (14 and 28 days after the BDL surgery). Alveolar congestion, hemorrhage, and fibrosis were the dominant pulmonary histopathological changes in the BDL group. Significant increases in the pulmonary tissue biomarkers of oxidative stress, including reactive oxygen species formation, lipid peroxidation, increased oxidized glutathione levels, and decreased reduced glutathione, were also detected in the BDL rats. Moreover, significant myeloperoxidase activity and nitric oxide levels were seen in the lung of BDL rats. It was found that TAU significantly blunted inflammation, alleviated oxidative stress, and mitigated lung histopathological changes in BDL animals. These data suggest TAU as a potential protective agent against cholestasis/cirrhosis-related lung injury. |
| doi_str_mv | 10.1007/s00210-022-02291-7 |
| format | Article |
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This problem significantly increases the risk of cirrhosis-related morbidity and mortality. Hence, finding effective therapeutic options in this field has significant clinical value. Severe inflammation and oxidative stress are involved in the mechanism of cirrhosis-induced lung injury. Taurine (TAU) is an abundant amino acid with substantial anti-inflammatory and antioxidative properties. The current study was designed to evaluate the role of TAU in cholestasis-related lung injury. For this purpose, bile duct ligated (BDL) rats were treated with TAU (0.5 and 1% w: v in drinking water). Significant increases in the broncho-alveolar lavage fluid (BALF) level of inflammatory cells (lymphocytes, neutrophils, basophils, monocytes, and eosinophils), increased IgG, and TNF-α were detected in the BDL animals (14 and 28 days after the BDL surgery). Alveolar congestion, hemorrhage, and fibrosis were the dominant pulmonary histopathological changes in the BDL group. Significant increases in the pulmonary tissue biomarkers of oxidative stress, including reactive oxygen species formation, lipid peroxidation, increased oxidized glutathione levels, and decreased reduced glutathione, were also detected in the BDL rats. Moreover, significant myeloperoxidase activity and nitric oxide levels were seen in the lung of BDL rats. It was found that TAU significantly blunted inflammation, alleviated oxidative stress, and mitigated lung histopathological changes in BDL animals. These data suggest TAU as a potential protective agent against cholestasis/cirrhosis-related lung injury.</description><identifier>ISSN: 0028-1298</identifier><identifier>EISSN: 1432-1912</identifier><identifier>DOI: 10.1007/s00210-022-02291-7</identifier><identifier>PMID: 36097067</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Alveoli ; Amino acids ; Animals ; Antioxidants - therapeutic use ; Bile ducts ; Bile Ducts - surgery ; Biomedical and Life Sciences ; Biomedicine ; Cholestasis ; Cholestasis - drug therapy ; Cholestasis - metabolism ; Cirrhosis ; Drinking water ; Fibrosis ; Gallbladder diseases ; Glutathione ; Hemorrhage ; Immunoglobulin G ; Inflammation ; Inflammation - drug therapy ; Inflammation - metabolism ; Leukocytes (basophilic) ; Leukocytes (eosinophilic) ; Leukocytes (neutrophilic) ; Ligation - adverse effects ; Lipid peroxidation ; Liver ; Liver cirrhosis ; Liver Cirrhosis - pathology ; Lung diseases ; Lung Injury - drug therapy ; Lung Injury - etiology ; Lung Injury - prevention & control ; Lymphocytes ; Monocytes ; Morbidity ; Neurosciences ; Nitric oxide ; Oxidation ; Oxidative Stress ; Peroxidase ; Pharmacology/Toxicology ; Pneumonia - pathology ; Rats ; Reactive oxygen species ; Taurine ; Taurine - pharmacology ; Taurine - therapeutic use ; Tumor necrosis factor-α</subject><ispartof>Naunyn-Schmiedeberg's archives of pharmacology, 2022-12, Vol.395 (12), p.1557-1572</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. 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The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-e5d739a2a8317b7a81e4e10b6c1b8660390fa287c2e5d7c71728dc82b06919e3</citedby><cites>FETCH-LOGICAL-c375t-e5d739a2a8317b7a81e4e10b6c1b8660390fa287c2e5d7c71728dc82b06919e3</cites><orcidid>0000-0002-7038-9838</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00210-022-02291-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00210-022-02291-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36097067$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ommati, Mohammad Mehdi</creatorcontrib><creatorcontrib>Mobasheri, Ali</creatorcontrib><creatorcontrib>Ma, Yanqin</creatorcontrib><creatorcontrib>Xu, Dongmei</creatorcontrib><creatorcontrib>Tang, Zhongwei</creatorcontrib><creatorcontrib>Manthari, Ram Kumar</creatorcontrib><creatorcontrib>Abdoli, Narges</creatorcontrib><creatorcontrib>Azarpira, Negar</creatorcontrib><creatorcontrib>Lu, Yu</creatorcontrib><creatorcontrib>Sadeghian, Issa</creatorcontrib><creatorcontrib>Mousavifaraz, Abolghasem</creatorcontrib><creatorcontrib>Nadgaran, Ali</creatorcontrib><creatorcontrib>Nikoozadeh, Ahmad</creatorcontrib><creatorcontrib>Mazloomi, Sahra</creatorcontrib><creatorcontrib>Mehrabani, Pooria Sayar</creatorcontrib><creatorcontrib>Rezaei, Mohammad</creatorcontrib><creatorcontrib>Xin, Hu</creatorcontrib><creatorcontrib>Mingyu, Yang</creatorcontrib><creatorcontrib>Niknahad, Hossein</creatorcontrib><creatorcontrib>Heidari, Reza</creatorcontrib><title>Taurine mitigates the development of pulmonary inflammation, oxidative stress, and histopathological alterations in a rat model of bile duct ligation</title><title>Naunyn-Schmiedeberg's archives of pharmacology</title><addtitle>Naunyn-Schmiedeberg's Arch Pharmacol</addtitle><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><description>Lung injury is a significant complication associated with cholestasis/cirrhosis. This problem significantly increases the risk of cirrhosis-related morbidity and mortality. Hence, finding effective therapeutic options in this field has significant clinical value. Severe inflammation and oxidative stress are involved in the mechanism of cirrhosis-induced lung injury. Taurine (TAU) is an abundant amino acid with substantial anti-inflammatory and antioxidative properties. The current study was designed to evaluate the role of TAU in cholestasis-related lung injury. For this purpose, bile duct ligated (BDL) rats were treated with TAU (0.5 and 1% w: v in drinking water). Significant increases in the broncho-alveolar lavage fluid (BALF) level of inflammatory cells (lymphocytes, neutrophils, basophils, monocytes, and eosinophils), increased IgG, and TNF-α were detected in the BDL animals (14 and 28 days after the BDL surgery). Alveolar congestion, hemorrhage, and fibrosis were the dominant pulmonary histopathological changes in the BDL group. 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These data suggest TAU as a potential protective agent against cholestasis/cirrhosis-related lung injury.</description><subject>Alveoli</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Antioxidants - therapeutic use</subject><subject>Bile ducts</subject><subject>Bile Ducts - surgery</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cholestasis</subject><subject>Cholestasis - drug therapy</subject><subject>Cholestasis - metabolism</subject><subject>Cirrhosis</subject><subject>Drinking water</subject><subject>Fibrosis</subject><subject>Gallbladder diseases</subject><subject>Glutathione</subject><subject>Hemorrhage</subject><subject>Immunoglobulin G</subject><subject>Inflammation</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - metabolism</subject><subject>Leukocytes (basophilic)</subject><subject>Leukocytes (eosinophilic)</subject><subject>Leukocytes (neutrophilic)</subject><subject>Ligation - adverse effects</subject><subject>Lipid peroxidation</subject><subject>Liver</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - pathology</subject><subject>Lung diseases</subject><subject>Lung Injury - drug therapy</subject><subject>Lung Injury - etiology</subject><subject>Lung Injury - prevention & control</subject><subject>Lymphocytes</subject><subject>Monocytes</subject><subject>Morbidity</subject><subject>Neurosciences</subject><subject>Nitric oxide</subject><subject>Oxidation</subject><subject>Oxidative Stress</subject><subject>Peroxidase</subject><subject>Pharmacology/Toxicology</subject><subject>Pneumonia - pathology</subject><subject>Rats</subject><subject>Reactive oxygen species</subject><subject>Taurine</subject><subject>Taurine - pharmacology</subject><subject>Taurine - therapeutic use</subject><subject>Tumor necrosis factor-α</subject><issn>0028-1298</issn><issn>1432-1912</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kcFu1DAQhi1URJfCC3BAlnptYMbuxvGxqlpAqsRl75aTTHZdOXFqOxV9EN4Xp1vojYNlj-b7_7HmZ-wTwhcEUF8TgECoQIj1aKzUG7bBSykq1ChO2Kb0mwqFbk7Z-5TuAaDG7fYdO5U1aAW12rDfO7tENxEfXXZ7mynxfCDe0yP5MI80ZR4GPi9-DJONT9xNg7fjaLML0wUPv1xfno_EU46U0gW3U88PLuUw23wIPuxdZz23PlN81qTiwC0vBR9DT351b50vE5cuc79-oVAf2NvB-kQfX-4ztru92V1_r-5-fvtxfXVXdVJtc0XbXklthW0kqlbZBumSENq6w7apa5AaBisa1YmV7BQq0fRdI1qoNWqSZ-z8aDvH8LBQyuY-LHEqE41QEotSSF0ocaS6GFKKNJg5urEswyCYNQhzDMKUEMxzEEYV0ecX66Udqf8n-bv5AsgjkEpr2lN8nf0f2z9Zy5Yt</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Ommati, Mohammad Mehdi</creator><creator>Mobasheri, Ali</creator><creator>Ma, Yanqin</creator><creator>Xu, Dongmei</creator><creator>Tang, Zhongwei</creator><creator>Manthari, Ram Kumar</creator><creator>Abdoli, Narges</creator><creator>Azarpira, Negar</creator><creator>Lu, Yu</creator><creator>Sadeghian, Issa</creator><creator>Mousavifaraz, Abolghasem</creator><creator>Nadgaran, Ali</creator><creator>Nikoozadeh, Ahmad</creator><creator>Mazloomi, Sahra</creator><creator>Mehrabani, Pooria Sayar</creator><creator>Rezaei, Mohammad</creator><creator>Xin, Hu</creator><creator>Mingyu, Yang</creator><creator>Niknahad, Hossein</creator><creator>Heidari, Reza</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0002-7038-9838</orcidid></search><sort><creationdate>20221201</creationdate><title>Taurine mitigates the development of pulmonary inflammation, oxidative stress, and histopathological alterations in a rat model of bile duct ligation</title><author>Ommati, Mohammad Mehdi ; Mobasheri, Ali ; Ma, Yanqin ; Xu, Dongmei ; Tang, Zhongwei ; Manthari, Ram Kumar ; Abdoli, Narges ; Azarpira, Negar ; Lu, Yu ; Sadeghian, Issa ; Mousavifaraz, Abolghasem ; Nadgaran, Ali ; Nikoozadeh, Ahmad ; Mazloomi, Sahra ; Mehrabani, Pooria Sayar ; Rezaei, Mohammad ; Xin, Hu ; Mingyu, Yang ; Niknahad, Hossein ; Heidari, Reza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-e5d739a2a8317b7a81e4e10b6c1b8660390fa287c2e5d7c71728dc82b06919e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alveoli</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Antioxidants - 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Significant increases in the pulmonary tissue biomarkers of oxidative stress, including reactive oxygen species formation, lipid peroxidation, increased oxidized glutathione levels, and decreased reduced glutathione, were also detected in the BDL rats. Moreover, significant myeloperoxidase activity and nitric oxide levels were seen in the lung of BDL rats. It was found that TAU significantly blunted inflammation, alleviated oxidative stress, and mitigated lung histopathological changes in BDL animals. These data suggest TAU as a potential protective agent against cholestasis/cirrhosis-related lung injury.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36097067</pmid><doi>10.1007/s00210-022-02291-7</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-7038-9838</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-1298 |
| ispartof | Naunyn-Schmiedeberg's archives of pharmacology, 2022-12, Vol.395 (12), p.1557-1572 |
| issn | 0028-1298 1432-1912 |
| language | eng |
| recordid | cdi_proquest_journals_2731287239 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Alveoli Amino acids Animals Antioxidants - therapeutic use Bile ducts Bile Ducts - surgery Biomedical and Life Sciences Biomedicine Cholestasis Cholestasis - drug therapy Cholestasis - metabolism Cirrhosis Drinking water Fibrosis Gallbladder diseases Glutathione Hemorrhage Immunoglobulin G Inflammation Inflammation - drug therapy Inflammation - metabolism Leukocytes (basophilic) Leukocytes (eosinophilic) Leukocytes (neutrophilic) Ligation - adverse effects Lipid peroxidation Liver Liver cirrhosis Liver Cirrhosis - pathology Lung diseases Lung Injury - drug therapy Lung Injury - etiology Lung Injury - prevention & control Lymphocytes Monocytes Morbidity Neurosciences Nitric oxide Oxidation Oxidative Stress Peroxidase Pharmacology/Toxicology Pneumonia - pathology Rats Reactive oxygen species Taurine Taurine - pharmacology Taurine - therapeutic use Tumor necrosis factor-α |
| title | Taurine mitigates the development of pulmonary inflammation, oxidative stress, and histopathological alterations in a rat model of bile duct ligation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T02%3A11%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Taurine%20mitigates%20the%20development%20of%20pulmonary%20inflammation,%20oxidative%20stress,%20and%20histopathological%20alterations%20in%20a%20rat%20model%20of%20bile%20duct%20ligation&rft.jtitle=Naunyn-Schmiedeberg's%20archives%20of%20pharmacology&rft.au=Ommati,%20Mohammad%20Mehdi&rft.date=2022-12-01&rft.volume=395&rft.issue=12&rft.spage=1557&rft.epage=1572&rft.pages=1557-1572&rft.issn=0028-1298&rft.eissn=1432-1912&rft_id=info:doi/10.1007/s00210-022-02291-7&rft_dat=%3Cproquest_cross%3E2731287239%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2731287239&rft_id=info:pmid/36097067&rfr_iscdi=true |