Fragment-based design of α-cyanoacrylates and α-cyanoacrylamides targeting Dengue and Zika NS2B/NS3 proteases

Viruses belonging to the Flaviviridae family account for millions of cases of infections worldwide, mainly Dengue (DENV) and Zika (ZIKV) viruses. Both mosquito-borne flaviviruses are transmitted by bites of infected Aedes vectors, which are mainly endemic in tropical and sub-tropical countries. DENV...

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Veröffentlicht in:	New journal of chemistry 2022-10, Vol.46 (42), p.2322-2346
Hauptverfasser:	Vilela, Gabriel Gomes, Silva, Wadja Feitosa dos Santos, Batista, Vitoria de Melo, Silva, Leandro Rocha, Maus, Hannah, Hammerschmidt, Stefan Josef, Costa, Clara Andrezza Crisóstomo Bezerra, Moura, Orlando Francisco da Silva, de Freitas, Johnnatan Duarte, Coelho, Grazielle Lobo, Brandão, Júlia de Andrade, Anderson, Leticia, Bassi, Ênio José, Xavier de Araújo-Júnior, João, Schirmeister, Tanja, Silva-Júnior, Edeildo Ferreira da
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical compounds Cyanoacrylates Dynamic stability Enzymes Pharmacology Replication Viruses Zika virus
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