Significance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinoma
Background The study investigated the expression and the clinicopathological significance of p53, p27, Ki-67, E-cadherin, and HER2 in upper urinary tract urothelial carcinomas (UTUC) from Tunisian patients. We performed a retrospective study of 66 UTUC. Main clinicopathological features were reporte...
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| Veröffentlicht in: | Journal of Egyptian National Cancer Institute 2020-09, Vol.32 (1), p.1-8, Article 36 |
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| creator | Missaoui, Nabiha Bdioui, Ahlem Baccouche, Atika Belkacem, Oussema Hmida, Wissem Mokni, Moncef Hmissa, Sihem |
| description | Background
The study investigated the expression and the clinicopathological significance of p53, p27, Ki-67, E-cadherin, and HER2 in upper urinary tract urothelial carcinomas (UTUC) from Tunisian patients. We performed a retrospective study of 66 UTUC. Main clinicopathological features were reported. The expression of p53, p27, Ki-67, E-cadherin, and HER2 was investigated by immunohistochemistry on whole tissue section.
Results
Expression of p53, Ki-67, p27, E-cadherin, and HERE2 was reported in 36.4%, 69.7%, 90.9%, 100%, and 0% of cases, respectively. p53 expression was associated with stage (
p
= 0.001), positive surgical margin (
p
= 0.005), and shorter recurrence-free survival (RFS; Log Rank test,
p
= 0.026). Ki-67 and p27 expression was associated with stage (
p
< 0.001 and
p
= 0.001, respectively) and grade (
p
< 0.001 and
p
= 0.001, respectively). Using Kaplan-Meier test, the positive surgical margin was associated with shorter RFS compared to free surgical margin (Log Rank test,
p
= 0.031). Moreover, in univariate Cox regression analysis, surgical margin (
p
= 0.041; HR 0.325, 95% CI 0.110–0.956) and p53 expression (
p
= 0.035; HR 0.328, 95% CI 0.116–0.925) were the significant factors associated with RFS.
Conclusions
Together, our findings suggest that positive surgical margin and p53 expression were potential prognostic factors of UTUC since both were associated with shorter RFS in Tunisian patients. |
| doi_str_mv | 10.1186/s43046-020-00047-z |
| format | Article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_proquest_journals_2729536222</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A680085109</galeid><doaj_id>oai_doaj_org_article_14e1c9ec99144d3e902e391b3b6a6444</doaj_id><sourcerecordid>A680085109</sourcerecordid><originalsourceid>FETCH-LOGICAL-c529t-8c38b9be639ce46e5e15f6f5d0cdbe260c0d8e38763a30f102e0b3bf8e50af9c3</originalsourceid><addsrcrecordid>eNp9kV1rFTEQhhdRsFb_gFcBb8-2k8_dXJZytKUFwY_rkM1OTnPYk6zJHtD-etOuWAWRXExmeN-HSd6meUvhjNJenRfBQagWGLQAILr2_llzwmSvWxCgn_9xf9m8KmUPoBR08qSZPoddDD44Gx2S5Mks-YbMrNuQm9CqWrats-Md5hA3xMaRXG0_MYLf54ylhBRJiOQ4z5jJsUps_kGWbN1Su7Tc4RTsRJzNLsR0sK-bF95OBd_8qqfN1_fbL5dX7e3HD9eXF7etk0wvbe94P-gBFdcOhUKJVHrl5QhuHJApcDD2yPtOccvBU2AIAx98jxKs146fNtcrd0x2b-YcDnUvk2wwj4OUd8bmJbgJDRVInUanNRVi5KgrjGtaccoqIURlvVtZc07fjlgWs0_HHOv6hnVMS64YY0-qna3QEH16-IVDKM5cqB6glxR0VZ39Q1XPiIfgUkQf6vwvA1sNLqdSMvrfj6FgHoI3a_CmBm8egzf31cRXU6niuMP8tPF_XD8BgAmtlw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2729536222</pqid></control><display><type>article</type><title>Significance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinoma</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature OA Free Journals</source><creator>Missaoui, Nabiha ; Bdioui, Ahlem ; Baccouche, Atika ; Belkacem, Oussema ; Hmida, Wissem ; Mokni, Moncef ; Hmissa, Sihem</creator><creatorcontrib>Missaoui, Nabiha ; Bdioui, Ahlem ; Baccouche, Atika ; Belkacem, Oussema ; Hmida, Wissem ; Mokni, Moncef ; Hmissa, Sihem</creatorcontrib><description>Background
The study investigated the expression and the clinicopathological significance of p53, p27, Ki-67, E-cadherin, and HER2 in upper urinary tract urothelial carcinomas (UTUC) from Tunisian patients. We performed a retrospective study of 66 UTUC. Main clinicopathological features were reported. The expression of p53, p27, Ki-67, E-cadherin, and HER2 was investigated by immunohistochemistry on whole tissue section.
Results
Expression of p53, Ki-67, p27, E-cadherin, and HERE2 was reported in 36.4%, 69.7%, 90.9%, 100%, and 0% of cases, respectively. p53 expression was associated with stage (
p
= 0.001), positive surgical margin (
p
= 0.005), and shorter recurrence-free survival (RFS; Log Rank test,
p
= 0.026). Ki-67 and p27 expression was associated with stage (
p
< 0.001 and
p
= 0.001, respectively) and grade (
p
< 0.001 and
p
= 0.001, respectively). Using Kaplan-Meier test, the positive surgical margin was associated with shorter RFS compared to free surgical margin (Log Rank test,
p
= 0.031). Moreover, in univariate Cox regression analysis, surgical margin (
p
= 0.041; HR 0.325, 95% CI 0.110–0.956) and p53 expression (
p
= 0.035; HR 0.328, 95% CI 0.116–0.925) were the significant factors associated with RFS.
Conclusions
Together, our findings suggest that positive surgical margin and p53 expression were potential prognostic factors of UTUC since both were associated with shorter RFS in Tunisian patients.</description><identifier>ISSN: 2589-0409</identifier><identifier>ISSN: 1110-0362</identifier><identifier>EISSN: 2589-0409</identifier><identifier>DOI: 10.1186/s43046-020-00047-z</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Age ; Bladder cancer ; Cell cycle ; Cell growth ; Chemotherapy ; Cyclin-dependent kinases ; Gene amplification ; Kinases ; Lymphatic system ; Medical prognosis ; Medicine ; Medicine & Public Health ; Metastasis ; Oncology ; p53 expression ; Patients ; Positive surgical margin ; Proteins ; Survival ; Tumors ; Upper urinary tract urothelial carcinoma ; Urogenital system</subject><ispartof>Journal of Egyptian National Cancer Institute, 2020-09, Vol.32 (1), p.1-8, Article 36</ispartof><rights>The Author(s) 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-8c38b9be639ce46e5e15f6f5d0cdbe260c0d8e38763a30f102e0b3bf8e50af9c3</citedby><cites>FETCH-LOGICAL-c529t-8c38b9be639ce46e5e15f6f5d0cdbe260c0d8e38763a30f102e0b3bf8e50af9c3</cites><orcidid>0000-0001-6964-075X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>Missaoui, Nabiha</creatorcontrib><creatorcontrib>Bdioui, Ahlem</creatorcontrib><creatorcontrib>Baccouche, Atika</creatorcontrib><creatorcontrib>Belkacem, Oussema</creatorcontrib><creatorcontrib>Hmida, Wissem</creatorcontrib><creatorcontrib>Mokni, Moncef</creatorcontrib><creatorcontrib>Hmissa, Sihem</creatorcontrib><title>Significance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinoma</title><title>Journal of Egyptian National Cancer Institute</title><addtitle>J Egypt Natl Canc Inst</addtitle><description>Background
The study investigated the expression and the clinicopathological significance of p53, p27, Ki-67, E-cadherin, and HER2 in upper urinary tract urothelial carcinomas (UTUC) from Tunisian patients. We performed a retrospective study of 66 UTUC. Main clinicopathological features were reported. The expression of p53, p27, Ki-67, E-cadherin, and HER2 was investigated by immunohistochemistry on whole tissue section.
Results
Expression of p53, Ki-67, p27, E-cadherin, and HERE2 was reported in 36.4%, 69.7%, 90.9%, 100%, and 0% of cases, respectively. p53 expression was associated with stage (
p
= 0.001), positive surgical margin (
p
= 0.005), and shorter recurrence-free survival (RFS; Log Rank test,
p
= 0.026). Ki-67 and p27 expression was associated with stage (
p
< 0.001 and
p
= 0.001, respectively) and grade (
p
< 0.001 and
p
= 0.001, respectively). Using Kaplan-Meier test, the positive surgical margin was associated with shorter RFS compared to free surgical margin (Log Rank test,
p
= 0.031). Moreover, in univariate Cox regression analysis, surgical margin (
p
= 0.041; HR 0.325, 95% CI 0.110–0.956) and p53 expression (
p
= 0.035; HR 0.328, 95% CI 0.116–0.925) were the significant factors associated with RFS.
Conclusions
Together, our findings suggest that positive surgical margin and p53 expression were potential prognostic factors of UTUC since both were associated with shorter RFS in Tunisian patients.</description><subject>Age</subject><subject>Bladder cancer</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>Chemotherapy</subject><subject>Cyclin-dependent kinases</subject><subject>Gene amplification</subject><subject>Kinases</subject><subject>Lymphatic system</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastasis</subject><subject>Oncology</subject><subject>p53 expression</subject><subject>Patients</subject><subject>Positive surgical margin</subject><subject>Proteins</subject><subject>Survival</subject><subject>Tumors</subject><subject>Upper urinary tract urothelial carcinoma</subject><subject>Urogenital system</subject><issn>2589-0409</issn><issn>1110-0362</issn><issn>2589-0409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNp9kV1rFTEQhhdRsFb_gFcBb8-2k8_dXJZytKUFwY_rkM1OTnPYk6zJHtD-etOuWAWRXExmeN-HSd6meUvhjNJenRfBQagWGLQAILr2_llzwmSvWxCgn_9xf9m8KmUPoBR08qSZPoddDD44Gx2S5Mks-YbMrNuQm9CqWrats-Md5hA3xMaRXG0_MYLf54ylhBRJiOQ4z5jJsUps_kGWbN1Su7Tc4RTsRJzNLsR0sK-bF95OBd_8qqfN1_fbL5dX7e3HD9eXF7etk0wvbe94P-gBFdcOhUKJVHrl5QhuHJApcDD2yPtOccvBU2AIAx98jxKs146fNtcrd0x2b-YcDnUvk2wwj4OUd8bmJbgJDRVInUanNRVi5KgrjGtaccoqIURlvVtZc07fjlgWs0_HHOv6hnVMS64YY0-qna3QEH16-IVDKM5cqB6glxR0VZ39Q1XPiIfgUkQf6vwvA1sNLqdSMvrfj6FgHoI3a_CmBm8egzf31cRXU6niuMP8tPF_XD8BgAmtlw</recordid><startdate>20200915</startdate><enddate>20200915</enddate><creator>Missaoui, Nabiha</creator><creator>Bdioui, Ahlem</creator><creator>Baccouche, Atika</creator><creator>Belkacem, Oussema</creator><creator>Hmida, Wissem</creator><creator>Mokni, Moncef</creator><creator>Hmissa, Sihem</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6964-075X</orcidid></search><sort><creationdate>20200915</creationdate><title>Significance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinoma</title><author>Missaoui, Nabiha ; Bdioui, Ahlem ; Baccouche, Atika ; Belkacem, Oussema ; Hmida, Wissem ; Mokni, Moncef ; Hmissa, Sihem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-8c38b9be639ce46e5e15f6f5d0cdbe260c0d8e38763a30f102e0b3bf8e50af9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Bladder cancer</topic><topic>Cell cycle</topic><topic>Cell growth</topic><topic>Chemotherapy</topic><topic>Cyclin-dependent kinases</topic><topic>Gene amplification</topic><topic>Kinases</topic><topic>Lymphatic system</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastasis</topic><topic>Oncology</topic><topic>p53 expression</topic><topic>Patients</topic><topic>Positive surgical margin</topic><topic>Proteins</topic><topic>Survival</topic><topic>Tumors</topic><topic>Upper urinary tract urothelial carcinoma</topic><topic>Urogenital system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Missaoui, Nabiha</creatorcontrib><creatorcontrib>Bdioui, Ahlem</creatorcontrib><creatorcontrib>Baccouche, Atika</creatorcontrib><creatorcontrib>Belkacem, Oussema</creatorcontrib><creatorcontrib>Hmida, Wissem</creatorcontrib><creatorcontrib>Mokni, Moncef</creatorcontrib><creatorcontrib>Hmissa, Sihem</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of Egyptian National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Missaoui, Nabiha</au><au>Bdioui, Ahlem</au><au>Baccouche, Atika</au><au>Belkacem, Oussema</au><au>Hmida, Wissem</au><au>Mokni, Moncef</au><au>Hmissa, Sihem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinoma</atitle><jtitle>Journal of Egyptian National Cancer Institute</jtitle><stitle>J Egypt Natl Canc Inst</stitle><date>2020-09-15</date><risdate>2020</risdate><volume>32</volume><issue>1</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><artnum>36</artnum><issn>2589-0409</issn><issn>1110-0362</issn><eissn>2589-0409</eissn><abstract>Background
The study investigated the expression and the clinicopathological significance of p53, p27, Ki-67, E-cadherin, and HER2 in upper urinary tract urothelial carcinomas (UTUC) from Tunisian patients. We performed a retrospective study of 66 UTUC. Main clinicopathological features were reported. The expression of p53, p27, Ki-67, E-cadherin, and HER2 was investigated by immunohistochemistry on whole tissue section.
Results
Expression of p53, Ki-67, p27, E-cadherin, and HERE2 was reported in 36.4%, 69.7%, 90.9%, 100%, and 0% of cases, respectively. p53 expression was associated with stage (
p
= 0.001), positive surgical margin (
p
= 0.005), and shorter recurrence-free survival (RFS; Log Rank test,
p
= 0.026). Ki-67 and p27 expression was associated with stage (
p
< 0.001 and
p
= 0.001, respectively) and grade (
p
< 0.001 and
p
= 0.001, respectively). Using Kaplan-Meier test, the positive surgical margin was associated with shorter RFS compared to free surgical margin (Log Rank test,
p
= 0.031). Moreover, in univariate Cox regression analysis, surgical margin (
p
= 0.041; HR 0.325, 95% CI 0.110–0.956) and p53 expression (
p
= 0.035; HR 0.328, 95% CI 0.116–0.925) were the significant factors associated with RFS.
Conclusions
Together, our findings suggest that positive surgical margin and p53 expression were potential prognostic factors of UTUC since both were associated with shorter RFS in Tunisian patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43046-020-00047-z</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-6964-075X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature OA Free Journals |
| subjects | Age Bladder cancer Cell cycle Cell growth Chemotherapy Cyclin-dependent kinases Gene amplification Kinases Lymphatic system Medical prognosis Medicine Medicine & Public Health Metastasis Oncology p53 expression Patients Positive surgical margin Proteins Survival Tumors Upper urinary tract urothelial carcinoma Urogenital system |
| title | Significance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinoma |
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